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15:00 4799. Phosphocholine/Glycero-Phosphocholine Ratio Is a Potential Marker for Cellular Senescence Basetti Madhu 1 , Masako Narita 2 , Masashi Narita 2 , John R. Griffiths 1 1 Molecular Imaging, Cancer Research UK Cambridge Research Institute, Cambridge, England, United Kingdom; 2 Cellular Senescence and Tumour Suppressor Lab, Cancer Research UK Cambridge Research Institute, Cambridge, England, United Kingdom Senescence, a permanent cell cycle arrest, is thought to be a fail-safe mechanism that prevents the malignant transformation of cells; as a tumour-suppressing mechanism it shares conceptual and therapeutic similarities with the apoptosis machinery. SA-β-gal activity, elevated p53 and p16 protein levels, coupled with morphological changes are used as senescence markers, though reliable metabolic markers for senescence are still required. We present a 1 H NMR based metabolomics study of senescence induced by oncogenic Ras or MEK, or by prolonged replication, compared with growing, transformed, and quiescent cells. The data shows that phosphocholine/glycerophosphocholine ratio is a potential metabolic marker for cellular senescence. Tumor Perfusion & Permeability Hall B Monday 14:00-16:00 Computer 107 14:00 4800. The Influence of Cardiac Frequency on the Properties of the Arterial Input Function (AIF) and Computed DCE-MRI Parameter Values Rickmer Braren 1 , Yvonne Kosanke 1 , Jonas Svensson 2 , Ernst Rummeny 1 , Andreas Steingoetter 1 1 Institute of Radiology, Klinikum rechts der Isar der TU München, Munich, Germany; 2 Department of Medical Radiation Physics, Malmo University Hospital, Lund University, Malmo, Sweden DCE-CT in combination with standard MR contrast agent allows the determination of rat population AIF. This study analyzed the impact of cardiac frequency on AIF properties detected in the rat abdominal aorta and the accompanied changes in DCE-MRI parameter values. Different anesthesia induced a change of ~100 bpm in cardiac frequency which resulted in different AIF bolus shape, recirculation and washout. These in turn induced systematic errors in tumor and muscle Ktrans of 15% or 36%, respectively. In longitudinal therapy response studies, where systemic changes, due to drug treatment, are very likely to occur this phenomenon must thoroughly be considered. 14:30 4801. Histological Validation of the Cerebral Blood Volume Quantification in a C6 Brain Tumor Model Using RSST1-MRI with an Intravascular Contrast Agent: Gd-ACX Adriana-Teodora Perles-Barbacaru 1,2 , Boudewijn Van der Sanden 3 , Régine Farion 1 , Christoph Segebarth 1 , Hana Lahrech 1 1 Functional and Metabolic Neuroimaging, Grenoble Institute of Neuroscience, Grenoble, France; 2 Caltech Brain Imaging Center, Beckman Institute, Pasadena, CA, United States; 3 Rayonnement Synchrotron et Recherche Médicale, Grenoble Institute of Neuroscience, Grenoble, France The cerebral blood volume fraction (CBVf) quantification by MRI remains complex in the tumor due to the contrast agent (CA) leakage through the blood brain barrier. Gd-ACX (α-cyclodextrin complexed to gadolinium), a novel CA was shown to remain in the vascular space in a C6 brain tumor model and was used for CBVf mapping in microvasculature permeable for Gd-DOTA. Here, the use of Gd-ACX for tumor CBVf quantification was validated using histological vascular morphometry. After selecting the tumor vessels perfused by the Hoechst dye, we found a quantitative equivalence for the CBVf obtained by MRI and by vascular morphometry. 15:00 4802. Effects of Reference Tissue AIF Derived from Low Temporal Resolution DCE-MRI Data on Pharmacokinetic Parameter Estimation Marieke Heisen 1 , Xiaobing Fan 2 , Johannes Buurman 3 , Bart M. ter Haar Romeny 1 1 Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands; 2 Radiology, The University of Chicago, Chicago, IL, United States; 3 Healthcare Informatics, Philips Healthcare, Best, Netherlands Quantitative pharmacokinetic analysis of dynamic contrast enhanced (DCE) MRI clinical data is important for detection and diagnosis of cancer. For breast imaging, however, data is often acquired at low temporal resolution to enable high-spatial resolution coverage of both breasts. The effect of arterial input functions derived from low temporal resolution data on estimation of Ktrans and ve was investigated by downsampling high temporal resolution pre-clinical data in k-space. The results demonstrate that using a reference tissue AIF extracted from low temporal resolution data (till T ¡Ö 60 s) is feasible and could be used to quantitatively analyze DCE- MRI data. 15:30 4803. Dynamic Contrast-Enhanced (DCE)-MRI with Gadobutrol for Monitoring Sorafenib Effect on Experimental Prostate Carcinomas Clemens Christian Cyran 1 , Philipp Marius Paprottka 1 , Bettina Schwarz 2 , Jobst von Einem 1 , Steven Sourbron 1 , Olaf Dietrich 1 , Rabea Hinkel 3 , Christiane J. Bruns 2 , Hubertus Pietsch 4 , Bernd J. Wintersperger 1 , Maximilian F. Reiser 1 , Konstantin Nikolaou 1 1 Institute of Clinical Radiology, Munich University Hospitals - Campus Grosshadern, Munich, Germany; 2 Department of Surgery, Munich University Hospitals - Campus Grosshadern, Munich, Germany; 3 Department
