ELECTRONIC POSTER - ismrm

Tuesday 13:30-15:30 Computer 100
13:30 4698. Renal Cell Carcinoma: 3.0-T Diffusion-Weighted MR Imaging for Subtypes
Differentiation
Haiyi Wang 1 , Aitao Guo 2 , Dianjun Wang 2 , Yuangui Gao 1 , Xu Zhang 3 , Huiyi Ye 1
1 Radiology, PLA General Hospital, Beijing, China; 2 Pathology, PLA General Hospital, Beijing, China;
3 Urology, PLA General Hospital, Beijing, China
Renal cell carcinoma (RCC) is the most common malignant renal tumor in adults, with the three major subtypes, clear cell RCC,
papillary RCC, and chromophobe RCC. Because of clincal needs for RCC subtypes differentiation, this study explores the ADC
values of pathologically-proved clear cell, papillary, and chromophobe RCC subtypes, and the conclusion is drawn that they possess
different diffusion characteristics that can be distinguished using DWI on the basis of the ADC, with high sensitivity and specificity,
potentially improving the accuracy of pretreatment diagnosis and selection of clinical therapy.
14:00 4699. Evaluation of 3.0T MR Diffusion-Weighted Imaging in Diagnosis and Short-Term
Therapeutic Effect of Renal Clear Cell Carcinoma
Xiao-duo Yu 1 , Meng Lin 1 , Han Ouyang 1
1 Department of Diagnostic Imaging, Cancer Hospital,Peking Union Medical College,Chinese Academy of
Sciences, Beijing, China
DWI and ADC value in 3.0T MRI has widely used in tumor, but applied to clinical practice limitedly for overlap between benign and
malignant tumor. 51 cases with renal clear cell carcinoma proved by operation were studied. Set ADC value at 1.8×10-3mm²/s to
divide the cohort into two groups. Significant differences were found between histological grade, clinical stage. After follow-up more
than one year, tumor short-term control rate of the group with ADC value more than and equal to 1.8×10-3mm²/s was better than that
of the group with ADC value less than 1.8×10-3mm²/s.Therefore DWI and ADC value help to evaluate prognosis potentially.
14:30 4700. Diffusion Weighted Imaging with Biexponential Analysis of Intravoxel Incoherent
Motion in Assessment of Renal Lesions: Preliminary Experience
Hersh Chandarana 1 , Vivian S. Lee 1 , Elizabeth Hecht 1,2 , Bachir Taouli 1,3 , Eric E.
Sigmund 1
1 Radiology, NYU Langone Medical Center, New York, NY, United States; 2 Radiology, University of
Pennsylvania, United States; 3 Radiology, Mount Sinai Medical Center, New York, NY, United States
Movement of blood in microvasculature can be modeled as pseudo-diffusion also known as intravoxel incoherent motion. Perfusion
effect can be separated if diffusion imaging is performed with low and high b values. The purpose of our study was to calculate
perfusion fraction (fp) and tissue diffusivity (Dt) parameters obtained with biexponential analysis of multi-b DWI and determine if
these parameters can distinguish enhancing from non-enhancing renal lesions. fp was higher and Dt lower in enhancing renal lesions;
both these parameters had higher accuracy in detection of enhancing renal lesion compared to apparent diffusion coefficient (ADC)
obtained with monoexponential fit.
15:00 4701. Loss of Renal Diffusion Anisotropy in Patients with Chronic Kidney Disease
Yu-Chun Lin 1,2 , Koon-Kwan Ng 1 , Tzung-Hai Yen 3 , Yu-Min Chen 3 , Hsiang-Yang Ma 2 ,
Jiun-Jie Wang 4
1 Department of Diagnostic Radiology, ChangGung Memorial Hospital, KweiShan, Taoyuan, Taiwan;
2 Department of Electrical Engineering, ChangGung University, KweiShan, Taoyuan, Taiwan; 3 Department of
Nephrology, ChangGung Memorial Hospital, Taiwan; 4 Department of Medical Imaging and Radiological
Science, ChangGung University, KweiShan, Taoyuan, Taiwan
Diffusion Tensor Imaging in kidney for patients with chronic kidney disease indicated a significant reduction of diffusion anisotropy.
Images from 6 CKD patients and 6 normal subjects were acquired in a 3 Tesla MR scanner. Regions of interest were located
bilaterally in medulla and cortex. The results showed decreases in diffusion anisotropy and associated increase in radial diffusivity,
noticeably in medulla in patients. We concluded that renal DTI is feasible in 3T MR scanner and furthermore, sensitive to changes in
diffusivities in patients with chronic kidney disease.