ELECTRONIC POSTER - ismrm

14:30 4279. Radiation Toxicity to the Normal Brain Detected by Echoplanar Spectroscopic
Imaging in Patients with Brain Metastases Treated with Whole Brain Radiation Therapy
Sanjeev Chawla 1 , Sumei Wang 1 , Sulaiman Sheriff 2 , Lisa Desiderio 1 , Alexander Lin 3 ,
Harry Quon 3 , Ramesh Rengan 3 , Elias R. Melhem 1 , Andrew Maudsley 2 , Harish Poptani 1
1 Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2 Radiology, University of Miami,
Miami, FL, United States; 3 Radiation Oncology, University of Pennsylvania, Philadelphia, PA, United States
Echoplanar spectroscopic imaging (EPSI) was performed serially in patients with brain metastasis undergoing whole brain radiation
therapy to assess metabolic alterations in the normal brain. NAA/Cr and Cho/Cr ratios were measured from dorsolateral-prefrontalcortex,
cingulate-gyrus, thalamus, hippocampus and basal ganglia. In general, a decrease in NAA/Cr was noted from several regions
while the Cho/Cr ratio decreased in some regions with a concomitant increase in other regions probably due to neurodegenerative
effects of whole brain radiation. These results suggest that EPSI may be used for detecting radiation toxicity to the normal brain in
patients with brain metastases treated with radiation therapy.
15:00 4280. Using MR Spectroscopy to Track Metabolic Changes in Glioblastoma After One
Dose of Cediranib
Heisoog Kim 1,2 , Ciprian Catana 1 , Eva-Maria Ratai 1 , Wei-Ting Zhang 1 , Ovidiu C.
Andronesi 1 , Tracy T. Batcheolor 3 , Rakesh K. Jain 4 , Alma Gregory Sorensen 1
1 A.A.Martinos center, Massachusetts General Hospital, Charlestown, MA, United States; 2 NSE/HST,
Massachusetts Institute of Technology, Cambridge, MA, United States; 3 Neurology, Massachusetts General
Hospital, Boston, MA, United States; 4 Radiology, Massachusetts General Hospital, Boston, MA, United States
This study investigated early changes in predominant metabolites for assessment of tumor response to anti-angiogenic agents in rGBM
using 1H-MRS. After one dose, NAA/norCre in ET showed a significant increase in good-OS patients (12/19) and no such increase in
poor-OS. NAA/Cho increased in good-OS, while decreasing in poor-OS. There were no significant changes in norCre or MRI
parameters, including T1, FLAIR, and ADC. The change in NAA/norCre after one dose suggests a revival of neuronal activity as well
as a recovery of metabolite concentrations due to reduction of edema. NAA/Cho changes also seem to correlate well with overall
survival.
15:30 4281. Combining High Resolution Magic Angle Spinning H1 NMR and Molecular
Genomics Predicts Survival in Brain Tumor Patients Better Than Either Methodology Alone
Loukas G. Astrakas 1,2 , Konstantinos D. Blekas 3 , Ovidiu C. Andronesi 1,4 , Michael N.
Mindrinos 5 , Peter M. Black 6 , Laurence G. Rahme 7 , A Aria Tzika 1,4
1 NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Shriners Burns
Institute, Harvard Medical School, Boston, MA, United States; 2 Department of Medical Physics, University of
Ioannina, Ioannina, Greece; 3 Department of Computer Science, University of Ioannina, Ioannina, Greece;
4 Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Athinoula A. Martinos
Center of Biomedical Imaging, Boston, MA, United States; 5 Stanford Genome Technology Center, Department
of Biochemistry, Stanford University School of Medicine, Palo Alto, CA, United States; 6 Neurosurgery,
Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States; 7 Molecular Surgery
Laboratory, Department of Surgery, Massachusetts General Hospital and Shriners Burn Institute, Harvard
Medical School, Boston, MA, United States
Our aim was to develop a novel approach that combines high-resolution magic angle spinning (HRMAS) H1 NMR and genomics in
the same biopsies to improve prognostication of brain tumors. We employed a linear Support Vector Machine combined with the
robust minimum redundancy – maximum relevance feature selection scheme, and applied our algorithm to combined HRMAS 1H
MRS and microarray data of the same adult brain tumor biopsies. Our results demonstrate that we are able to produce accurate and
meaningful data and introduce a novel classification scheme that predicts a clinically meaningful parameter such as survival better
than either method alone.
Tuesday 13:30-15:30 Computer 74
13:30 4282. Correlation Between Diffusion Tensor and Perfusion Imaging in Segmented
Enhancing Lesion with High Grade Glioma
Naomi Morita 1,2 , Masafumi Harada 1 , Eva Zacharaki 2 , Priyanka Bhatt 2 , Sanjeev Chawla 2 ,
Elias R. Melhem 2 , Hiromu Nishitani 1
1 Radiology, Tokushima University Hospital, Tokushima, Japan; 2 Radiology, University of Pennsylvania,
Philadelphia, PA, United States
Knowledge about microvascularity, angiogenesis or tumor cellularity is important in determing tumor grade. The purpose of this study
was to determine whether there are any correlations between ADC, FA and rTBV value in segmented enhancing lesion within tumor.
Thirty three brain tumor patients with contrast enhancement on MRI underwent DTI and PWI. FA, ADC and rTBV values were
measured in the segmented enhancing area within tumor. FA and rTBV had a negative correlation (p