ELECTRONIC POSTER - ismrm

14:00 4483. Deformable Registration and Tract-Based Spatial Analysis of Diffusion Tensor MR
Images in Mild Traumatic Brain Injury of Military-Related Blast Injury
Ping-Hong Yeh 1 , Binquan Wang, Terrence R. Oakes, 2 , Louis M. French 3 , David F.
Moore 3 , Gerard Riedy, 2,4
1 Henry Jackson Foundation for Military Medicine, Rockville, MD, United States; 2 National Capital
Neuroimaging Consortium, Walter Reed Army Medical Center, Washington DC; 3 Defense and Veterans Brain
Injury Center, Walter Reed Army Medical Center,; 4 Department of Radiology and Radiological Sciences,
Uniformed Services University
Evaluating the white matter disruption in mild traumatic brain injury (mTBI) is challenging. The study investigated mTBI in militaryrelated
blast injury using diffusion tensor imaging. High-dimensional spatial normalization of diffusion tensor images, atlas
reconstruction and tract-based spatial analysis were applied to assess the physiological and geometric changes in mTBI, and their
relationships with neuropsychopathic symptoms. The features of micro- and macro-structural changes varied within the mTBI group.
Greater severity of neuropsychopathic symptoms was associated with the disconnection in fronto-(sub)cortical, fronto-limbic and
inter-hemispheric circuitry. Optimizing spatial normalization method can help detect white matter disruption in mTBI using a low
field clinical scanner.
14:30 4484. Diffusional Kurtosis Imaging of Deep Gray Matter in Mild Traumatic Brain Injury
Elan J. Grossman 1 , Yulin Ge 1 , Jens H. Jensen 1 , James S. Babb 1 , Joseph Reaume 1 ,
Jonathan A. Silver 2 , Robert I. Grossman 1 , Matilde Inglese 1
1 Center for Biomedical Imaging, Department of Radiology, NYU School of Medicine, New York, United
States; 2 Department of Psychiatry, NYU School of Medicine, New York, United States
While conventional imaging has been unsuccessful detecting cerebral damage in mild traumatic brain injury (MTBI), investigations
using DTI report evidence of diffuse axonal injury. The purpose of the current study is to assess whether DKI, which measures non-
Gaussian diffusion of water, can provide additional complimentary information about MTBI pathology. In addition to white matter
regions we investigated thalamus and basal ganglia in patients with MTBI using DKI and DTI. Differences from controls were
observed in thalamus and posterior internal capsule of acute and chronic MTBI patients. This suggests that DKI and DTI might be
prognostic markers of persistent post-concussive syndrome.
15:00 4485. Combined Quantitative Diffusion Tensor and 1H Magnetic Resonance
Spectroscopic Imaging Findings in Patients with Persistent Neurocognitive Deficits Following
a Mild Traumatic Brain Injury.
Brenda Bartnik Olson 1 , Kimberly Conley 2 , Karen Tong 1 , Sarah Uffindell 3 , Valerie
Wong 4 , Barbara Holshouser 1
1 Dept. of Radiology, Loma Linda University, Loma Linda, CA, United States; 2 School of Medicine, Loma
Linda University, Loma Linda, CA, United States; 3 Dept. of Neurology, Loma Linda University, Loma Linda,
CA, United States; 4 Redlands Pediatric and Adult Medicine, Loma Linda University, Loma Linda, CA, United
States
Neurocognitive deficits occur in approximately 50-80% of mild TBI patients, which may persist for several years after injury even
though conventional imaging is normal. In this study we used diffusion tensor and 1H magnetic resonance spectroscopic imaging to
evaluate if microstructural and/or metabolic abnormalities are present in mTBI subjects with persistent neurocognitive deficits. Our
findings show that regions of neuronal loss or dysfunction are present in the left anterior internal capsule and left occipital white
matter of mild TBI patients. In addition, increased fractional anisotropy in the left anterior internal capsule may be related to an
increase in extracellular space adjacent to remaining axons after the loss of a subset of corticospinal tract fibers. Our findings suggest
that both metabolic and ultrastructural changes persist following a mild TBI which may relate to continued neurocognitive deficits
seen in these subjects.
Animal Models of Stroke & Ischemia
Hall B Monday 14:00-16:00 Computer 87
14:00 4486. Serial MR Analysis of Permanent and Transient Cerebral Ischemia in a Rat Model:
High and Low B Value Diffusion – Weighted Imaging and Diffusion Tensor Imaging
Ji-hoon Kim 1 , Kee-Hyun Chang, Chul Ho Sohn, Sung Hong Choi, Yoo Jung Yim, Chang
Min Park, In Chan Song
1 Radiology, Seoul National University Hospital, Seoul, Korea, Republic of
We tried to determine the serial changes in FA, ADC and DWI signal intensity at high and low b values during early cerebral ischemia
and transient ischemia and investigated their relationships. With 30 male Sprague-Dawley rats of middle cerebral artery occlusion
(MCAO) of the suture occlusion model, PWI, DTI, high and low b value DWI were performed for hyperacute (n=9) and acute (n=13)
permanent ischemia groups and transient (n=8) ischemia group. Although time-ADC curve showed early initial decrease until 3 hour
and then increasing tendency, Time – FA curve showed initial increase, transient plateau until 1 hour, and then sequential decrease in
permanent ischemia group. In transient ischemia group, FA showed transient reversibility and secondary decay in transient ischemia
group, correlating with ADC change. Although the lesion contrast ratio of DWI in early ischemic tissue was larger at high b value.
But, the lesion contrast ratio of ADC map was smaller at high b value than low b value. These results might be related to the initial
shift of water from extracellular to intracellular space and biexponential decay of cerebral water diffusion.