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14:00 4271. Voxel-Based Analysis of Magnetisation Transfer Ratio as a Potential Biomarker in Prion Diseases. Harpreet Hyare 1 , Enrico De Vita 2 , Gerard Ridgway 3 , Rachael Scahill 4 , Durrenajaf Siddique 1 , Simon Mead 1 , Peter Rudge 1 , Tarek Yousry 2 , John Collinge 1 , John Thornton 5 1 MRC Prion Unit, UCL Institute of Neurology, London, United Kingdom; 2 National Hospital for Neurology and Neurosurgery; 3 Dementia Research Centre, UCL Institute of Neurology; 4 Department of Neurodegenerative Diseases, UCL Institute of Neurology; 5 National Hospital for Neurology and Neurosurgery, London, United Kingdom Voxel based morphometry in inherited prion diseases demonstrates regionally specific atrophy in the basal ganglia, cerebellum and posterior cortical areas but no significant differences in the white matter compared to controls. Voxel-based analysis of magnetisation transfer ratio (MTR) demonstrates decreased MTR in the same grey matter regions but for the same threshold (p
Vergata"; 6 Cognition and Cognitive Neuroscience Group, School of Psychological Sciences, University of Manchester, United Kingdom; 7 Imaging Science & Biomedical Engineering and the Biomedical Imaging Institute, University of Manchester, United Kingdom This study assesses WM structural connectivity based on an index derived from diffusion MRI in a group of patients with Alzheimer's disease (AD), in a group of patients with amnestic mild cognitive impairment and in a group of healthy control, in order to investigate whether structural connectivity is altered in AD. The unexpected finding of increased anatomical connectivity in several subcortical areas of patients with AD but not in those with mild cognitive impairment might be explained by the neurotrophic and neurorestorative properties of the cholinesterase inhibitors assumed by these patients, although more investigations are needed. 15:00 4276. Differences Between Patients with Parkinson's Disease and Healthy Controls Detected by High Spatial Resolution 3D-MRSI at 3 T Adriane Groeger 1 , Grzegorz Chadzynski 2 , Kathrin Brockmann 1 , Karin Srulijes 1 , Daniela Berg 1 , Uwe Klose 2 1 Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany; 2 Department for Diagnostic and Interventional Neuroradiology, Section for Experimental Magnetic Resonance of Central Nervous System, University of Tuebingen, Tuebingen, Germany We developed an optimized 3D-MRSI protocol with high spatial resolution at 3T to evaluate a method for assessing the characteristic loss of neurons inside the substantia nigra in patients with Parkinson’s disease. Nine PD patients and eight age-matched healthy controls were examined. A voxel size of 0.252 ml yielded reproducible values for the NAA/Cr ratios in all subjects. Our results show clear differences between the intra-individual NAA/Cr ratios in the SN of PD patients compared to controls and suggest that aspects of the pathophysiological process at the SN can be assessed by 3D-MRSI with high spatial resolution at 3T. 15:30 4277. Diffusion Tensor Imaging Detection of Early White Matter Changes in an Accelerated SIV Primate Model of NeuroAIDS Eva-Maria Ratai 1,2 , Vadim Villarroel 3 , Julian He 1,2 , Reza Hakimelahi 1,2 , Robert Fell 1 , Chan-Gyu Joo 1,2 , Jeffrey Bombardier 1 , Susan Westmoreland, 2,4 , Kenneth Williams 5 , Ramon Gilberto Gonzalez 1,2 1 Department of Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States; 2 Harvard Medical School, Boston, MA, United States; 3 Johns Hopkins School of Medicine, Baltimore, MD, United States; 4 Division of Comparative Pathology, New England Primate Research Center, Southborough, MA, United States; 5 Biology Department, Boston College, Boston, MA, United States A significant number of HIV-infected patients develop neurological symptoms which are thought to be a result of injury to neurons in the CNS. Our objective was to use DTI to detect abnormalities in white matter in a SIV-infected, CD8-depleted macaque model of neuroAIDS. MRS and DTI were conducted before and at 2 and 4 weeks post infection. White matter in the corpus callosum showed a trend towards decreased FA at 2 wpi. Correlation analyses demonstrated a significant association between white matter damage in the splenium and increases in choline. FA showed a negative correlation with viral load in the CSF. Clinical Brain Tumor Imaging Hall B Monday 14:00-16:00 Computer 74 14:00 4278. 1 H-HRMAS of Small-Molecule-Metabolites in Adult Brain Tumours: Assignment, Quantification and Biomarker Determination. Alan Wright 1 , Greg A. Fellows 2 , John R. Griffiths 3 , Martin Wilson 4,5 , B Anthony Bell 2 , Franklyn Arron Howe 2 1 Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; 2 St George's University of London, United Kingdom; 3 CRUK Cambridge Research Institute, United Kingdom; 4 University of Birmingham, United Kingdom; 5 Birmingham Children’s Hospital NHS Foundation Trust, United Kingdom MRS has the potential to provide diagnostic and prognostic biomarkers for brain tumours in vivo. We have used the ex vivo technique of 1 H HRMAS NMR spectroscopy of brain tumour samples to identify the “NMR visible” metabolites in the common adult brain tumours. This has lead to the identification of 29 small molecule metabolites observable in spectra from a set of 65 tumours including grade II astrocytomas, grade III gliomas, GBMs, lymphomas, metastases and meningiomas. We have also identified some novelpotential biomarkers for binary brain-tumour diagnostic comparisons. These include hypotaurine as a marker for GBM when compared to metastases or histidine as a positive marker for gliomas when compared to metastases or meningioma.
