ELECTRONIC POSTER - ismrm

15:00 4249. Are Behavioural Symptoms of Alzheimer’S Disease Directly Associated to
Neurodegeneration?
Laura Serra 1 , Roberta Perri 2 , Mara Cercignani 1 , Barbara Spanò 1,3 , Lucia Fadda 2,4 ,
Camillo Marra 5 , Giovanni Augusto Carlesimo 2,4 , Carlo Caltagirone 2,4 , Marco Bozzali 1
1 Neuroimaging laboratory, Fondazione IRCCS Santa Lucia, Roma, Italy; 2 Department of Clinical and
Behavioural Neurology, Fondazione IRCCS Santa Lucia, Roma, Italy; 3 Direzione Scientifica, , IRCCS Centro
Neurolesi ‘Bonino-Pulejo’, Messina, Italy; 4 Department of Neuroscience, University of Rome ‘Tor Vergata’,
Roma, Italy; 5 Institute of Neurology, Università Cattolica, Roma, Italy
Psychiatric symptoms (BPSD) are frequently observed in the clinical course of Alzheimer’s disease (AD). We used voxel-based
morphometry to identify, in a large cohort patients with AD at different clinical stages, which BPSD are more significantly associated
with regional gray matter degeneration. Correlation analyses showed an association between disinhibition and GM volumes in the
cingulate gyrus bilaterally, and in the right middle frontal gyrus, and between delusions and GM volume of the right hippocampus
and parahippocampal gyrus, and of the right middle frontal gyrus. These findings indicate that BPSD are likely part of the clinical
features of AD.
Wednesday 13:30-15:30 Computer 72
13:30 4250. Retrospective Distortion Correction Using the ADNI Phantom to Salvage Unusable
Exams
Bogdan Dzyubak 1 , Jeffrey L. Gunter 1 , Edward Brian Welch 2 , Ron J. Killiany 3 , Clifford R.
Jack 1 , Matt A. Bernstein 1
1 Radiology, Mayo Clinic, Rochester, MN, United States; 2 Philips Healthcare, Highland Heights, OH, United
States; 3 Boston University School of Medicine, Boston, MA, United States
During the Alzheimer’s Disease Neuroimaging Initiative (ADNI) multicenter study, a laser alignment light was mis-calibrated on one
scanner, leading to a displacement error in the isocenter location used during image reconstruction. Consequently, the standard
gradient distortion correction was inaccurate and the resulting data were unusable for longitudinally tracking brain changes. Off-line
processing was used to remove the aberrant distortion correction from ADNI phantom data, then those images were shifted by a
variable displacement, and finally the images were re-corrected for gradient distortion. The actual displacement error was determined
by this method and the subject data could be re-corrected and salvaged.
14:00 4251. Findings of Nonlinear Behaviors of Log-Signal Intensities on DTI in Patients with
Alzheimer¡¯s Disease
Geon-Ho Jahng 1 , Songfan Xu 2 , Chang-Woo Ryu 1 , Dal-Mo Yang 1 , Dong-Wook Sung 3 ,
Dong Ho Lee 3 , Seungjoon Park 4
1 Radiology, East West Neo Medical Center, Kyung Hee University, Seoul, Korea, Republic of; 2 Biomedical
Science, Graduate School of Medicine, Kyung Hee University, Seoul, Korea, Republic of; 3 Radiology, KHU
Hospital, Kyung Hee University, Seoul, Korea, Republic of; 4 Pharmacology and and Biomedical Science,
School of Medicine, Kyung Hee University, Seoul, Korea, Republic of
Proposing Calculation of Voxel-based B-values on DTI in Patients with Alzheimer’s Disease
14:30 4252. Early and Late Onset Alzheimer’s Disease Patients Have Distinct Patterns of White
Matter Damage
Elisa Canu 1 , Federica Agosta 1 , Michela Pievani 1,2 , Giovanni B. Frisoni 3 , Massimo
Filippi 1
1 Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific
Institute and University Hospital San Raffaele, Milan, Italy; 2 LENITEM, IRCCS S.Giovanni di Dio,
Fatebenefratelli, Brescia, Italy; 3 LENITEM, IRCCS Centro San Giovanni di Dio - FatebenefratelliIRCCS
Centro San Giovanni di Dio, Fatebenefratell, Brescia, Italy
SPM5 and the DARTEL method were used to perform a VBM analysis to assess WM differences in 14 early onset AD (EOAD) and
15 late onset AD (LOAD) vs. age- and gender-matched healthy controls (HC). Compared to HC, in EOAD patients, WM loss was
mapped mainly to the posterior regions such as the posterior cingulum and the lateral parietal regions, bilaterally. In LOAD patients,
WM loss was confined to the medial temporal lobe in the parahippocampal regions. Our findings indicate that EOAD and LOAD
patients differ in the topography of WM damage, which reflects the pattern of cortical loss.
15:00 4253. The Diffusivity Pattern of White Matter Degeneration in Semantic Dementia Is
Spatially and Qualitatively Different from Alzheimer's Disease
Julio Acosta-Cabronero 1 , George Pengas 2 , Guy B. Williams 1 , Peter J. Nestor 2
1 Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge,
Cambridgeshire, United Kingdom; 2 Neurology Unit, Department of Clinical Neurosciences, University of
Cambridge, Cambridge, Cambridgeshire, United Kingdom
The diffusion profile in semantic dementia (SD) was studied to examine the profile of connection changes. Tract-based spatial
statistics in SD patients provided compelling evidence that the network is distinct to that of Alzheimer’s disease (AD), and indicated
that the key abnormality exiting the temporal lobe was in the uncinate fasciculus projection to the orbital frontal lobe. The tensor
behaviours also indicated that the nature of the neurodegenerative in SD differs qualitatively from that seen in AD.