ELECTRONIC POSTER - ismrm

Thursday 13:30-15:30 Computer 75
13:30 4306. Quantitative MRI Analysis of Aging of Human Fat Tissue: Intra-Orbital Versus
Extra-Orbital Fat
Memi Watanabe 1 , Osamu Sakai 1 , Joseph Liao 1 , Hernan Jara 1,2
1 Department of Radiology, Boston Medical Center, Boston University School of Medicine, Boston, MA, United
States; 2 Department of Biomedical Engineering, Boston University, Boston, MA, United States
Purpose: To study the aging pattern of intra- vs. extra-orbital fat tissue, using multispectral quantitative MR imaging (qMRI).
Methods: Forty-two subjects (M:F=21:21, age: 0.5-87 years, average 31.5) were examined with experimental mixed turbo spin echo
(mixed-TSE) sequence. Region-of-interest (ROI) measurements of retrobulbar fat, buccal fat and subcutaneous fat tissues were
obtained for multispectral qMRI analysis. Results: PD and T1 values of all fat tissues showed similar tissue characteristics and aging
patterns, while a decrease in T1 and secular-T2 values was seen in extra-orbital fat with aging. Conclusion: Multispectral qMRI data
of aging in intra- and extra-orbital fat tissues were obtained.
14:00 4307. High-Resolution Diffusion-Weighted Imaging of the Orbits Using Readout-
Segmented EPI
Roland Bammer 1 , Kristen W. Yeom 1 , Samantha J. Holdsworth 1 , Stefan T. Skare 1
1 Radiology, Stanford University, Stanford, CA, United States
Diffusion-weighted MRI (DWI) of the Orbits bears great diagnostic potential. Its use, however, has been limited due to profound
geometric distortions and signal loss related to single-shot EPI. We demonstrate that diffusion-weighted readout-segmented (RS)-EPI
with its significant distortion reduction capacity can provide high-resolution DWI and DTI scans that allows one to delineate intraorbital
structures within clinically reasonable scan times. A consecutive series of 35 pediatric patients was enrolled in a comparative
evaluation and a 100% superiority of RS-EPI (both in resolution and distortion reduction) over ASSET-enhanced EPI could be
demonstrated.
14:30 4308. The Effects of Age, Gender and BMI on Parotid Fat and Parotid ADC
Measurements in EPI Based and FSE-PROPELLER Based Diffusion Weighted Imaging
Hui-Chu Chiu 1,2 , Chun-Jung Juan 3 , Hing-Chiu Chang 4,5 , Hsiao-Wen Chung 3,5 , Cheng-
Chieh Cheng 3,5 , Su-Chin Chiu 3,5 , Cheng-Yi Cheng 1 , Cheng-Yu Chen 3 , Guo-Shu Huang 3
1 Department of Nuclear Medicine, Tri-Service General Hospital, Taipei, Taiwan; 2 EMBA in Global Chinese
Management, Department of Business Administration, College of Management, Tamkang University, Taipei,
Taiwan; 3 Department of Radiology, Tri-Service General Hospital, Taipei, Taiwan; 4 Applied Science
Laboratory, GE Healthcare Taiwan, Taipei, Taiwan; 5 Institute of Biomedical Electronics and Bioinformatics,
National Taiwan University, Taipei, Taiwan
The effects of age, gender and body mass index (BMI) on parotid fat content and parotid ADC measurements have never been
investigated yet. In this study, we measured parotid ADC values using non-fat-saturated and fat-saturated DWI pulse sequences
including fast spin-echo PROPELLER and echoplanar acquisitions. Our results highlight the parotid fat content is influenced by
gender and is significantly positively associated with age and BMI. The parotid fat content has a significantly negative effect on
parotid ADC values that is most apparent in non-fat-saturated DWI pulse sequence and the effect could not be remedied by any fatsaturated
DWI pulse sequence.
15:00 4309. Cortical Activation During Swallowing Rehabilitation Maneuvers: A Functional
MRI Study of Healthy Controls
Kyung K. Peck 1 , Ryan Branski, Cathy Lazarus 2 , Victoria Cody, Devon Kraus, Samantha
Haupage, Cindy Ganz, Andrei Holodny, Dennis Kraus
1 Medical Physics and Radiology, Memorial Sloan-Kettering Cancer Center, New York, United States; 2 New
York University
Both the Effortful and Mendelsohn maneuver are currently used in the clinical setting as a component of a comprehensive
rehabilitation of swallowing. However, the brain responses to these tasks and how activation differs from dry swallowing has not been
investigated. In this study, we seek to provide preliminary data regarding the neural networks associated with commonly-employed
rehabilitation strategies. We hypothesize that with increased understanding of the neural bases behind these maneuvers, factors of
peripheral injury as well as the central adaptor response can be considered in order to develop enhanced rehabilitation strategies for
this challenging patient population