ELECTRONIC POSTER - ismrm

14:30 4532. 1H MRS of Cortical and Subcortical Structures in Mild and Severe Neonatal
Hypoxic-Ischemic Cerebral Injuries
Kevin C. Chan 1,2 , Ed X. Wu 1,2
1 Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR,
China; 2 Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR,
China
This study employed in vivo 1H MRS to understand the metabolic alterations in cortical and subcortical structures during the recovery
period upon mild and severe hypoxic-ischemic (HI) injuries to the neonatal rat brains. Relative to the Cr peak, results showed a further
increase in Cho, Glu and Lac in the left cortex of severe HI group than mild HI group at 3 days after HI injury at postnatal day 7.
These values then decreased slightly at 7 days after surgery in both HI groups. Tau also increased on both sides of the cortex at Day 3
and then drop at Day 7 for both HI groups. In the left thalamus of the severe HI group, NAA appeared to decrease transiently at Day 3
and normalize at Day 7, whereas Cho, Glu, Lac and Tau levels apparently peaked at Day 3. The results of this study may help to
investigate potential therapies and the recovery mechanisms upon different severity of neonatal HI insults.
15:00 4533. Early Metabolic Changes Following Focal Traumatic Brain Injury in Rats
Measured Using 1 H MRS
Su Xu 1,2 , Steve Roys, 23 , Jennifer Racz 4 , Da Shi 1,2 , Jiachen Zhuo 1,2 , Rao Gullapalli, 23 ,
Gary Fiskum 1,4
1 Core for Translational Research in Imaging @ Maryland (C-TRIM), University of Maryland School of
Medicine, Baltimore, MD, United States; 2 Diagnostic Radiology and Nuclear Medicine, University of Maryland
School of Medicine, Baltimore, MD, United States; 3 Core for Translational Research in Imaging @ Maryland
(C-TRIM), University of Maryland School of Medicine, Baltimore, MD, United States; 4 Anesthesiology and the
Center for Shock Trauma and Anesthesiology Research, University of Maryland School of Medicine,
Baltimore, MD, United States
Traumatic brain injury is characterized by acute physiological changes that may play a significant role in the final outcome resulting
from the injury. Experimental models of TBI provide a useful tool for understanding the early cerebral metabolic changes induced by
the damage. In this study, we investigate the early post-traumatic changes in neuro-metabolites in the rat brain following controlled
cortical impact injury using in vivo 1 H MRS at 7 Tesla. Significant changes in N-acetylaspartate, glutamate and choline were observed
within the first 3 hours after injury in the pericontusional area suggesting a possible temporal window for therapeutic intervention.
Breast MR: Diffusion, Spectra & High Field
Hall B Monday 14:00-16:00 Computer 90
14:00 4534. Diffusion MR Breast Imaging: Correlation of ADC Values to the Prognostic Factors
Sunitha B. Thakur 1 , David D. Dershaw 2 , Dilip Giri 3 , Junting Zheng 4 , Chaya Moskowitz,
Jessica Ferrara 2 , Jason A. Koutcher 1 , Elizabeth A. Morris 2
1 Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States; 2 Radiology,
Memorial Sloan Kettering Cancer Center, New York, NY, United States; 3 Pathology, Memorial Sloan Kettering
Cancer Center, New York, NY, United States; 4 Epidemiology-Biostatistics, Memorial Sloan Kettering Cancer
Center, New York, NY, United States
Treatment decisions and determination of breast cancer prognosis have traditionally been based on pathologic parameters such as
tumorsize and axillary-nodal status, tumor-grade, and the results of tumor markers mainly ER/PR and HER-2/neu. Here we present the
clinical usefulness of Diffusion-weighted MRI and measurement of apparent diffusion coefficients (ADCs) to correlate traditional
markers such as histology and molecular markers such as ER, PR and HER-2. Mean tumor size is significantly higher in patients with
positive lymph nodes. Although ADC values represent a valuable biomarker for detecting malignant lesions, the ADC cannot be a
prognostic indicator for patients with breast cancer.
14:30 4535. Post Lumpectomy MRI: Using Diffusion Weighted Imaging (DWI) to Distinguish
Benign from Malignant Tissues
Frederick Kelcz 1 , Kendra S. Hain 1
1 Radiology, University of Wisconsin, Madison, WI, United States
We reviewed diffusion imaging results in post lumpectomy patients and preliminary results show a consisent ADC value in the benign
range, despite persistent, occasionly concerning enhancement. DWI may be of great value in ruling in benignancy when
differentiating enhancing scar from malignancy.