ELECTRONIC POSTER - ismrm

14:00 3481. High Resolution Cerebral Blood Volume Mapping in Humans at 7T with Hyperoxic
Contrast
David Thomas Pilkinton 1 , Santosh Gaddam 1 , Mark A. Elliott 1 , Ravinder Reddy 1
1 Center for Magnetic Resonance and Optical Imaging, University of Pennsylvania, Philadelphia, PA, United
States
It has recently been shown that hyperoxic contrast allows for an accurate measurement of cerebral blood volume using low resolution
(4x4x6mm) standard T2*-weighted EPI at 3T. The increase in BOLD contrast at 7T can potentially allow for significantly increased
spatial resolution with this technique. However, the standard EPI approach used at 3T is unsuitable for 7T due to shorter venous blood
T2* and increased B0 inhomogeneity. We have shown here that these problems can be addressed with steady-state acquisition
segmented 3D EPI with partial-Fourier encoding in the phase direction, which produced robust high resolution (1x1x2mm) CBV maps
at 7T.
14:30 3482. Negative Contrast Enhancement in T2*-Weighted Images of the Human Brain
During Hyperoxia
David Thomas Pilkinton 1 , Santosh Gaddam 1 , Mark A. Elliott 1 , Ravinder Reddy 1
1 Center for Magnetic Resonance and Optical Imaging, University of Pennsylvania, Philadelphia, PA, United
States
Hyperoxia is known to provide positive contrast enhancement (CE) on T2*-weighted images based on the BOLD effect. We have
shown here that hyperoxic contrast, despite producing positive CE across most of the brain, generates significant negative CE in T2*-
weighted images in inferior regions of the brain located near large arteries, even at lower FiO2 levels (