ELECTRONIC POSTER - ismrm

15:00 4641. Quantification of Hepatic Iron Overload: Usefulness of Echo-Planar Imaging Based
Diffusion-Weighted Magnetic Resonance Imaging
Tatsuyuki Tonan 1 , Kiminori Fujimoto 1 , Aliya Qayyum 2 , Takumi Kawaguchi 3 , Atsushi
Kawaguchi 4 , Koji Okuda 5 , Shuji Nagata 1 , Michio Sata 3 , Naofumi Hayabuchi 1
1 Radiology, Kurume University School of Medicine, Kurume, Fukuoka, Japan; 2 Radiology and Biomedical
Imaging, University of California San Francisco, San Francisco, CA, United States; 3 Internal Medicine, Kurume
University School of Medicine, Kurume, Fukuoka, Japan; 4 Biostatistics Center, Kurume University School of
Medicine, Kurume, Fukuoka, Japan; 5 Surgery, Kurume University School of Medicine, Kurume, Fukuoka,
Japan
MRI is sensitive to tissue iron overload because iron leads to a decline of magnetic resonance signal due to T2-shortening effect
related to the paramagnetic properties, and recently has become suitable technique for quantifying hepatic iron overload
noninvasively. The aim of this study is to assess the usefulness of echo-planar image based diffusion- weighted image (EPI-DWI) for
quantifying subtle hepatic iron stores. We found a good correlation between EPI-DWI and hepatic iron concentration in patients with
viral hepatitis, and demonstrated that EPI-DWI was more sensitive sequence for quantifying hepatic iron overload than gradientrecalled
echo sequence.
Thursday 13:30-15:30 Computer 96
13:30 4642. Multislice Multiecho T2* MRI for Detection of the Distribution of Hepatic Iron
Overload.
Antonella Meloni 1 , Antongiulio Luciani 2 , Alessia Pepe 1 , Vincenzo Positano 1 , Gennaro
Restaino 3 , Maria Chiara Dell'Amico 1 , Brunella Favilli 1 , Gianna Alberini 1 , Giovanni
Palazzi 4 , Massimo Lombardi 1
1 MRI Lab, “G. Monasterio Foundation” and Institute of Clinical Physiology, CNR, Pisa, Italy; 2 Istituto di
Radiologia Az. Osp. "Garibaldi", Catania, Italy; 3 Catholic University, Campobasso, Italy; 4 Policlinico di
Modena, Modena, Italy
The goals of our study were to set up a MRI acquisition technique for the detection of the iron burden in the whole liver of thalassemia
major patients. Significant differences in the segmental T2* values were found. Specifically, the mean T2* values over the segments
VI and VIII were significantly lower than the mean T2* values over the other segments. However, T2* variations in liver are low and
likely due to the artefacts effects and measurement variability.
14:00 4643. Hepatic Lipid Quantification with MRS: BMI, T2, and Prandial Correlations.
Robert D. O'Connor 1 , Gary Skolnick 2 , Nicole Nejedly 2 , Adil Bashir 1 , Samuel Klein 2
1 Radiology, Washington University, St. Louis, MO, United States; 2 Geriatrics and Nutritional Science,
Washington University School of Medicine, St. Louis, MO, United States
MRS protocols for hepatic lipid quantification are examined. It is concluded that an optimal protocol can achieve a CV of at least 5%.
14:30 4644. Three-Dimensional Two-Point Dixon Acquisition with Projections Onto Convex Sets
(POCS) for Abdominal Imaging
Agus Priatna 1 , Vamsi Narra 2
1 MR R&D Collaborations, Siemens Healthcare, St Louis, MO, United States; 2 Mallinckrodt Institute of
Radiology, Washington University, St Louis, MO, United States
Three-dimensional two-point Dixon technique has been routinely used for liver imaging to provide opposed and inphase images, as
well as fat only and water only images. Phase partial Fourier and strong echo asymmetry are often employed to reduce the scan time.
However, echo asymmetry and phase partial Fourier with zero filling result in blurring artifacts in the in-plane view. This abstract
describes the use of phase correction with projection onto convex sets (POCS) to the three dimensional two-point Dixon sequence in
order to reduce blurring artifact and improve image quality at short scan times
15:00 4645. Contribution of Phase-Contrast Magnetic Resonance Imaging in the Study of
Hepatic Fibrosis: Preliminary Results
Thierry Yzet 1 , Roger Bouzerar 2 , Eric Nguyen-Khac 3 , Brice Robert 1 , Denis Chatelain 4 ,
Hervé Deramond 1 , Marc-Etienne Meyer 2 , Olivier Baledent 2
1 Radiology, University Hospital, Amiens, France; 2 Imaging and Biophysics, University Hospital, Amiens,
France; 3 Hepato-Gastroenterology, University Hospital, Amiens, France; 4 Pathological Cytology, University
Hospital, Amiens, France
Hepatic fibrosis is secondary to many etiologies and quantification of this fibrosis is a key point for the clinician. In this work, we
wanted to appraise the potential links between elastometry data and parameters measured using PC-MRI in 17 subjects developing
hepatic pathologies. Three distinct groups, probably representative of the stage of hepatic fibrosis, clearly appear A statistically
significant linear correlation between the elasticity modulus and the vessel area variations DS or the portal congestion index IC is
clearly highlighted. PC-MRI could be a useful and complementary tool for the understanding of evolution mechanisms involved in
hepatic fibrosis.