14:30 4492. Characterization of Mild Hypoxic-Ischemic Injury in Multiple White Matter Tracts in a Neonatal Rat Model by Diffusion Tensor MR Imaging Silun Wang 1,2 , ED X. WU 3 , Ho-fai Lau 3 , Jing Gu 1 , Jinyuan Zhou 2 , Pek-lan Khong 1 1 Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong; 2 Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; 3 Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, Hong Kong We evaluated hypoxic-ischemic (HI)-induced white matter (WM) injury in a mild HI neonatal rat model from Day1 to 90 post-HI by DTI. Results showed that significantly decreased FA in multiple injured WM tracts, including external capsule (EC), fornix (F), cerebral peduncle (CP) and optical tracts (OT), at different time points, but no differences were demonstrated in anterior commissure (AC). Our results support the use of DTI as an imaging biomarker to non-invasively monitor the severity and longitudinal changes of mild HI-induced WM injury. Different severity and patterns of WM tract injury may reflect disturbances of cerebral blood supply in this ischemic animal model. 15:00 4493. DTI of Adult Visual Pathways After Severe Neonatal Hypoxic-Ischemic Cerebral Injury Kevin C. Chan 1,2 , Abby Y. Ding 1,2 , Ed X. Wu 1,2 1 Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China; 2 Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China This study employs in vivo diffusion tensor imaging (DTI) to determine the long-term outcomes of microstructural integrity along the visual pathways after severe neonatal hypoxic-ischemic (HI) injury to the entire ipsilesional visual cortex in rats at postnatal day 7. Quantitative analyses showed that, compared to age-matched normal brains, a significantly lower FA but higher λ//, λ┴ and diffusion trace value were observed in the ipsilesional posterior optic tract in the HI-injured brains at postnatal day 60, whereas significantly lower FA but mildly lower λ// and higher λ┴ and trace were observed in the ipsilesional prechiasmatic optic nerve and contralesional anterior and posterior optic tracts. The results of this study are potentially important in determining and improving the functional consequences of the brain lesion after most compensatory and reparative phases have been passed. Wednesday 13:30-15:30 Computer 87 13:30 4494. Comparison of MRI Measured Mean Micro-Vessel Segment Length and Micro- Vessel Radius and Laser Scan Confocal Microscopy After Embolic Stroke Asamoah Bosomtwi 1,2 , Quan Jiang 2,3 , Li Zhang 2 , Zheng Gang Zhang 2,3 , Michael Chopp 2,3 1 Yerkes Imaging Center, Emory University, Atlanta, GA, United States; 2 Neurology, Henry Ford Hospital, Detroit, MI, United States; 3 Physics, Oakland University, Rochester, MI, United States We investigated vascular remodeling after stroke using MRI mean segment length (MSL) and vessel size index (VSI) measurement and correlate the results with measurements using Laser Scanning Confocal Microscopy (LSCM). We demonstrate that MRI MSL and VSI can detect the microvascular status of brain tissue with different ischemic damage. The MSL and VSI measured by MRI were highly correlated with LSCM histological measurements. Our data demonstrate that these MRI measurements can quantitatively evaluate microvascular remodeling after stroke. 14:00 4495. Cell-Based Treatment Induced White Matter Reorganization After Traumatic Brain Injury Measured by Gaussian, Q-Space DTI, and Histology Quan Jiang 1,2 , Guang Liang Ding, Siamak Pourabdollah-Nejad 1 , Chang Sheng Qu 3 , Asim Mahmood 3 , Li Zhang 1 , Zheng Gang Zhang 1 , Jiani Hu 4 , Nassan Bagher-Ebadian 1 , James R. Ewing 1 , Michael Chopp 1,2 1 Neurology, Henry Ford Health System, Detroit, MI, United States; 2 Physics, Oakland University, Rochester, MI, United States; 3 Neurosurgery, Henry Ford Health System, Detroit, MI, United States; 4 MR Center, Wayne State University, Detroit, MI, United States We investigated cell-based treatment induced white matter remodeling after traumatic brain injury (TBI) using Gaussian, q-ball, standard deviation (SD) DTI, and immuno-histochemistry staining. We demonstrate that in brain tissue with a preponderance of single oriented fibers, Gaussian DTI can correctly identify white matter reorganization and detect changes of axonal orientation in the boundary recovery region after TBI. However, SD and q-ball need to be employed to measure WM reorganization if substantial fiber crossing is present in the recovery tissue. Our data suggest that combination SD and FA data may provide information about the stage of white matter remodeling after TBI.
