ELECTRONIC POSTER - ismrm
ELECTRONIC POSTER - ismrm
ELECTRONIC POSTER - ismrm
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14:30 4364. Measurement of Iron Concentration in Human Brain Using Quantitative<br />
Susceptibility Mapping (QSM): Correlation with Age<br />
Tian Liu 1,2 , Jing Liu 2 , Ludovic de Rochefort 3 , James Ledoux 2 , Qing Zhang 4 , Martin R.<br />
Prince 2 , Jianlin Wu 4 , Yi Wang 1<br />
1 Biomedical Engineering, Cornell University, New York, NY, United States; 2 Radiology, Weill Cornell<br />
Medical College, New York, NY, United States; 3 MIRCen, I2BM, DSV, CEA, Fontenay-aux-Roses, France;<br />
4 Radiology, The 1st Hospital of Dalian Medical University, Dalian, Liaoning, China<br />
Increasing iron deposition with increasing age has been confirmed in postmortem studies and observed in in vivo MRI. In this 100<br />
volunteer study, we specifically measured susceptibility in putamen, and converted it to Fe3+ concentration. A strong linear<br />
correlation was obtained between susceptibility and age. The iron concentration agreed well with postmortem results.<br />
15:00 4365. Improved Inter-Subject Functional Registration Using DARTEL in Individuals<br />
Prenatally Exposed to Alcohol<br />
Priya Santhanam 1 , Zhihao Li 1 , Claire Coles 2 , Mary Ellen Lynch 2 , Xiaoping Hu 1<br />
1 Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, GA,<br />
United States; 2 Department of Psychiatry and Behavioral Sciences, Emory University<br />
On account of multifaceted structural damage induced by prenatal alcohol exposure (PAE), MR image registration problems have<br />
been a roadblock in the detailed analysis of images from this population. The present study examines the applicability of DARTEL<br />
(diffeomorphic anatomical registration through exponentiated lie algebra) to functional image registration in the PAE population. As<br />
compared to Talairach transformation, functional image registration by DARTEL had more group difference clusters in expected<br />
regions, and significant correlation between intensity over one difference cluster and known exposure-related measures. Results imply<br />
DARTEL may be a more accurate method for functional image registration for the PAE population.<br />
Wednesday 13:30-15:30 Computer 79<br />
13:30 4366. Do Differences in Myelin Underlie the The Schizotypal Personality Spectrum?<br />
Katrina McMullen 1 , Shannon Kolind 1,2 , Emma Barkus 3 , Sean CL Deoni 1<br />
1 Centre for Neuroimaging Sciences, Institute of Psychiatry, London, England, United Kingdom; 2 Centre for<br />
Functional Magnetic Resonance Imaging of the Brain, Oxford University, Oxford, England, United Kingdom;<br />
3 Department of Psychiatry, University of Wollongong, NSW, New South Wales, Australia<br />
Alterations in region grey matter volume, white matter structure and brain function are known associates schizophrenia and<br />
schizophrenia spectrum disorders. However, the underlying etiology of these disorders, believed to represent a spectrum of psychosis<br />
proneness, remains unknown. Increasingly, the role of white matter connectivity, mediated by myelin, to these disorders is being<br />
questioned. Here we report on a study of myelin content in schizotypy, revealing a linear association between schizotypy score and<br />
myelin water fraction, localized to the left hemisphere. These results, consistent with prior fMRI results, are suggestive of altered<br />
white matter efficiency and processing ability in high schizotypes.<br />
14:00 4367. Clinical 1H MRS Studies of Glutamatergic Neurotransmission in Bipolar Disorder<br />
Wen-Jang Chu 1,2 , Mathew Norris 3 , Renu Kotwal, Caleb M. Adler, Mi-Jung Kim, Rachel<br />
Whitsel, Jing-Huei Lee, 23 , Melissa P. DelBello, Stephen M. Strakowski, 2<br />
1 Psychiatry, Univ. of Cincinnati, Cincinnati, OH, United States; 2 Center for Imaging Research, Univ. of<br />
Cincinnati, Cincinnati, OH, United States; 3 Biomedical Engineering, Univ. of Cincinnati<br />
Glutamate (Glu) has been found play an important role in Bipolar Disorder (BD). The accurate measurement of Glu has been hurdled<br />
by the large signals overlapping and broadening baseline. Instead of reporting Glu levels, the Glx (sum of glutamate, glutamine and<br />
GABA) has been widely used in glutamatergic neurotransmission research. In this work, we studied Glu levels using short echo<br />
PRESS spectroscopy, and TE-averaged spectroscopy in medication-free, lithium-treated BD patients and healthy volunteers. The<br />
results have allowed us to evaluate the Glu level differences between the two groups, and the effect of lithium treatment on Glu levels.<br />
14:30 4368. Impaired Brain Circuitry and High-Energy Phosphates in Bipolar Disorder<br />
Wen-Jang Chu 1,2 , Amanda Stover 3 , Jonathan Dudley 4 , David Caldwell 2 , Amanda Marie<br />
Opaskar 2 , Mathew Norris 4 , Martine Lamy 2,3 , Jane Allendorfer 2,3 , Stephen M.<br />
Strakowski 1,2 , Jing-Huei Lee 2,4 , James C. Eliassen 1,2<br />
1 Psychiatry, Univ. of Cincinnati, Cincinnati, OH, United States; 2 Center for Imaging Research, Univ. of<br />
Cincinnati, Cincinnati, OH, United States; 3 Graduate Program in Neuroscience, Univ. of Cincinnati;<br />
4 Biomedical Engineering, Univ. of Cincinnati<br />
The combined approach of fMRI and 31P spectroscopy is used to investigate 1) abnormal brain activation, and 2) the correlation<br />
between high-energy phosphates and abnormal activation in the brains of patients with bipolar disorder. A behavioral task, the Balloon<br />
Analogue Risk Task, was used during fMRI to identify brain regions that differed between bipolar and healthy subjects. Several<br />
regions within anterior limbic network such as amygdala, ventrolateral prefrontal cortex and orbitofrontal cortex were identified by<br />
fMRI activation differences. 31P MRSI data showed significant alterations of Pi, PDE and PCr in some of these regions.