of Cardiology, Munich University Hospitals - Campus Grosshadern, Munich, Germany; 4 Contrast Media Research, Bayer Schering Pharma AG, Berlin, Germany The purpose of this study was to investigate the effects of Sorafenib on experimental prostate carcinomas in rats by dynamic MRI enhanced with Gadobutrol. Target parameters were tumor perfusion and tumor endothelial permeability. Tumor perfusion (ml/100ml/min), assayed by DCE-MRI enhanced with the small molecular contrast medium Gadobutrol, decreased significantly (p
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ELECTRONIC POSTER Cartilage Hall B
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14:00 3173. Sodium MRI: A Reproduci
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15:00 3182. Comparison of Short Ech
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15:00 3191. The Application of Magn
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to unity. Conversely, in trabecular
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determination of perfusion and perm
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unique ability of UTE MRI to direct
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throughout the maturation process,
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lipoatrophy with decreased of the l
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Tuesday 13:30-15:30 Computer 6 13:3
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14:30 3258. 3D-FSE-Cube of the Foot
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15:00 3267. Dynamic Hyperpolarized
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Hall B Monday 14:00-16:00 Computer
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hyperpolarized for use as a metabol
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15:30 3295. 1 H Decoupled 13 C MRS
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use of short and high bandwidth adi
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Wednesday 13:30-15:30 Computer 10 1
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14:30 3325. Modeling of 3-Dimension
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Thursday 13:30-15:30 Computer 11 13
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14:00 3345. An Optimized T1nom Appr
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Increasing spatial resolution is ad
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14:30 3362. NMR Plasma Profiling of
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Spectroscopic Localization & Imagin
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total scan time and remove the spac
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15:00 3394. Phase-Based Contrast Ag
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Tuesday 13:30-15:30 Computer 18 13:
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15:00 3415. Modeling Neuronal Curre
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14:30 3425. A Randomized Global Sig
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15:00 3435. Investigating the Feasi
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BOLD activation within parenchymal
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15:00 3455. Understanding the Limit
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14:00 3465. Effect of EEG Electrode
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14:30 3486. Magnetization Transfer
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15:00 3506. DMN Is Affected Incongr
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the brain edge. Upon detrending thi
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healthy controls using empathy for
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14:30 3534. Single Word Reading in
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activates superior colliculus and l
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Myocardial Function Human & Experim
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14:30 3562. Cardiac Torsion and Str
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14:30 3582. Early Diastolic Strain-
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Non-Cartesian k-space trajectories
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14:30 3601. Analysis of Cardio-Resp
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15:00 3611. An Optimal Physiologic
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depending on its linear or centric
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3Tesla using a 32 channel cardiac c
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States; 5 Chemistry & Chemical Engi
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similar set of fully sampled data.
