ELECTRONIC POSTER - ismrm

15:00 4369. Brain Morphometry Correlates of Pharmacoresistancy in Schizophrenia
Mario Quarantelli 1 , Olga Palladino 2 , Anna Prinster 1,3 , Vittorio Schiavone 2 , Barbara
Carotenuto 4 , Arturo Brunetti 4 , Gianluca Ventrella 2 , Angela Marsili 1 , Andrea De
Bartolomeis 2 , Marco Salvatore 4
1 Biostructure and Bioimaging Institute, National Research Council, Naples, Italy; 2 Institute of Psychiatry,
University “Federico II”, Naples, Italy; 3 “S.D.N.” Foundation, Naples, Italy; 4 Department of Biomorphological
and Functional Sciences, University “Federico II”, Naples, Italy
We assessed structural cerebral differences between 16 normal volunteers (NV), 16 Responder (R-SC), and 19 Non-Responder (NR-
SC) schizophrenia patients. Segmented T1-weighted volumes were analyzed voxel-wise to assess local differences in gray matter
volume between the three groups, using permutation tests implemented in the CamBA software. Main clusters of significant GM
differences among the three groups emerged in bilateral frontal cortices, right insula and right medial temporal lobe, differences being
mainly due to reduced GM volumes in NR-SC, as compared to both NV and R-SC, suggesting that differences between NV an SC
may be mainly driven by NR-SC patients.
Thursday 13:30-15:30 Computer 79
13:30 4370. Increased Anterior Cingulate GABA Level Following Electroconvulsive Therapy in
Patients with Major Depressive Episodes
Pallab Bhattacharyya 1 , Erik Beall 1 , Mark Lowe 1 , Micheal Phillips 1 , David Muzina 1
1 Cleveland Clinic, Cleveland, OH, United States
Gamma amino butyric acid (GABA) level in anterior cingulate is known to be reduced in depression patients. Electroconvulsive
therapy (ECT) is a commonly used treatment for major depressive episodes (MDE). Using 1 H spectroscopy we have measured anterior
cingulate GABA level 2 weeks before and 1-2 weeks after ECT treatment in MDE patients. Our preliminary data show an increase in
anterior cingulate GABA level following ECT in MDE patients.
14:00 4371. Cingulate Cortex Functional Connectivity Increase Predicts Relapse of Major
Depression.
Naranjargal Dashdorj 1 , Neil L. Nixon 2 , G Worwood 2 , M Liotti 2 , E Georgiadi 2 , D P.
Auer 1 , P F. Liddle 2
1 Academic Radiology, University of Nottingham, Nottingham, United Kingdom; 2 Division of Psychiatry,
University of Nottingham, Nottingham, United Kingdom
Functional imaging studies suggest alterations in cortico-limbic circuit connectivity in depression. Moreover, these functional
connectivity (fc) changes were found to correlate with symptom severity and normalised upon antidepressant treatment. The direction
of these fc changes is however debated with one group showing increased default network connectivity and another showing
decreased cortico-limbic connectivity. Nonetheless, more studies implicate cingulate gyrus as a focus of dysfunction. In this study, we
compared fc of the rostral anterior cingulate between patients with history of remitted recurrent depression and healthy controls.
14:30 4372. Regional Gray Matter Changes in Major Depressive Disorder: An Optimized Voxel-
Based Morphometry Study
Zhiyun Jia 1 , Tijiang Zhang 1 , Qizhu Wu 1 , Junran Zhang 1 , Su Lu 1 , Xiaoqi Huang 1 ,
Weihong Kuang 2 , Qiyong Gong 1
1 Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University,
Chengdu, Sichuan provice, China; 2 Department of Psychiatry, West China Hospital of Sichuan University
High resolution 3-dimensional T1-weighted (T1W) images were acquired using a 3.0T MR scanner in fifty two patients experiencing
major depression (MDD) and fifty two normal controls. Using voxel based morphometry (VBM), we demonstrated that MDD patients
have higher volume and density of grey matter in multiple brain areas than controls, especially in bilateral thalamus. This is consistent
with a previous postmortem study which demonstrated increased neuronal number in the thalamus of patients with depression relative
to the nonpsychiatric comparison subjects. Further study should reveal this change in thalamus using multiple methods.
15:00 4373. Thickness Profile Generation for the Corpus Callosum Using Laplace's Equation
Christopher Leslie Adamson 1 , Amanda Wood 1,2 , Jian Chen 1 , Sarah Barton 1 , David
Reutens 3 , Mark Walterfang 4,5
1 Developmental and Functional Brain Imaging, Murdoch Childrens Research Institute, Melbourne, VIC,
Australia; 2 Department of Medicine, Southern Clinical School, Monash University, Melbourne, VIC, Australia;
3 Centre for Advanced Imaging, University of Queensland, Brisbane, QLD, Australia; 4 Neuropsychiatry Unit,
Royal Melbourne Hospital, Melbourne, VIC, Australia; 5 Melbourne Neuropsychiatry Centre, University of
Melbourne, Melbourne, VIC, Australia
We present a method to generate thickness profiles of the corpus callosum from midsagittal slices of MR images. The method is
mostly automated, robust and computationally efficient. We utilise the method to reveal morphological changes of the corpus
callosum at different stages of schizophrenia.