ELECTRONIC POSTER - ismrm

measurement of the tissue-blood partition coefficient using a three compartment model yields similar values between infarcted and
viable myocardium. T1 relaxation differences are likely due to a third trapping compartment.
Molecular Imaging in Cardiovascular Disease & Cancer
Hall B Monday 14:00-16:00 Computer 40
14:00 3741. A DNA-Targeted Gadolinium Chelate to Selectively Enhance Acutely Injured
Myocardium
Shuning Huang 1 , Hushan Yuan 2 , Howard Chen 3 , Guangping Dai 1 , Lee Josephson 2 , David
E. Sosnovik 1,3
1 Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States;
2 Center for Translation Nuclear and Molecular Imaging, Massachusetts General Hospital, Charlestown, MA,
United States; 3 Center for Molecular Imaging Research, Massachusetts General Hospital, Charlestown, MA,
United States
Delayed enhancement of gadolinium cannot discriminate acute and chronic injury since both produce similar changes in the
pharmacokinetics of small gadolinium chelates, such as Gd-DTPA. Here, we demonstrated that the acute myocardial infarction can be
distinguished from both subacute and chronic myocardial injury by utilizing a DNA-targeted gadolinium chelate (Gd-TO).
14:30 3742. 21 Tesla Rat Heart Magnetic Resonance Microimaging by Paramagnetic Anti-
Troponin Bound Polyethylene Based Iron-Oxide Nanoparticles and Image Processing
Rakesh Sharma 1,2 , Kiran Shetty, 3
1 FAMU-FSU College of Engineering,, CIMAR, National High Magnetic Field Laboratory, Tallahassee, FL,
United States; 2 Center of Nanomagnetics and Biotechnology, Florida State University & TCC, Tallahassee, FL,
United States; 3 NHMFL, Florida State University, Tallahassee, FL, United States
The 21T MR microimaging by using first time troponin nanoparticles enhances the visualization of cardiac muscles fiber and offers
technical advancement in future. Diffusion weighting offers the fiber tracking and functional analysis. Image processing offers heart
probabilistic atlas and maps.
15:00 3743. Optimization of Ultrashort TE Imaging for Angiography and Molecular Imaging of
Iron-Oxide Nanoparticles
Ravi Teja Seethamraju 1 , Sonia Nielles-Vallespin 2 , Shuning Huang 3 , David E. Sosnovik 3,4
1 MR R and D, Siemens Medical Solutions, USA Inc., Charlestown, MA, United States; 2 Cardiovascular MR,
Royal Brompton Hospital, London, United Kingdom; 3 Radiology, Martinos Center for Biomedical Imaging,
Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States; 4 Center for
Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United
States
Iron oxide based USPIOs inherently exhibit T1 shortening apart from their traditional T2 properties. This property is best utilized at
ultrashort echo times. We demonstrate how a single UTE sequence can produce both angiographic images as well as molecular
quantitation.
15:30 3744. PEGylated Nano-Peaches: A Novel Multimodality Platform for Imaging of
Atherosclerosis
Andrei Maiseyeu 1 , Georgeta Mihai 1 , Marcus A. Badgeley 1 , Orlando P. Simonetti 1 , Jeffrey
A. Deiuliis 1 , Chandan K. Sen 1 , Sampath Parthasarathy 1 , Sanjay Rajagopalan 1
1 Heart and Lung Research Institute, The Ohio State University, Columbus, OH, United States
Novel "peach-like" nanoparticle (NP) contrast agents were manufactured, characterized and tested. In-vitro studies showed
preferential uptake of NPs by macrophages while in-vivo studies in ApoE-deficient mice revealed protracted signal enhancement of
atherosclerotic plaque. Proper design and ease of fabrication of these nanostructures makes them very versatile as either T1 or T2 MRI
contrast agents. These NPs loaded with fluorescein or near-infrared emitting quantum dots represent attractive tools for multimodality
imaging of atherosclerosis.
Tuesday 13:30-15:30 Computer 40
13:30 3745. 3.0T MRI of Auto-Transplantation of Bone Marrow-Derived Stem-Progenitor
Cells: Toward Cell-Based Repair of Injured Arteries
Yanfeng Meng 1,2 , Feng Zhang 1 , Tiffany Blair 1 , Huidong Gu 1 , Hongqing Feng 1 , Jinnan
Wang 3 , Chun Yuan 1 , Zhaoqi Zhang 2 , Bensheng Qiu 1 , Xiaoming Yang 1
1 Radiology, University of Washington, Seattle, WA, United States; 2 Radiology, Beijing Anzhen Hospital,
Beijing, China; 3 Clinical Sites Research Program, Philips Research North America, Briarcliff Manor, NY,
United States
This study was to validate the feasibility of using clinical 3.0T MRI to monitor the migration of auto-transplanted bone marrow cells
(BMC) to the injured arteries of near-human-sized animals. BMCs were extracted endogenously, labeled with Feridex and/or PKH26,