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ELECTRONIC POSTER Cartilage Hall B
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14:00 3173. Sodium MRI: A Reproduci
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15:00 3182. Comparison of Short Ech
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15:00 3191. The Application of Magn
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to unity. Conversely, in trabecular
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determination of perfusion and perm
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unique ability of UTE MRI to direct
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throughout the maturation process,
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lipoatrophy with decreased of the l
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Tuesday 13:30-15:30 Computer 6 13:3
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14:30 3258. 3D-FSE-Cube of the Foot
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15:00 3267. Dynamic Hyperpolarized
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Hall B Monday 14:00-16:00 Computer
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hyperpolarized for use as a metabol
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15:30 3295. 1 H Decoupled 13 C MRS
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use of short and high bandwidth adi
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Wednesday 13:30-15:30 Computer 10 1
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14:30 3325. Modeling of 3-Dimension
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Thursday 13:30-15:30 Computer 11 13
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14:00 3345. An Optimized T1nom Appr
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Increasing spatial resolution is ad
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14:30 3362. NMR Plasma Profiling of
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Spectroscopic Localization & Imagin
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total scan time and remove the spac
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15:00 3394. Phase-Based Contrast Ag
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Tuesday 13:30-15:30 Computer 18 13:
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15:00 3415. Modeling Neuronal Curre
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14:30 3425. A Randomized Global Sig
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15:00 3435. Investigating the Feasi
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BOLD activation within parenchymal
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15:00 3455. Understanding the Limit
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14:00 3465. Effect of EEG Electrode
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14:30 3486. Magnetization Transfer
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15:00 3506. DMN Is Affected Incongr
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the brain edge. Upon detrending thi
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healthy controls using empathy for
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14:30 3534. Single Word Reading in
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activates superior colliculus and l
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Myocardial Function Human & Experim
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14:30 3562. Cardiac Torsion and Str
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14:30 3582. Early Diastolic Strain-
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Non-Cartesian k-space trajectories
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14:30 3601. Analysis of Cardio-Resp
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15:00 3611. An Optimal Physiologic
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depending on its linear or centric
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3Tesla using a 32 channel cardiac c
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States; 5 Chemistry & Chemical Engi
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similar set of fully sampled data.
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demonstrated 35% improvement in blo
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15:00 3679. Toward a Novel Implanta
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14:30 3697. Time-Resolved Spin-Labe
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and 13 patients, including peak and
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facilitate in the robust and reprod
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accurate quantification. The -goal
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and then auto-transplanted back to
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14:30 3755. The Use of Cellular MRI
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sampling patterns which are tailore
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with potential for improving diagno
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14:30 3795. Targeted Travelling Wav
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14:30 3806. A 8 Channel TX/RX Decou
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15:00 3816. A 7T ‘Capless’ Tran
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14:30 3827. A Mechanically Tuned 8-
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Receive Arrays Hall B Monday 14:00-
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15:00 3848. A Combined Solenoid-Sur
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the past and thus yields more reali
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14:30 3870. SAR Sensitivity to Phas
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heart between 20 and 40°C. As a re
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challenges for its simultaneous com
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experimental results showed the bes
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14:30 3922. Six Layers Stripline RF
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14:30 3933. Eigenmode Analysis of E
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and a relaxed fixed point iteration
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15:00 3955. Improved PET Data Quant
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15:00 3966. Diffusion Properties of
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14:00 3985. Development of a WM Atl
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existing parallel imaging and parti
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15:00 4016. Application of Rotation
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Page 195 and 196: angioplasty balloon in the aorta. T
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15:30 4505. Manganese-Enhanced MRI
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T2 and between lesion volume and AD
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significantly in rats exposed to EC
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14:30 4532. 1H MRS of Cortical and
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15:00 4541. The Impact of Gd-DTPA o
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Breast MR Hall B Monday 14:00-16:00
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therapies. MRI characteristics of t
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15:30 4569. Characterization of Cir
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information is a novel approach. Th
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15:00 4589. Assessment of Liver Oxy
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14:30 4599. Producing Hyperpolarize
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14:30 4608. Improvement of Multisli
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14:30 4636. Chronic Hepatitis and F
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Metabolism Liver & Other II Hall B
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14:00 4655. Utilizing Magnetic Reso
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14:30 4684. Long Term Follow-Up of
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15:00 4693. Renal Blood Flow Change
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Wednesday 13:30-15:30 Computer 100
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Body Diffusion Hall B Monday 14:00-
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14:30 4720. Comparison of Simulatio
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14:00 4730. Proton MRS of Changes o
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15:00 4740. Histopathological Compo
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prevention. In this study we have e
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15:00 4758. Quantitative Analysis o
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15:00 4767. DCE-MRI for the Detecti
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Tuesday 13:30-15:30 Computer 105 13
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present initial results in terms of
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14:30 4794. Bax-Deficiency Reduces
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of Cardiology, Munich University Ho
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appropriately describes the uptake
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tumour. A significant reduction in
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14:30 4838. Detection and Improveme
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15:00 4846. The Assessment of Early
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Our results indicate that the propo
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egularizing terms that may affect t
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times due to the need of additional
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proposed homotopic L0 minimization
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15:00 4910. Auto-Calibrated Paralle
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14:30 4921. Sparse Parallel Transmi
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1 Imaging Division, UMC utrecht, Ut
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frequency k-space data are processe
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cylinders trajectory and have imple
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still requires scan durations not a
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15:00 5006. A T 2 * Selective Highe
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14:00 5016. High Spatial and Tempor
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14:00 5036. Real-Time Motion Correc
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perform the AC of the SPECT data. T
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15:30 5058. Reducing Ghosting in EP
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14:00 5068. Accelerated Point Sprea
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egularization parameter is adapted
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14:00 5108. Correction Algorithm fo
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IDEAL knee MRI data is proposed. Va
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14:30 5129. Design of Iron Sensitiv
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