ELECTRONIC POSTER - ismrm

15:00 4401. Quantitative Analysis of the Brain Anatomy in Cerebral Palsy
Andreia Vasconcellos Faria 1,2 , Alexander Hoon 3 , Elaine Stashinko 3 , Ameneh
Mashayekh 1 , Xin Li 4 , Hangyi Jiang 1,4 , Kazi Akhter 1 , Kenichi Oishi 1 , Jiangyang Zhang 1 ,
Peter van Zijl 1,4 , Michael Miller 5 , Susumu Mori 1
1 Radiology, Johns Hopkins University, Baltimore, MD, United States; 2 Radiology, State University of
Campinas, Campinas, SP, Brazil; 3 Division of Neurology and Developmental Medicine, Kennedy Krieger
Institute, Baltimore, MD, United States; 4 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy
Krieger Institute, Baltimore, MD, United States; 5 Biomedical Engineering, Johns Hopkins University,
Baltimore, MD, United States
We developed a new method to provide a comprehensive quantitative analysis of brain anatomy in cerebral palsy patients, based on
two technical points: diffusion tensor imaging and an automated 3D whole brain segmentation based on our brain atlas and a nonlinear
normalization technique (large-deformation diffeomorphic metric mapping). This method was applied to thirteen patients and the
reliability of the automated segmentation measured by Kappa revealed "almost perfect" agreement with the manual segmentation. We
illustrate some potential applications on individual characterization and group comparison. This technique also provides a framework
to determine the impact of various neuroanatomic features on brain functions.
Thursday 13:30-15:30 Computer 81
13:30 4402. Metabolic Abnormalities in Perituberous Tissue: Initial Results of a Proton MR
Spectroscopy Study of Pediatric Tuberous Sclerosis Complex
Ivan Kirov 1 , Joseph Oved 2 , Sarah Milla 1 , Orrin Devinsky 3 , Howard Weiner 3 , Oded
Gonen 1
1 Radiology, New York University, New York, NY, United States; 2 School of Medicine, New York University,
New York, NY, United States; 3 Neurosurgery, New York University, New York, NY, United States
While traditionally the MRI-defined tuber has been the primary surgery target for abolishing seizures in Tuberous Sclerosis Complex
(TSC), there is evidence that non-tuberous tissue, specifically surrounding the active tuber, may also be epileptogenic. We use 3D
proton MR spectroscopy (1H-MRS) to characterize tubers and normal-appearing tissue. Initial results reveal metabolic abnormalities
in tubers and its adjacent tissue (peritubers). In one case electro-encephalography identified a seizure locus and 1H-MRS showed high
lipid signal in its perituberous tissue. In all, these findings have implications for improved identification and definition of the
epileptogenic zone in TSC.
14:00 4403. White Matter Microstructure Correlates with Reading Ability in Healthy Subjects
and Those with Fetal Alcohol Spectrum Disorder
Catherine Lebel 1 , Carmen Rasmussen 2 , Katy Wyper 1 , Gail Andrew 3 , Christian Beaulieu 1
1 Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada; 2 Pediatrics, University of Alberta,
Edmonton, Alberta, Canada; 3 Glenrose Rehabilitation Hospital, Edmonton, Alberta, Canada
Diffusion tensor imaging (DTI) studies of reading consistently highlight left temporal-parietal white matter. We used DTI to correlate
fractional anisotropy (FA) with reading ability in 40 subjects with fetal alcohol spectrum disorder (FASD) aged 5-19 years and 40
healthy controls. The control group had three significantly correlated clusters in the left temporal-parietal area and one in the genu (all
positive), in good agreement with previous findings. The FASD group had 9 clusters with significant correlations (3 negative, 6
positive). These included 3 left temporal-parietal clusters, showing consistent involvement in this area, but also demonstrating more
widespread correlations than controls.
14:30 4404. Pituitary Volumes and Functions in Children with Growth Hormone Deficiency:
Volumetric Magnetic Resonance Data
Miyuki Takasu 1 , Chihiro Tani 1 , Masaki Ishikawa 1 , Keizo Tanitame 1 , Hiroshi Fukuda 1 ,
Jun Horiguchi 1 , Akihisa Tamura 2 , Yoshikazu Nishi 3
1 Radiology, Hiroshima University Hospital, Hiroshima, Japan; 2 Radiology, Hiroshima Red Cross Hospital,
Hiroshima, Japan; 3 Pediatrics, Hiroshima Red Cross Hospital, Hiroshima, Japan
We investigated correlations between pituitary volumes measured from 3D volumetric MR imaging and the severity of the clinical and
biochemical features in 69 patients with growth hormone deficiency. Pituitary volumes of all patient groups were smaller than the agematched
published norms. Pituitary volumes of both female groups were significantly smaller than that of controls. Pituitary volumes
of male pubertal or postpubertal group were significantly larger than that of prepubertal one, but this difference was not significant
between female groups. IGF-1 levels were significantly correlated with pituitary volumes. LH levels were significantly correlated with
pituitary volumes in male patients.
15:00 4405. MRI Assessment of Iron-Mediated Pathology Following Juvenile Traumatic Brain
Injury
Lei Huang 1 , Arash Adami 2 , Andre Obenaus 1,3
1 Radiation Medicine, Loma Linda University, Loma Linda, CA, United States; 2 Neuroscience, University of
California, Riverside, Riverside, CA, United States; 3 Radiology, Loma Linda University, Loma Linda, CA,
United States
In a rat model of graded juvenile traumatic brain injury (jTBI), we characterized iron mediated neuropathology using multi-modal
MRI that correlated with histology and tissue iron measures. Our results showed that SWI was sensitive to monitor pathological iron