ELECTRONIC POSTER - ismrm

15:00 4325. Abnormal Iron Content in Deep Grey Matter Structures of MS Patients as a
Function of Age
Charbel Abdo Habib 1 , James Garbern, 1,2 , Manju Liu 1 , Ewart Mark Haacke 1
1 Radiology, Wayne State University, Detroit, MI, United States; 2 Neurology, Wayne State University, Detroit,
MI, United States
Multiple sclerosis (MS) is a disease whose etiology until recently has remained a mystery. A possible explanation for MS has been put
forward by Zamboni et al that it is caused by a chronic cerebrospinal venous insufficiency (CCSVI). In this abstract, we show that the
iron deposition seen by susceptibility weighted imaging (SWI) in MS patients is abnormal compared to normal controls and appears in
areas drained by the medial venous drainage system. This finding is consistent with the CCSVI hypothesis.
Multiple Sclerosis II
Hall B Monday 14:00-16:00 Computer 77
14:00 4326. Deep Gray Matter Atrophy in a Large Sample of Clinically Isolated Syndrome and
Early Relapsing-Remitting Multiple Sclerosis Patients
Niels Bergsland 1 , Michael G. Dwyer 1 , Dana Horakova 2 , Ondrej Dolezal 1 , Zdenek Seidl 3 ,
Manuela Vaneckova 3 , Eva Havrdova 2 , Robert Zivadinov 4
1 University at Buffalo, Buffalo Neuroimaging Analysis Center, Buffalo, NY, United States; 2 Charles
University, Department of Neurology, Prague, Czech Republic; 3 Charles University, Department of Radiology,
Prague, Czech Republic; 4 Neurology, Buffalo Neuroimaging Analysis Center, Buffalo , NY , United States
To quantify deep gray matter (DGM) atrophy in a large sample of clinically isolated syndrome (CIS) patients, early relapsingremitting
(RR) multiple sclerosis (MS) patients, and healthy controls (HC). To investigate the relationship between DGM atrophy and
disability in CIS patients.
14:30 4327. Exploring the Relations Between Emotional Disability and Subcortical Atrophy in
Patients with Multiple Sclerosis
Francesca Bagnato 1 , Clelia Pellicano 1 , Fredric Cantor 1 , Antonio Gallo 1 , Sungyoung
Auh 2 , Mary Ehrmantraut 1 , Iordanis Evangelou 1 , Vasiliki Ikonomidou 1 , Robert Kane 3 ,
Joan Ohayon 1 , Susan Stern 1 , Henry McFarland 1
1 NIB-NINDS-NIH, Bethesda, MD, United States; 2 Clinical Director Office-NINDS-NIH, Bethesda, MD,
United States; 3 VA, Baltimore
Pathophysiological mechanisms underlying the development of depression in patients with multiple sclerosis (MS) remain unknown.
We here demonstrate that atrophy of deep grey matter (GM) structures of the limbic circuit, such as thalamus and hippocampus, may
explain up to 30% of the variance of depression in MS. The relation between depression and GM atrophy holds significant when the
effect of patients’ physical disability is taken into account. The results highlight the role of neurodegeneration in specific brain sites as
an important factor associated with depression in MS patients.
15:00 4328. A Five-Year Serial Longitudinal Study of Deep Gray Matter Atrophy in Patients
with Multiple Sclerosis
Robert Zivadinov 1 , Dana Horakova 2 , Michael G. Dwyer 3 , Deepa Ramasamy 3 , Eva
Havrdova 2 , Zdenek Seidl 4 , Ondrej Dolezal 3 , Sara Hussein 3 , Ellen Carl 3 , Manuela
Vaneckova 4 , Niels Bergsland 3
1 Neurology, Buffalo Neuroimaging Analysis Center, Buffalo , NY , United States; 2 Charles University,
Department of Neurology, Prague, Czech Republic; 3 University at Buffalo, Buffalo Neuroimaging Analysis
Center, Buffalo, NY, United States; 4 Charles University, Department of Radiology, Prague, Czech Republic
To compare the evolution of deep gray matter (DGM) atrophy in early relapsing-remitting (RR) multiple sclerosis (MS) patients and
in normal controls (NC) over 2 years. To investigate the extent of DGM atrophy progression in MS patients over 5 years.
15:30 4329. Relation Between Thalamic Atrophy and Long-Term Disability Progression in
Multiple Sclerosis: A 8-Year Follow Up Study
Maria A. Rocca 1 , Sarlota Mesaros 1 , Elisabetta Pagani 1 , Maria Pia Sormani 1,2 , Vittorio
Martinelli 3 , Giancarlo Comi 3 , Massimo Filippi 1
1 Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific
Institute and University Hospital San Raffaele, Milan, Italy; 2 Unit of Biostatistics, DISSAL, University of
Genoa, Genoa, Italy; 3 Department of Neurology, Scientific Institute and University Hospital San Raffaele,
Milan, Italy
We assessed the value of thalamic damage (in terms of atrophy and magnetization transfer ratio-MTR), taken in isolation, and its
short-term changes in predicting accumulation of disability over an 8-year period in 73 patients with relapse-onset multiple sclerosis
(MS). At the end of follow up, 44 patients (60%) showed a significant disability worsening. A multivariable model included baseline
thalamic fraction [p=0.01, odds ratio (OR)=0.62], and average lesion MTR percentage change after 12 months (p=0.04, OR=0.90) as