14:30 4496. Effect of Mesenchymal Stem Cells on the Cerebral Microvascularisation in a Rat Model of Stroke: MRI Study Anaick Moisan 1 , Emmanuelle Grillon 1 , Emmanuel L. Barbier 1 , Florence De Fraipont 2 , Chantal Remy 1 , Marie-Jeanne Richard 2,3 , Olivier Detante 1,4 1 INSERM U836 / Joseph Fourier University (Functional and Metabolic Imaging), Grenoble Institute of Neurosciences (GIN), Grenoble, France, Metropolitan; 2 INSERM U823 / Joseph Fourier University, Albert Bonniot Institute, Grenoble, France, Metropolitan; 3 Cell and Tissue Therapy Unit, University Hospital, Grenoble, France, Metropolitan; 4 Stroke Unit, Department of Neurology, University Hospital, Grenoble, France, Metropolitan In a rat model of stroke, the effects of human mesenchymal stem cells (hMSC) on the evolution of microvascularisation were studied. Seven days after transient cerebral ischemia, rats received a 10µL intracerebral administration of either cell culture medium or 4×105 hMSC. Two groups of healthy control rats underwent the same treatment. Groups were followed by MRI during 21 days (ADC, cerebral blood volume (CBV), vessel size (VSI)). One day after IC administration, hMSC abolish the CBV increase commonly observed after transient cerebral ischemia. VSI estimates suggest that hMSC also delay the vasodilation secondary to cerebral ischemia. 15:00 4497. Microvascular Density Quantitative Changes After Rat Embolic Stroke Using MRI Asamoah Bosomtwi 1,2 , Quan Jiang 2,3 , Guanlian Ding 2 , Li Zhang 2 , Zheng Gang Zhang 2,3 , Mei Lu 4 , James R. Ewing 2,3 , Michael Chopp 2,3 1 Yerkes Imaging Center, Emory University, Atlanta, GA, United States; 2 Neurology, Henry Ford Hospital, Detroit, MI, United States; 3 Physics, Oakland University, Rochester, MI, United States; 4 Biostatistics and Research Epidemiology, Henry Ford Hospital, Detroit, MI, United States We investigated vascular remodeling after stroke using MRI microvascular density (MVD) measurement and gold standard immunohistochemistry staining. We demonstrate that MRI MVD detect the microvascular status of brain tissue with different ischemic damage. The MVD measured by MRI was highly correlated with histological measures of MVD. Our data demonstrate that MRI MVD measurement can quantitatively evaluate microvascular remodeling after stroke. Thursday 13:30-15:30 Computer 87 13:30 4498. Stem Cell Treatment of Hemorrhagic Lesions Investigated by Longitudinal DTI Study of a Monkey Model Chenlu Feng 1 , Qinyu Zeng 1 , Zhengguang Chen 2 , Tie-Qiang Li 3 , Xiaoming Yin 1 , Jianwei Huo 1 , Ming Feng 4 , Renzhi Wang 4 1 Department of Radiology, Beijing Coal General Hospital, Beijing, China; 2 Department of Radiology, First Hospital of Tsinghua University, Beijing, China; 3 Department of Medical Physics, Karolinska University Hospital, Stockholm, Sweden; 4 Department of Neurosurgery, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China The treatment of hemorrhagic lesion with neuronal stem cell procedure was studied by diffusion tensor imaging in a monkey model using a clinical 3T MRI system. The longitudinal changes of the fractional anisotropy indicate that the procedure at the dosage of 0.5- 2.5 million cells is very effective and DTI is a useful tool to monitor the time course of the neuronal repair and fiber track regeneration process. 14:00 4499. Cerebral Blood Volume Imaging of Spreading Depression in S218L Mouse Model of Familial Hemiplegic Migraine Type 1 Kwangyeol Baek 1,2 , Katherina Eikermann_Haerter 3 , Woo Shim 1,2 , Cenk Ayata 3 , Guangping Dai 1 , Jeong Kon Kim 4 , Bruce R. Rosen 1 , Jaeseung Jeong 2 , Young Ro Kim 1 1 Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States; 2 Bio and Brain Engineering, KAIST, Daejeon, Korea, Republic of; 3 Radiology, Massachusetts General Hospital, Charlestown, MA, United States; 4 Radiology, Asan Medical Center, Seoul, Korea, Republic of Spreading depression (SD) is a propagating wave of cellular depolarization, and implicated in pathophysiology of migraine and periinfarct depolarization. In last decade, MRI started to be used for non-invasive imaging of SD, but not much is known about the neurovascular coupling in SD, especially for subcortical regions. We investigated CBV changes induced by SD in cortical and subcortical regions using intravenous contrast agent. We observed marked CBV increase (up to 20%) in cortex, striatum, and hippocampus, but not in thalamus. The CBV response gradually reached peak ~5 min after the neuronal depolarization, suggesting neurovascular coupling is largely modified in SD. 14:30 4500. The Quantification of Tissue Sodium Concentration Using 23 Na-Magnetic Resonance Microscopy at 7 T: Probing the Acute Stroke Phase Friedrich Wetterling 1,2 , Lindsay Gallagher 3 , Mhairi I. Macrae 4 , Sven Junge 5 , Andrew John Fagan, 1,6 1 School of Physics, Trinity College Dublin, Dublin, Ireland; 2 Computer Assisted Clinical Medicine, University of Heidelberg, Mannheim, Germany; 3 Glasgow Experimental MRI Centre, , Division of Clinical Neuroscience, Faculty of Medicine, University of Glasgow, Glasgow, Scotland, United Kingdom; 4 Glasgow Experimental MRI Centre, Division of Clinical Neuroscience, Faculty of Medicine, University of Glasgow, Glasgow,
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prevention. In this study we have e
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present initial results in terms of
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of Cardiology, Munich University Ho
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1 Imaging Division, UMC utrecht, Ut
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