ELECTRONIC POSTER - ismrm

White Matter Diseases
Hall B Monday 14:00-16:00 Computer 78
14:00 4342. Whole-Brain Histograms of the Bound Pool Fraction Reveal Delayed White and
Gray Matter Damage After Blast-Induced Mild Traumatic Brain Injury (MTBI)
Vasily L. Yarnykh 1 , Hunter R. Underhill 1 , Donna J. Cross 1 , K McCraw 2 , J Biberston 2 , D
J. Hoff 2 , K Hart 2 , Satoshi Minoshima 1 , Eric C. Petrie 3,4 , Murray A. Raskind 2 , Elaine R.
Peskind, 23
1 Department of Radiology, University of Washington, Seattle, WA, United States; 2 Northwest Network Mental
Illness Research, Education, and Clinical Center (MIRECC), Veterans Affairs Puget Sound Health Care
System, Seattle, WA, United States; 3 Department of Psychiatry & Behavioral Sciences, University of
Washington, Seattle, WA, United States; 4 Northwest Network Mental Illness Research, Education, and Clinical
Center (MIRECC) , Veterans Affairs Puget Sound Health Care System, Seattle, WA, United States
Cross-relaxation imaging (CRI) is a new method for quantitative mapping of parameters describing magnetization transfer between
mobile water protons (free pool) and macromolecular protons (bound pool) in tissues. The purpose of this study was to test the
capability of CRI to identify post-traumatic changes in brain tissues caused by blast-induced mTBI. CRI was performed in groups of
military veterans recently exposed to blast trauma and healthy controls. Bound pool fraction (f) maps were reconstructed using a novel
modification of the CRI processing algorithm. Histogram analysis revealed a significant decrease of f in both white and gray matter of
mTBI patients.
14:30 4343. DTI Parameters Predict Outcome in Severe Traumatic Brain Injury Patients
Joshua F. Betz 1 , Jiachen Zhuo 1 , Anindya Roy 2 , Kathirkamanthan Shanmuganathan 1 , Rao
P. Gullapalli 1
1 Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD,
United States; 2 Department of Mathematics and Statistics, University of Maryland Baltimore County,
Baltimore, MD, United States
Patients presenting with Diffuse Axonal Injury (DAI) follow a highly variable clinical course, with initial neurological status
frequently discrepant from long-term outcomes.
In this study, we compared Diffusion Tensor Imaging (DTI) parameters in 38 TBI patients with their Glasgow Coma Scale (GCS) at
discharge. The DTI parameters ADC and Axial Diffusion are shown to be correlated with the GCS at the time of MRI, and can be
used to predict survival better than GCS alone. In addition DTI parameters are able to predict neurological recovery at discharge.
15:00 4344. Diffuse Metabolic Abnormalities in Acute Mild Traumatic Brain Injury: A
Quantitative Proton MR Spectroscopy Study
Ivan Kirov 1 , James Babb 1 , Joseph Reaume 1 , Robert Grossman 1 , Oded Gonen 1
1 Radiology, New York University, New York, NY, United States
Since injury in mild traumatic brain injury is likely both minimal and diffuse, we used a proton MR spectroscopy (1H-MRS) strategy
of both high coverage and sensitivity. To achieve the former, a 3D 1H-MRS volume-of-interest (VOI) covered 360cc of mostly white
matter, and whole-brain 1H-MRS accounted for all the brain. For high sensitivity, all 480 spectra of the 3D VOI were summed,
yielding one spectrum per subject. Since B0 homogeneity is better across small voxels, spectra alignment before summation resulted
in excellent spectral resolution. Results revealed no neuronal dysfunction or atrophy, but diffuse elevation of choline and myo-inositol
in the 3D VOI.
15:30 4345. Parcellating Disconnectivity: Understanding the Microstructural Abnormalities
Associated with Neurocognitive Deficits in Traumatic Brain Injury
Virginia F. Newcombe 1,2 , Jo G. Outtrim 1 , Dot A. Chatfield 1 , Anne Manktelow 1 , Peter J.
Hutchinson 3 , Jon P. Coles 1,2 , Guy B. Williams 2 , Barbara Sahakian 4 , David K. Menon 1,2
1 Division of Anaesthesia, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom; 2 Wolfson
Brain Imaging Centre, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom; 3 Academic
Department of Neurosurgery, University of Cambridge, Cambridge, United Kingdom; 4 Department of
Psychiatry, University of Cambridge, Cambridge, United Kingdom
Impairment in decision making is commonly impaired post TBI contributing to the burden on healthcare systems worldwide.
Diffusion tensor imaging (DTI) in selected ROIs was correlated with neurocognitive performance in a decision making task, the
Cambridge Gambling Task; CGT. Cognitive performance on neuropsychological testing correlated significantly with diffusivity
parameters in cognate brain regions. Our data add to the evidence that loss of microstructural integrity, as detected by DTI, is an
important determinant of function following TBI, and confirm the involvement of key neurochemical networks in these complex
neurocognitive tasks. DTI may be a useful research and clinical tool in this setting.