ELECTRONIC POSTER - ismrm

Wednesday 13:30-15:30 Computer 92
13:30 4574. Evaluation of a Non-Enhanced MRI Protocol Compared to Gadolinium-Enhanced
MRI for Hepatocellular Carcinoma
Andrew Dean Hardie 1
1 Radiology, Medical University of South Carolina, Charleston, SC, United States
MRI is accurate for identifying hepatocellular carcinoma however gadolinium chelates are contraindicated in patients with severe
renal dysfunction due to the risk of Nephrogenic Systemic Fibrosis. There is a need to develop clinically usefull non-contrast MRI
techniques to image these patients. Diffusion-weighted imaging and T2* weighted imaging offer the ability to identify tumors in
cirrhotic patients with an accuracy similar to gadolinium MRI.
14:00 4575. Evaluation of a New Multi-Modality Visualization Tool for Investigation of Hepatic
Metastases from Colorectal Cancer
Laurent Milot 1 , Kayan Ma 2 , Erin Efford 1 , Gal Sela 2 , Carolyn Maloney 1 , Susan Crisp 1 ,
Natalie Coburn 3 , Masoom Haider 1 , Cameron Piron 2 , Calvin Law 3 , Don Plewes 4
1 Department of Medical Imaging, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; 2 Sentinelle
Medical Inc, Toronto, Ontario, Canada; 3 Department of Surgical Oncology, Sunnybrook Health Sciences
Centre, Toronto, Ontario, Canada; 4 Department of Imaging Research, Sunnybrook Health Sciences Centre,
Toronto, Ontario, Canada
Ultrasound and MRI provide complimentary information useful in pre-operative planning for surgical resection of hepatic metastases
from colorectal cancer. This study investigates the value of real-time co-registration of preoperative MRI and ultrasound images to
determine if this method improves the ability to localize suspicious targets under ultrasound, using MRI as a gold standard. Coregistered
MRI/ultrasound imaging yielded a significant increase in the number of targets successfully localized compared to
ultrasound examination alone. Co-registered imaging was particularly effective in localizing small lesions (less than 5 mm) which
were difficult to identify under conventional ultrasound examination.
14:30 4576. Pharmacokinetics and Safety of Gadobenate Dimeglumine in Patients from 2 to 5
Years of Age
Gianpaolo Pirovano 1 , Mieczyslaw Pasowicz 2 , Miles A. Kirchin 3 , Ningyan Shen 4 , John R.
Parker 5 , Alberto Spinazzi 1
1 Medical Affairs, Bracco Diagnostics Inc., Princeton, NJ, United States; 2 Radiology, John Paul II Hospital,
Kracow, Poland; 3 Medical Communications, Bracco Imaging, Milan, Italy; 4 Biometrics, Bracco Diagnostics
Inc., Princeton, NJ, United States; 5 Medical Communications, Bracco Diagnostics Inc., Princeton, NJ, United
States
15 subjects aged 2-5 years were enrolled in a pharmacokinetic study and received 0.1 mmol/kg bw gadobenate dimeglumine.
Pharmacokinetic parameters were calculated from the blood Gd concentration-time data using compartmental and noncompartmental
techniques. At 6 hours after gadobenate dimeglumine administration, all subjects¡¦ residual Gd in blood was close to 1.0 ƒÝg/mL,
indicating that Gd was successfully cleared from the blood. No differences in whole blood or urinary pharmacokinetic parameters
were observed between pediatric subjects 2 to 5 years when compared to adult subjects studied in previously.
15:00 4577. MRI of Infiltrative HCC- Characterization of Imaging Features in Association with
Clinical Presentation
Bobby Kalb 1 , Douglas Vander Kooi 2 , Daniel Karolyi 1 , Bhavika Patel 1 , Khalil Salman 1 ,
Diego R. Martin 1
1 Radiology, Emory University, Atlanta, GA, United States; 2 Radiology, Langley Airforce Base, Hampton, VA,
United States
Infiltrative-type of HCC (I-HCC) is an incurable, less common growth pattern of HCC that may mimic fulminant CLD. Distinction of
I-HCC on MRI is critical for optimal management and to avoid inadvertent transplantation of incurable disease, however imaging
features may be atypical with poor visibility of tumor extent on postcontrast images. We have categorized MR imaging and pathologic
features of I-HCC, and found tumor conspicuity to be most pronounced on T2-weighted images, with portal venous tumor thrombus
present in all cases. These findings are important to help improved clinical application of MRI in the setting of CLD.
Thursday 13:30-15:30 Computer 92
13:30 4578. Computational Analysis of Flow in the Portal Vein of Normal Subjects and Patients
Using MRI and CFD
Stephanie M. George 1 , Diego R. Martin 2 , Don P. Giddens 1
1 Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory
University, Atlanta, GA, United States; 2 Department of Radiology, Emory University School of Medicine,
Atlanta, GA, United States
With the incidence of chronic liver disease (CLD) increasing the need for improved diagnostic measurements has increased. Magnetic
resonance imaging (MRI) and phase-contrast MR offer noninvasive techniques which provide both high quality anatomical and
hemodynamic data. The use of these data coupled with computational fluid dynamics (CFD) to provide detailed flow field