ELECTRONIC POSTER - ismrm

Tuesday 13:30-15:30 Computer 36
13:30 3684. Carotid Plaque Imaging with an Eight-Channel Transmit/Receive RF Array at 7
Tesla: First Results in Patients with Atherosclerosis.
Tobias Breyer 1,2 , Oliver Kraff 1,2 , Stefan Maderwald 1,2 , Andreas Bitz 1,2 , Stephan Orzada 1,2 ,
Mark E. Ladd 1,2 , Elke R. Gizewski 1,2 , Harald H. Quick, 23
1 Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen,
Nordrhein-Westfalen, Germany; 2 Erwin L. Hahn Institute for Magnetic Resonance Imaging, University of
Duisburg-Essen, Essen, Germany; 3 Institute of Medical Physics, Friedrich-Alexander-University Erlangen-
Nürnberg, Erlangen, Germany
Atherosclerosis is one leading cause of morbidity. In this study we implemented and adapted a plaque imaging protocol from 1.5 to 7
Tesla with use of a custom-built eight-channel transmit/receive RF array for the first time in human patients with hemodynamically
relevant atherosclerosis. This approach allows for MR angiographic imaging without administration of gadolinium contrast
comparable to contrast-enhanced MR angiography at lower field strengths. Plaque imaging at 7 Tesla requires different sequences
compared to lower field strengths but allows a qualitatively comparable depiction of different intraplaque components, calcifications,
vessel wall thickness and the luminal surface compared to lower field strenghts.
14:00 3685. Targeted Multi-Contrast Vessel Wall Imaging of Bilateral Peripheral Artery
Disease
Niranjan Balu 1 , Jinnan Wang 2 , Xihai Zhao 1 , Thomas Hatsukami 1 , Chun Yuan 1
1 University of Washington, Seattle, WA, United States; 2 Philips Research North America
Assessment of vessel wall involvement in peripheral arteries and veins can significantly improve the management of peripheral
arterial disease (PAD) and deep vein thrombosis (DVT). The diffuse and bilateral disease in PAD requires bilateral large coverage.
Assessment of lesion composition additionally requires multi-contrast imaging. However scan times for current black-blood MRI
techniques can be prohibitively long. To address this issue we demonstrate a targeted high resolution multi-contrast imaging protocol
combining bilateral isotropic large coverage 3D black-blood MRI for screening and optimized high-resolution 2D black-blood MRI.
One case of DVT was identified out of six subjects scanned and characterized by multi-contrast imaging within a 30 minute scan time.
14:30 3686. Sex Differences of High-Risk Carotid Atherosclerotic Plaque in Asymptomatic
Patients with Varying Levels of Stenosis -In Vivo 3.0T MRI Study
Hideki Ota 1,2 , Mathew J. Reeves 3 , David C. Zhu 2 , Arshad Majid 4 , Alonso Collar 5 , Nikunj
Chauhan, Chun Yuan 6 , J.Kevin DeMarco 2
1 Diagnostic Radiology, Tohoku University, Sendai, Miyagi, Japan; 2 Radiology, Michigan State University, East
Lansing, MI, United States; 3 Epidemiology, Michigan State University, East Lansing, MI, United States;
4 Neurology & Ophthalmology, Michigan State University, East Lansing, MI, United States; 5 Ingham
Cardiothoracic & Vascular Surgeons, Lansing, MI, United States; 6 Radiology, University of Washington,
Seattle, WA, United States
The purpose of this study was to evaluate prevalence of complicated, high-risk carotid plaque characteristics in both men and women
with a broad range of carotid artery stenosis. A total of 230 arteries (51% men) in 132 patients having 0-99% carotid stenosis were
included for the analysis. After adjusting for baseline demographic characteristics as possible confounders, presence of complicated
AHA VI plaque, lipid-rich/necrotic core, intraplaque hemorrhage were significantly more common in men than women. Increasing
MRA stenosis was also associated with these high-risk plaque features. The present results indicate that the development of
atherosclerosis appears different between men and women.
15:00 3687. In Vivo Detection of Vulnerable Atherosclerotic Plaque by Magnetic Resonance
Imaging
alkystis phinikaridou 1 , Frederick L. Ruberg, Hallock J. Kevin, Ye Qiao 2 , Ning Hua, Jason
Viereck, James A. Hamilton
1 physiology and biophysics, boston university, boston, ma, United States; 2 Johns Hopkins
We used a rabbit model of controlled atherothrombosis to test whether in vivo MRI can distinguish between plaques that disrupt after
pharmacological triggering (vulnerable) and those that do not (stable). In vivo MRI revealed that stable and vulnerable plaques had
similar percent of stenosis, but vulnerable plaques more frequently showed: (1) positive remodeling, in which the plaque remains
hidden within the vessel wall; and (2) enhanced gadolinium uptake associated with histological features of neovascularization,
inflammation, and necrosis. These findings suggest that in vivo MRI may be used for localization of plaques that are prone to
disruption prior to acute events.