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demonstrated 35% improvement in blo
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15:00 3679. Toward a Novel Implanta
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14:30 3697. Time-Resolved Spin-Labe
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and 13 patients, including peak and
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facilitate in the robust and reprod
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accurate quantification. The -goal
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and then auto-transplanted back to
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14:30 3755. The Use of Cellular MRI
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sampling patterns which are tailore
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with potential for improving diagno
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14:30 3795. Targeted Travelling Wav
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14:30 3806. A 8 Channel TX/RX Decou
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15:00 3816. A 7T ‘Capless’ Tran
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14:30 3827. A Mechanically Tuned 8-
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Receive Arrays Hall B Monday 14:00-
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15:00 3848. A Combined Solenoid-Sur
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the past and thus yields more reali
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14:30 3870. SAR Sensitivity to Phas
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heart between 20 and 40°C. As a re
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challenges for its simultaneous com
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experimental results showed the bes
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14:30 3922. Six Layers Stripline RF
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14:30 3933. Eigenmode Analysis of E
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and a relaxed fixed point iteration
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15:00 3955. Improved PET Data Quant
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15:00 3966. Diffusion Properties of
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14:00 3985. Development of a WM Atl
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existing parallel imaging and parti
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15:00 4016. Application of Rotation
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14:30 4026. Classification of Non-G
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15:00 4036. Sensitivity of Motion E
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14:00 4046. Effects of Hypercapnia
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Arterial Spin Labeling: Methods Hal
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14:30 4066. Accounting for Dispersi
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using both methods but the differen
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estimates. Differences in delays an
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angioplasty balloon in the aorta. T
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14:30 4134. Optimal Ultrasonic Focu
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14:30 4144. TMAP @ IFE - A Framewor
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14:30 4164. Transmit Power Optimiza
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15:00 4173. Magnetic Resonance Micr
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Cell Tracking II Hall B Monday 14:0
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14:30 4192. Quantification of Cell
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15:30 4201. Characterisation of a L
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14:30 4220. Prolonged and Homogenou
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are not sensitive to early abnormal
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14:30 4240. DCE-MRI and DW-MRI in C
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15:00 4249. Are Behavioural Symptom
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were observed from the preCG and IC
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14:00 4267. Absolute Quantification
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Vergata"; 6 Cognition and Cognitive
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14:00 4283. Differentiation of Radi
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14:00 4291. Influence of Combined F
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secular-T2 peaks revealed significa
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Multiple Sclerosis I Hall B Monday
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14:30 4320. Profile-Based Cortical
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independent predictors of disabilit
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14:00 4355. In Vivo Quantitative Im
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14:30 4364. Measurement of Iron Con
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Developing Brain I Hall B Monday 14
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suggests myelination or a reduction
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15:00 4392. Dti Study in the Infant
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15:00 4401. Quantitative Analysis o
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improvements in motor deficit over
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15:00 4421. Clinical Significance o
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14:00 4431. Assessment of Cervical
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15:30 4441. Anatomical Imaging at 7
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14:00 4451. Vessel Contrast in Susc
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15:00 4461. Altered Prefrontal-Amyg
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DTI - Clinical Applications Hall B
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14:00 4479. Voxel-Based Analysis of
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14:30 4487. Diffusion Tensor Imagin
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14:30 4496. Effect of Mesenchymal S
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15:30 4505. Manganese-Enhanced MRI
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T2 and between lesion volume and AD
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significantly in rats exposed to EC
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14:30 4532. 1H MRS of Cortical and
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15:00 4541. The Impact of Gd-DTPA o
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Breast MR Hall B Monday 14:00-16:00
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Page 337 and 338: present initial results in terms of
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Page 351 and 352: 15:00 4846. The Assessment of Early
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Page 369 and 370: 1 Imaging Division, UMC utrecht, Ut
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Page 387 and 388: 14:00 5036. Real-Time Motion Correc
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15:30 5058. Reducing Ghosting in EP
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14:00 5068. Accelerated Point Sprea
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Wednesday 13:30-15:30 Computer 124
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egularization parameter is adapted
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14:00 5108. Correction Algorithm fo
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IDEAL knee MRI data is proposed. Va
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14:30 5129. Design of Iron Sensitiv
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