ELECTRONIC POSTER - ismrm

14:00 4479. Voxel-Based Analysis of High- And Standard B-Value Diffusion Weighted Imaging
and Voxel-Based Morphometry in Inherited Prion Disease
Enrico De Vita 1,2 , Harpreet Hyare 1,3 , Gerard Ridgway 4 , Simon Mead 3 , Peter Rudge 3 ,
John C. Collinge 3 , Tarek A. Yousry 1,2 , John S. Thornton 1,2
1 Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United
Kingdom; 2 Academic Neuroradiological Unit, Institute of Neurology, University College London, London,
United Kingdom; 3 MRC Prion Unit, Institute of Neurology, University College London, London, United
Kingdom; 4 Dementia Research Centre. Dept. of Neurodegenerative Diseases, Institute of Neurology, University
College London, London, United Kingdom
Diffusion weighted imaging (DWI) is the most sensitive MRI sequence for diagnosis in human prion disease. High-b-value
(b~3000s/mm2; b3k) DWI was shown to be more sensitive to pathology in sporadic Creutzfeldt-Jacob disease than standard DWI
(b~1000s/mm2; b1k). Most previous prion disease studies used region of interest analyses. We employed operator-independent voxelbased
morphometry and voxel-based analysis (VBA) of DWI (b1k and b3k) to characterise structural parenchymal changes in
inherited prion disease (iPD) patients. In this cohort, DWI-VBA resulted more sensitive than VBM, potentially indicating
microstructural changes occurring before grey matter atrophy becomes detectable; b1k acquisitions resulted relatively more sensitive
vs b3k.
14:30 4480. Mapping the Distribution of Local Cross-Term Gradients Using DTI in Patients
with Alzheimer¡¯s Disease
Geon-Ho Jahng 1 , Songfan Xu 2 , Chang-Woo Ryu 1 , Dal-Mo Yang 1 , Dong-Wook Sung 3 ,
Dong Ho Lee 3 , Seungjoon Park 4
1 Radiology, East West Neo Medical Center, Kyung Hee University, Seoul, Korea, Republic of; 2 Biomedical
Science, Graduate School of Medicine, Kyung Hee University, Seoul, Korea, Republic of; 3 Radiology, KHU
Hospital, Kyung Hee University, Seoul, Korea, Republic of; 4 Pharmacology and and Biomedical Science,
School of Medicine, Kyung Hee University, Seoul, Korea, Republic of
To map the strength of a local cross-term gradient among diffusion, imaging, and background gradients in groups of AD, MCI, and
cognitive normal (CN), two DT-MRI sets with positive and negative polarities of diffusion-sensitizing gradients were obtained in 15
AD and18 MCI patients and 16 CN controls with four b-values. The cross-term b-value (bc) maps for each subject group were
calculated. The bc differs locally between AD patient and MCI or CN subjects, but not between MCI and controls and we may obtain
the strength of a local background gradient using DTI data.
15:00 4481. Lateralisation of Perisylvian Pathways with Age in Asperger’s Syndrome – a Cross-
Sectional DTI Study
Sanja Budisavljevic 1 , Flavio Dell'Acqua, Stephanie Forkel, Michel Thiebaut de Schotten,
Marco Catani
1 Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College, London,
United Kingdom
Using DT-MRI tractography we investigated lateralisation of perisylvian pathways with age in Asperger’s Syndrome. We observed
that the indirect pathway of the arcuate fasciculus shows abnormal development with age in people with Asperger’s syndrome
compared to controls. This suggests that abnormalities in white matter development may be a key feature of autism spectrum disorders
and may explain impairments in language and communication.
Thursday 13:30-15:30 Computer 86
13:30 4482. Longitudinal Changes of DTI Parameters During Acute and Sub-Acute Phase
Following Mild Traumatic Brain Injury Using Tract-Based Spatial Statistics Analysis: The
Preliminary Results
Tong Zhu 1 , Jeffrey Bazarian 2 , Jianhui Zhong 1
1 Imaging Sciences, University of Rochester, Rochester, NY, United States; 2 Emergency Medicine, University of
Rochester, Rochester, NY, United States
DTI studies of both human mTBI subjects and animal TBI models have shown different alteration patterns of tensor derived
parameters, such as fractional anisotropy (FA), axial and radial diffusivity, with the accompanying neurological impairments
following initial concussions. In this study, we performed a prospective longitudinal study of mTBI patients with three DTI scans for
each subject to characterize the acute (within 24 hrs), late acute (1 week) and sub-acute (1 month) phase following mTBI. The tractbased
spatial statistics (TBSS) was performed to achieve voxelwise statistical comparisons of longitudinal changes of DTI parameters
for quantification of white matter micro-structural alterations. In 13 mTBI patients and 21 healthy controls analyzed so far we
observed decreased FA and increased radial diffusivity in several major white matter tracts such as the genu corpus callosum, the
anterior corona radiata and the internal capsule, although our findings are only approaching significance (p