ELECTRONIC POSTER - ismrm

3Tesla using a 32 channel cardiac coil, which allow 4-fold acceleration factor. Good image quality and CNR was obtained in three
subjects anticipating a clinical validation of this pulse sequence
14:30 3630. Myocardial T1 During Multiple Bolus Injections
Christian Stehning 1 , Timothy Lockie 2 , Eike Nagel 3 , Masaki Ishida 3 , Sven Plein 3
1 Philips Research Europe, Hamburg, Germany; 2 Cardiovascular Division, King's College, London, United
Kingdom; 3 Division of Imaging Sciences, King's College, London, United Kingdom
MR first pass perfusion imaging via the dynamic enhancement after intravenous contrast injection has become a valuable clinical tool
for the assessment of myocardial perfusion. The aim of the present study was to investigate whether such a saturation effect of
myocardial T1 has to be taken into account in MR-based perfusion studies involving multiple injections of Gd-DTPA.
15:00 3631. Magnetic Resonance Quantification of Myocardial Perfusion with a Minimally
Constrained Deconvolution Model
Omar El-Sherif 1,2 , Robert Z. Stodilka 1,2 , Nathan A. Pack 3,4 , Edward VR Dibella 3,4 , James
A. White 5 , Robert Terry Thompson 1,2 , Frank S. Prato 1,2
1 Imaging, Lawson Health Research Institute, London, Ontario, Canada; 2 Medical Biophysics, University of
Western Ontario, London, Ontario, Canada; 3 Department of Bioengineering, University of Utah, Salt Lake City,
UT, United States; 4 Radiology, Utah Center for Advanced Imaging Research, Salt Lake City, UT, United
States; 5 Cardiology, London Health Sciences Centre, London, Ontario, Canada
We introduce a novel minimally constrained myocardial perfusion analysis technique. The technique has been implemented on
dynamic contrast enhanced magnetic resonance images, obtained from 10 patients with hypertrophic cardiomyopathy. Regional
myocardial perfusion estimates were directly compared to both the Fermi perfusion model and a 2 compartment perfusion model. The
results indicate that there is discrepancy between Fermi and 2 compartment models during stress exams. However our technique
correlates well with the Fermi model during both stress and rest exams.
Myocardial Visibility: Experimental Models
Hall B Monday 14:00-16:00 Computer 33
14:00 3632. Imaging of Inflammation Using VSOP and T2* Mapping in a Mouse Model of
Myocardial Infarction
Andrea Protti 1 , Alexander Sirker 1 , Xuebin Dong 1 , Marcelo Andia 2 , Ajay M. Shah 1 , Rene
Botnar 2
1 Cardiovascular Division, King’s College London BHF Centre of Excellence, London, United Kingdom;
2 Division of Imaging Sciences, King’s College London BHF Centre of Excellence, London, United Kingdom
In this work, we sought to investigate the merits of a very small superparamagnetic iron oxide particle (VSOP) for direct imaging of
inflammation in a mouse model of MI and to quantify T2* using multi echo gradient echo images. The combined use of a very small
iron-oxide particle, VSOP, and the use of short to long TE acquisition to generate T2* mapping allowed the quantitative assessment of
VSOP uptake in the infarct zone.
14:30 3633. Studying Indirect Ca 2+ Alterations Following Myocardial Infarction in a Murine
Model Using T 1 -Mapping Manganese-Enhanced MRI
Benjamin Waghorn 1,2 , Jimei Liu 1 , Nathan Yanasak 1 , Tom C.-C. Hu 1,2
1 Department of Radiology, Medical College of Georgia, Augusta, GA, United States; 2 Nuclear and Radiological
Engineering and Medical Physics Programs, Georgia Institute of Technology, Atlanta, GA, United States
Intracellular calcium (Ca 2+ ) overloading that occurs during myocardial ischemia-reperfusion is known to exacerbate injuries. This
study demonstrates the use of cardiac T 1 -mapping manganese-enhanced MRI for identifying and quantifying regional differences in
tissue Mn 2+ , and therfore inferred Ca 2+ , handling that occur after a myocardial infarction (MI) in the murine model. Regional
alterations in Mn 2+ efflux were detected, suggesting changes in NCX activity and altered Mn 2+ content in ischemic tissue, consistent
with changes in Ca 2+ handling post-MI. This technique could potentially be developed to provide and indirect in vivo assessment of
Ca 2+ handling alterations.
15:00 3634. MR Tagging on Healthy and MI Mice Model, an EF Vs Strain Study
Andrea Protti 1 , Alexander Sirker 1 , Ajay M. Shah 1 , Rene Botnar 2
1 Cardiovascular Division, King’s College London BHF Centre of Excellence, London, United Kingdom;
2 Division of Imaging Sciences, King’s College London BHF Centre of Excellence, London, United Kingdom
In this study we sought to investigate radial and circumferential strain in a mouse model of myocardial infarction (MI) 3 weeks post
left anterior diagonal (LAD) coronary artery ligation and healthy control mice using 2D SPAMM technique. Strain was correlated
with ejection fraction (EF) and left ventricular (LV) infarct size. MR tagging analysis provided important information on LV regional
contraction and allowed assessment of wall motion alterations in MI mice.