ELECTRONIC POSTER - ismrm

15:30 4505. Manganese-Enhanced MRI Detection of Neural Compensatory Changes After
Neonatal Monocular Enucleation
Iris Y. Zhou 1,2 , April M. Chow 1,2 , Shu Juan Fan 1,2 , Ed X. Wu 1,2
1 Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Pokfulam, Hong
Kong SAR, China; 2 Department of Electrical and Electronic Engineering, The University of Hong Kong,
Pokfulam, Hong Kong SAR, China
In this study, in vivo MEMRI was introduced to investigate cellular alteration and manganese-induced signal intensity changes after
neonatal monocular enucleation. With MEMRI, impaired superior colliculi with high spatial resolution revealing the laminar structure
and enhancement of monocular area of primary visual cortex can be observed after neonatal monocular enucleation noninvasively.
Such MEMRI approach may be useful in investigation of neural plasticity and the adaptive and compensatory modifications within the
brain following neonatal monocular enucleation.
Tuesday 13:30-15:30 Computer 88
13:30 4506. Manganese-Enhanced MRI of Perilesion Cortex in Subchronic Focal Brain
Ischemia
Kevin C. Chan 1,2 , Ed X. Wu 1,2
1 Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR,
China; 2 Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR,
China
In this study, MEMRI was employed to investigate into the late changes in Mn2+ enhancement in subchronic focal brain ischemia,
with emphases on the temporal evolutions in different subregions of the perilesion cortex. The results of this study may provide a new
tool for in vivo longitudinal monitoring of the of salvageable tissues and hence represent potential new therapeutic targets for
improving the functional consequences after stroke.
14:00 4507. Bimodal FMRI for Exploring Brain Activity: A Striatal CBV Response
Accompanied by Enhanced Nigrostriatal Activity Detected by MEMRI
Chiao-Chi V. Chen 1 , Yi-Hua Hsu 2 , Chen Chang 2
1 Functional and Micro-Magnetic Resonance Imaging Center,, Institute of Biomedical Sciences, Academia
Sinica, Taipei, Taiwan; 2 Functional and Micro-Magnetic Resonance Imaging Center, Institute of Biomedical
Sciences, Academia Sinica, Taipei, Taiwan
Brain activation can be evaluated by a bimodal fMRI protocol that utilizes hemodynamics based fMRI and manganese-enhanced MRI
(MEMRI) in combination. The present study demonstrates a striatal CBV response accompanied by enhanced nigrostriatal activity
detected by MEMRI following peripheral electrical stimulation.
14:30 4508. Regional Difference in Mn Uptake and Retention in Mouse Brain
Abu-Bakar-Md-Ali Asad 1 , Kai-Hsiang Chuang 1
1 Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Agency for Science, Technology and
Research, Singapore, Singapore
We compared the difference in Mn uptake and retention rates at various brain regions after systemic administration of MnCl2. By
estimating Mn concentration with the change in T1 relaxation rate (ΔR1), it was observed that different brain regions have
considerable difference in the time-to-peak and bioelimination rate of Mn. The ΔR1-time course was fitted to a gamma variate model
which showed reasonable fit and provides estimation of time-to-peak, peak value and half-life. The olfactory bulb reached the peak
earliest and highest, while regions like thalamus reached peak at day 2. Olfactory bulb had fastest clearance with a half-life of 6.6
days, and cerebellum had longer half-life of 11.5 days. This method can allow better estimate of the uptake and retention and can be
used to maximize tissue contrasts or applied to studying of transporter mechanism in animal models.
15:00 4509. Detection of Brain Activity During Chronic Pain Using Activity-Induced
Manganese-Enhanced MRI in the Ra
Yuko Kawai 1 , Masahiro Umeda 1 , Yasuharu Watanabe 1 , Toshihiro Higuchi 2 , Shoji
Naruse 3 , Chuzo Tanaka 2
1 Medical Informatics, Meiji University of Integrative Medicine, Kyoto, Japan; 2 Neurosurgery, Meiji University
of Integrative Medicine, Kyoto, Japan; 3 Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan
IntroductionzNerve injury occasionally induces neuropathic pain, which is a type of chronic pain. The cardinal symptom of
neuropathic pain is spontaneous or touch-evoked pain. The purpose of this study is to detect brain activation during foot stimulation
by using Activity-induced manganese-enhanced (AIM) MRI in a segmental spinal nerve ligation (SNL) model. Methods The right
L5–L6 spinal nerves were ligated with 5–0 silk sutures. AIM MRI were acquired using a 4.7-T MRI system. ResultsPain-induced
brain activation was successfully visualized using AIM MRI. It suggested that the AIM MRI is useful for the depiction of the
conducting pathway of pain.