ELECTRONIC POSTER - ismrm

Myocardial Function Human & Experimental Studies
Hall B Monday 14:00-16:00 Computer 28
14:00 3552. Free Breathing Navigator Gated Cine Cardiac MR at 3T: Feasibility Study in
Patients.
Chika Obele 1 , Christopher Sibley 2 , Jatin Matta 1 , Roderic I. Pettigrew 1 , Ahmed M.
Gharib 1
1 Integrative Cardiovascular Imaging Section, The National Institute of Diabetes and Digestive and Kidney
Diseases, National Institutes of Health, Bethesda, MD, United States; 2 Radiology and Imaging Sciences
Department, National Institutes of Health.
We demonstrate the feasibility of obtaining free-breathing cine images utilizing a single respiratory navigator gating technique. This
method was made possible by utilizing the high signal-to-noise ratio (SNR) available at 3T to apply parallel imaging methods
allowing the acquisition of up to 30 cardiac phases within clinically acceptable imaging time. Compared to traditional breath-holding
techniques this methods showed no statistical difference in qualitative and quantitative imaging parameters, thereby, could be used as
an alternative for children and patients who are unable to hold their breath.
14:30 3553. Pericardial Fat Overlaying the Left Ventricle: A Better Indicator of Left
Ventricular Function
Ning Hua 1 , Zhongjing Chen 1 , Sherman Bigornia 1 , Alkystis Phinikaridou 1 , Ye Qiao 1 ,
Caroline Apovian 1 , Hernan Jara 1 , Frederick Ruberg 1 , James Hamilton 1
1 Boston University, Boston, MA, United States
We imaged 40 metabolic syndrome (MetS) subjects as well as 17 healthy controls using MRI to determine if left ventricular (LV)
function would be better correlated with LV fat instead of total pericardial fat. We found that in MetS subjects, stroke volume, cardiac
output(CO), wall mass, end-diastolic volume and early filling (E) rate were inversely related to LV fat but not RV fat. The total
pericardial fat was only correlated with CO and E-rate. This study suggests that LV pericardial fat rather than total pericardial fat
might better correlate to LV function, the mechanism of which remains to be defined.
15:00 3554. Real-Time 3D Visualization of the Heart
Joseph Yitan Cheng 1 , Juan M. Santos 1,2 , John M. Pauly 1
1 Electrical Engineering, Stanford University, Stanford, CA, United States; 2 HeartVista, Inc., Los Altos, CA,
United States
The lack of proper visual guidance greatly impairs and lengthens cardiac procedures, such as atrial fibrillation therapy. In this work,
we present a practical approach for fast data acquisition and 3D visualization. Acquisition is achieved with a fast multi-slice spiral
sequence, and the visualization is achieved with a simple tissue segmentation and surface rendering. With the introduced depth
perception, we provide real-time visual feedback for better control in interventional cardiac treatment.
15:30 3555. Assessment of Cardiac Remodelling After Myocardial Infarction in Diabetic Mice
Using Self-Gated MRI
Kristine Skårdal 1 , Natale Rolim 1 , Ole Christian Eidheim 2 , Marius Widerøe 1 , Ulrik
Wisløff 1 , Pål Erik Goa 3 , Marte Thuen 1
1 Department of Circulation and Medical Imaging, Norwegian University of Science and Technology,
Trondheim, Norway; 2 Department of Laboratory Medicine, Children's and Women's Health, Norwegian
University of Science and Technology, Trondheim, Norway; 3 Department of Medical Imaging, St. Olavs
University Hospital, Trondheim, Norway
Type II diabetic patients suffer from higher susceptibility to develop post myocardial infarction (MI) heart failure. By adapting a selfgated
FLASH to a murine model of the diabetic heart, we obtained multiple slices of the left ventricle and assessed changes in cardiac
physiology post MI. Diabetic MI mice displayed decreased cardiac contractility and increased end-systolic volume, while non-diabetic
MI mice presented increased end-diastolic volume with preserved ejection fraction. These data suggest that imaging of murine hearts
is achievable using a self-gated FLASH, and the results are accurate enough to detect differences in functional analysis between
genotypes and interventions.
Tuesday 13:30-15:30 Computer 28
13:30 3556. Radial Tagging for Assessment of Circumferential Myocardial Function
Melanie S. Kotys 1 , Xiaopeng Zhou 2 , Scott D. Flamm 2 , Randy M. Setser 2
1 MR Clinical Science, Philips Healthcare, Cleveland, OH, United States; 2 Imaging Institute, Cleveland Clinic,
Cleveland, OH, United States
Myocardial tags applied in radial orientation using selective saturation bands may have distinct advantages over SPAMM methods for
routine clinical examinations. We compared radial tagged images with 4-16 tag lines and grid tagged images in five volunteers.
Analysis revealed that radial tags persisted longer than grid tags and had a comparable first acquired cardiac phase. There was no
significant difference in end systolic strain or rotation and 12 radial tag lines had the least variation in both measures. Application of
radial tags appears to be as efficient as SPAMM tagging with the potential for clinical analysis of circumferential myocardial function.