ELECTRONIC POSTER - ismrm

14:00 4655. Utilizing Magnetic Resonance Elastography in the Evaluation of Liver Donors
Tilina Hu 1 , Alvin Silva 1 , Leland Hu 1 , Richard Ehman 2
1 Radiology, Mayo Clinic, Scottsdale, AZ, United States; 2 Radiology, Mayo Clinic, Rochester, MN, United
States
To determine accurate biopsy-validated Magnetic Resonance Elastography threshold values that distinguish normal from abnormal
liver (due to fibrosis and/or inflammation). We focus specifically on pre-operative evaluation of liver donors prior to transplant.
14:30 4656. DTI and 2D MR Spectroscopy of Hepatitis C in 3T
Rajakumar Nagarajan 1 , Manoj K. Sarma 1 , Charles Hinkin 2 , Steven Castellon 2 , Jason P.
Smith 3 , Homayoon Khanlou 4 , Laveeza Bhatti 4 , Jonathan Truong 5 , Ann B. Ragin 6 , Elyse
Singer 7 , M Albert Thomas 1
1 Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States; 2 Department of
Psychiatry & Biobehavioral Sciences, UCLA School of Medicine and VA Greater Los Angeles Healthcare
System, Los Angeles, CA, United States; 3 Veteran's Affairs Greater Los Angeles Healthcare Center; 4 AIDS
Healthcare Foundation, Westside Clinic, Los Angeles; 5 Kaiser Permanente, Lancaster CA; 6 Northwestern
University, Chicago, Illinois, USA; 7 Neurology, UCLA School of Medicine, Los Angeles, California, United
States
Hepatitis C is a liver disease caused by the hepatitis C virus (HCV). HCV infection sometimes results in an acute illness, but most
often becomes a chronic condition that can lead to cirrhosis of the liver and liver cancer. Hepatitis C may be detectable with MR
diffusion tensor imaging (DTI), which is exquisitely sensitive to water diffusion and is used to quantify the magnitude of diffusivity
and the orientation and linearity (that is, anisotropy) of water motility in microstructural level in brain. Combining two-dimensional
(2D) localized correlated spectroscopic (L-COSY) technique with DTI provides more information about the cerebral metabolites,
mean diffusivity and fractional anisotropy changes in patients with hepatitis C.
15:00 4657. Estimation of Liver Iron Content with Different MRI Methods
Arthur Peter Wunderlich 1 , Holger Cario 2 , Mathias Schmid 3 , Markus Juchems 1
1 Dept. for Diagnostic and Interventional Radiology, Univ.-Clinic Ulm, Ulm, Baden-Württemberg, Germany;
2 Pediatrics, Univ.-Clinic Ulm, Ulm, Germany; 3 Hematology, Univ.-Clinic Ulm, Ulm, Germany
To compare the liver iron content (LIC) determined by different MR methods, we investigated 93 patients with protocols according to
three published methods, two using gradient echo (GRE) sequences and one working with spin echo (SE). The methods correlate
moderately with r=0.82. Weakpoints are the bad performance of one GRE method near its upper limit and the sensitivity to liver
steatosis of the GRE method addressing high LIC. The latter leads to reduced correlation of SE vs. GRE in the high LIC range.
Although GRE generally tends to overestimate LIC, both methods are suitable for decisions concerning patient management.
Thursday 13:30-15:30 Computer 97
13:30 4658. Is Shear Viscosity a Sign for Malignancy in Liver Tumours?
Jean Luc Daire 1 , Ralph Sinkus 2 , Mathilde Wagner 1 , Nathalie Haddad 1 , Valerie Vilgrain 1 ,
Bernard van Beers 1
1 INSERM U773, CRB3 Centre de Recherches Biomédicales Bichat-Beaujon, Paris, France; 2 Institut Langevin,
ESPCI, Paris, France
Liver tumours are very frequent. They include benign lesions and malignant primary or secondary tumours (metastases). Currently,
there is no established non-invasive imaging Goldstandard available in order to characterize malignancy for liver tumours. Very often,
the enhancement characteristics of a bolus are used in order to differentiate benign from malignant tumours. Here, we intend to
prospectively evaluate the complex shear modulus as measured via MR-elastography in the assessment of malignancy or benignity of
liver lesions and compare its performance to those of three enhancement characteristics of the bolus passage.
14:00 4659. Evaluation of Nonalcoholic Liver Disease Using 23 Na MRI and Shift Reagent-Aided
23 Na and 31 P MRS
Paige Nicole Hopewell 1,2 , Navin Bansal 1,2
1 Radiology, Indiana University School of Medicine, Indianapolis, IN, United States; 2 Weldon School of
Biomedical Engineering, Purdue University, West Lafayette, IN, United States
Changes in signal intensity with disease progression in single quantum (SQ) and triple quantum-filtered (TQF) 23 Na MRI are validated
with shift reagent-aided SQ and TQF 23 Na and 31 P MRS studies in a nonalcoholic fatty liver disease model. Changes in intracellular
Na + concentration and fibrosis-associated macromolecule deposition in the extracellular space both contribute to an increased TQF
23 Na MRI signal with advanced disease progression.
14:30 4660. Liver Fibrosis Grading Based on MR Elastography and 31P Spectroscopy
Edmund Mark Godfrey 1 , Anant S. Krishnan 1 , Susan E. Davies 2 , Nyree M. Griffin 3 ,
Graeme J. Alexander 4 , Mike E. Allison 4 , Alexander E. Gimson 4 , William H. Griffiths 4 ,
David J. Lomas 1
1 Department of Radiology, Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom;
2 Department of Histopathology, Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom;