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Tuesday 13:30-15:30 Computer 80 13:30 4378. Evolving Modular Structures During Early Functional Brain Development Wei Gao 1 , Hongtu Zhu 2 , John Gilmore 3 , Weili Lin 4 1 Biomedical Engineering, UNC-Chapel Hill, Chapel Hill, NC, United States; 2 Biostatistics and Biomedical Research Imaging Center, University of North Carolina-Chapel Hill; 3 Psychiatry, University of North Carolina- Chapel Hill; 4 Radiology and Biomedical Research Imaging Center, University of North Carolina-Chapel Hill The integrated action between functionally connected yet spatially distributed regions to form different ¡°modules¡± is central to normal brain function. Numerous studies have been performed to detect possible brain modules supporting specific functions including sensory processing and the higher level cognition in adults. However, the formation of modular structures is likely to be substantially influenced by both structural maturation and learning, particularly during the early stage of brain development. In this study, healthy pediatric subjects 2 wks to 2 yrs of age were recruited and modularity analysis was performed to discern whole brain functional networks so as to delineate the emerging and developing trajectory of brain modular structures in a critical time period of early brain development. 14:00 4379. Diffuse Microstructural Abnormalitites in Non-Cystic Focal White Matter Necrosis Arabhi C. Nagasunder 1 , Lisa Paquette 2 , Caroline Jane Tavare 3 , Tena Rosser 4 , Floyd H. Gilles 3 , Marvin D. Nelson 1 , Stefan Bluml 1,5 , Ashok Panigrahy 1,6 1 Department of Radiology, Childrens Hospital Los Angeles, Los Angeles, CA, United States; 2 Division of Neonatology, Childrens Hospital Los Angeles, Los Angeles, CA, United States; 3 Department of Neuropathology, Childrens Hospital Los Angeles, Los Angeles, CA, United States; 4 Division of Neurology, Childrens Hospital Los Angeles, Los Angeles, CA, United States; 5 Rudi Schulte Research Institute, Santa Barbara, CA, United States; 6 Department of Radiology, Childrens Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States Neonatal brain is highly vulnerable to injury resulting in subsequent cognitive and motor disabilities. Our goal was to show that there are microstructural abnormalities in regions of the brain separate from the focal necroses in non-cystic periventricular leukomalacia. A diverse cohort of neonates was scanned at term equivalent age using DTI. We found that there is microstructural injury in white matter regions both proximal and distant from necrotic foci. 14:30 4380. Snapshot Inversion Recovery (SNAPIR): A Robust, Optimised T1-Weighted Fetal Brain MRI Protocol for Improved Anatomy Delineation Christina Malamateniou 1 , Amy McGuinness 1 , Prachi Patkee 1 , Joanna M. Allsop 1 , Mary A. Rutherford 1 , Jo V. Hajnal 1 1 Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, United Kingdom Image quality of standard gradient echo T1-weighted fetal brain MRI acquisitions is poor because of artefacts relating to fetal and maternal motion. The Snapshot Inversion Recovery (SNAPIR) sequence, an optimised T1-weighted protocol using single shot techniques, offers a potential robust alternative to standard T1-weighted methods. Qualitative analysis showed that significantly increased visualisation of the fetal brain anatomy was achieved with SNAPIR in 24 out of 32 anatomical structures studied, compared to the reference protocol. Additionally, quantitative analysis showed that SNAPIR presented with significantly increased contrast ratios between grey and white matter in the upper (p=0.01) and lower cerebrum (p=0.0001). 15:00 4381. Construction of a Dynamic 4D Probabilistic Atlas for the Developing Brain Maria Murgasova 1 , Latha Srinivasan 2 , Ioannis S. Gousias 2 , Paul Aljabar 1 , Joseph V. Hajnal 2 , A David Edwards 2 , Daniel Rueckert 1 1 Computing, Imperial College London, London, United Kingdom; 2 Imaging Sciences, Imperial College London Probabilistic atlases have been established in the literature as a standard tool for enhancing the intensity-based classification of brain MRI. The rapidly growing neonatal brain requires an age-specific spatial probabilistic atlas to guide the segmentation process. In this paper we describe a method for dynamically creating a probabilistic atlas for any chosen stage of neonatal brain development. We present an atlas created from the segmentations of 153 subjects providing prior tissue probability maps for six structures - cortex, white matter, subcortical gray matter, brainstem and cerebellum, for ages of 29 to 44 weeks of gestation. Wednesday 13:30-15:30 Computer 80 13:30 4382. Early Neonatal Brain Development: Correlation Between DTI and MRS Lynn Michelle Anderson 1 , Linda Chang 1 , Steven Buchthal 1 , Brian Keating 1 , Christine Cloak 1 , Thomas Ernst 1 1 Department of Medicine, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hi, United States Normal infant brain development was evaluated using both DTI and MRS. Apparent diffusion (ADC) and fractional anisotropy (FA) were correlated to brain metabolites within the same MRS voxel in 5 brain regions. With increasing postconceptional age, increases in FA and decreases in ADC were associated with increases in NA, in the frontal white matter, which reflect more coherent fiber organization and axonal growth. Similar age-related changes in DTI measures in the CST were associated with decreased MI which
suggests myelination or a reduction in radial glia. Decreased tCr and CHO in the FGM combined with decreased ADC suggest cellular pruning. 14:00 4383. More Than Meets the Eye: Age and Pathology-Related MTR Changes in Very Preterm Brains Andrew David Chung 1 , Revital Nossin-Manor 1,2 , Hilary E. A. Whyte 2,3 , Margot J. Taylor 1,2 , Manohar M. Shroff 1 , John G. Sled 4,5 1 Diagnostic Imaging, Hospital for Sick Children, Toronto, ON, Canada; 2 Neurosciences & Mental Health, Research Institute, Hospital for Sick Children, Toronto, ON, Canada; 3 Neonatology, Hospital for Sick Children, Toronto, ON, Canada; 4 Physiology Experimental Medicine, Research Institute, Hospital for Sick Children, Toronto, ON, Canada; 5 Medical Biophysics, University of Toronto, Toronto, ON, Canada Our study compared MTR values of the basal ganglia (BG), thalami, and pons in the very preterm (
