ELECTRONIC POSTER - ismrm

MRS - Body Applications
Hall B Monday 14:00-16:00 Computer 102
14:00 4725.
1 H-MRS Links Adipose Tissue Fat Composition to Liver Fat Content in Men with
Metabolic Syndrome
Jesper Lundbom 1 , Antti Hakkarainen 1 , Sanni Söderlund 2 , Nina Lundbom 1 , Marja-Riitta
Taskinen 2
1 HUS Medical Imaging Centre, University of Helsinki, Helsinki, Finland; 2 Department of Medicine, University
of Helsinki
We used 1H-MRS to study adipose tissue fat composition and liver fat content in men with the metabolic syndrome. Adipose tissue
methylene/methyl, an index of saturated fats, correlated negatively with liver fat content.
14:30 4726. In-Vivo Determination of the Full 1 H MR Spectrum of Liver Fat
Gavin Hamilton 1 , Michael S. Middleton 1 , Takeshi Yokoo 1 , Mark Bydder 1 , Irene W.
Mwangi 1 , Michael E. Schroeder 1 , Claude B. Sirlin 1
1 Department of Radiology, University of California, San Diego, San Diego, CA, United States
Accurate proton ( 1 H) MRS fat quantification of liver fat requires determination of signal from fat peaks that are near or under the
water peak. A theoretical triglyceride model was developed to characterize the liver fat spectrum, using number of -CH=CH- and -
CH=CH-CH 2 -CH=CH- bonds, and average fatty acid chain length. In vivo, the relative areas of the different fat peaks are strongly
correlated suggesting the fat profile is uniform regardless of the level of fat deposition in the liver. The model gives that 8.6% of the
total liver fat underlies the water peak.
15:00 4727. Comparison of Liver Steatosis Quantification by MRS at 4.7 T and Histology on
Ob/ob and Db/db Mice
Fanny Noury 1,2 , Alain Fautrel 3,4 , Eric Hitti 1,2 , Pascale Bellaud 3 , Hervé Saint-Jalmes 1,2 ,
Bernard Fromenty 4 , Pierre-Antoine Eliat 2
1 LTSI - INSERM U642 - Université Rennes 1, Rennes, France; 2 PRISM - IFR 140 BiogenOuest - Université
Rennes 1, Rennes, France; 3 Plate-forme d’Histopathologie - IFR 140 BiogenOuest - Université Rennes 1,
Rennes, France; 4 FMC - INSERM U991 - IFR 140 - Université Rennes 1, Rennes, France
Murine models of obesity such as ob/ob (leptin deficient) and db/db (leptin receptor deficient) mice are extensively used in different
scientific fields including pharmacology and toxicology. Besides increased body fatness, hyperlipidemia and insulin resistance these
mice develop moderate (db/db) or massive (ob/ob) steatosis. In some studies a longitudinal follow-up of steatosis may be warranted,
to assess the beneficial (or deleterious) effects of chronic drug administration. In this preliminary study, db/db and ob/ob mice were
used to determine whether magnetic resonance spectroscopy could be a reliable non-invasive method to evaluate fatty liver, using
statistical comparison with histological results.
15:30 4728. Validation of 1 H Magnetic Resonance Spectroscopy ( 1 H-MRS) for Quantification of
Hepatic Triglyceride Content
Estee Fleischman 1 , Lauren Dutcher 1 , David Thomasson 2 , Adeline Louie 2 , Haresh Mani 3 ,
David Kleiner 3 , Caryn Morse 1 , Colleen Hadigan 1
1 National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United
States; 2 Diagnostic Radiology Department, National Institutes of Health, Bethesda, MD, United States;
3 National Cancer Institute, National Institutes of Health, Bethesda, MD, United States
There is growing interest in the application of 1H-MRS as a non-invasive approach to quantify hepatic triglyceride. This study was
designed to establish the ability of 1H-MRS to accurately assess hepatic fat compared to histological scoring. Fifty subjects completed
1H-MRS of the liver within 30 days of diagnostic biopsy. The mean hepatic triglyceride content by 1H-MRS for each histologic
grade was 9%, 23%, 40% and 56%, respectively. The correlation between the two methods was r=0.88, p