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ELECTRONIC POSTER Cartilage Hall B
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15:00 3182. Comparison of Short Ech
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to unity. Conversely, in trabecular
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determination of perfusion and perm
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unique ability of UTE MRI to direct
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throughout the maturation process,
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lipoatrophy with decreased of the l
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hyperpolarized for use as a metabol
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use of short and high bandwidth adi
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Increasing spatial resolution is ad
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Spectroscopic Localization & Imagin
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total scan time and remove the spac
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BOLD activation within parenchymal
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the brain edge. Upon detrending thi
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healthy controls using empathy for
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activates superior colliculus and l
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Myocardial Function Human & Experim
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Non-Cartesian k-space trajectories
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14:30 3601. Analysis of Cardio-Resp
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depending on its linear or centric
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3Tesla using a 32 channel cardiac c
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States; 5 Chemistry & Chemical Engi
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similar set of fully sampled data.
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demonstrated 35% improvement in blo
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15:00 3679. Toward a Novel Implanta
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and 13 patients, including peak and
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facilitate in the robust and reprod
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accurate quantification. The -goal
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and then auto-transplanted back to
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14:30 3755. The Use of Cellular MRI
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sampling patterns which are tailore
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with potential for improving diagno
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Receive Arrays Hall B Monday 14:00-
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the past and thus yields more reali
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challenges for its simultaneous com
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experimental results showed the bes
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and a relaxed fixed point iteration
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existing parallel imaging and parti
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Arterial Spin Labeling: Methods Hal
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using both methods but the differen
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estimates. Differences in delays an
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14:30 4134. Optimal Ultrasonic Focu
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Metabolism Liver & Other II Hall B
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Body Diffusion Hall B Monday 14:00-
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prevention. In this study we have e
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Tuesday 13:30-15:30 Computer 105 13
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present initial results in terms of
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of Cardiology, Munich University Ho
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appropriately describes the uptake
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tumour. A significant reduction in
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14:30 4838. Detection and Improveme
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Our results indicate that the propo
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egularizing terms that may affect t
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times due to the need of additional
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proposed homotopic L0 minimization
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1 Imaging Division, UMC utrecht, Ut
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frequency k-space data are processe
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cylinders trajectory and have imple
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still requires scan durations not a
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perform the AC of the SPECT data. T
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egularization parameter is adapted
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IDEAL knee MRI data is proposed. Va
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