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on the occipital cortex of five healthy volunteers. Spectra were analyzed with LCModel fitting. From monoexponential fitting of the LCModel estimates at the selected TE¡¯s, apparent T2¡¯s of Glu, Gln, and myo-inositol (mIns) were measured to be 160 - 170 ms. Further, the signal strengths measured with TR = 8 s were extrapolated to zero TE using the estimated T2 values. The concentration ratio with respect to creatine was estimated to be 8.2¡¾1.3, 4.6¡¾0.6, 9.5¡¾0.8, and 1.1¡¾0.1 (mean¡¾SD, N = 5) for Glu, mIns, NAA, and GPC+PC, respectively. 15:00 3331. Measurement of Proton T2 of Coupled-Spin Metabolites in Gray and White Matter in Human Brain at 3T Changho Choi 1 , Aditya Patel 1 , Deborah Douglas 1 , Ivan Dimitrov 1,2 1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2 Philips Medical Systems, Cleveland, OH, United States Measurement of the transverse relaxation times of brain metabolites including coupled-spin metabolites such as glutamate (Glu) and myo-inositol (mIns) in gray and white matter, at 3T, is reported. Four pairs of PRESS (point resolved spectroscopy) subecho times, which were obtained with numerical analyses of the sequence for optimal selectivity of Glu and mIns, were used for T2 measurement. Single-voxel measurements were carried out on the gray-matter (GM) and white-matter (WM) dominant regions in the occipital lobe of five healthy adult brains. The Glu T2 was measured to be similar between GM and WM (161±18 and 169±22 ms, respectively). Myo-inositol, creatine, and choline also exhibited similar T2 between GM and WM, but the T2 of N-acetylaspartate (2.01 ppm) was significantly different between GM and WM (262±16 and 326±21 ms, respectively), with p = 0.001. Wednesday 13:30-15:30 Computer 11 13:30 3332. In Vivo Detection of Serine in Human Brain by Constant-TE Difference Editing at 3T Changho Choi 1 , Deborah Douglas 1 , Aditya Patel 1 , Ivan Dimitrov 1,2 1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2 Philips Medical Systems, Dallas, OH, United States A proton MRS strategy for detection of serine (Ser) in human brain at 3T is proposed. Spectral difference of multiplet at different subecho times of triple refocusing at a constant total echo time was utilized to measure Ser and cancel the overlapping creatine (Cr) 3.92-ppm singlet via subtraction. A 50-ms non-spatially selective 180° RF pulse was applied between the 180° pulses of a PRESS sequence. A pair of subecho time sets, (TE1, TE2, TE3) = (70, 50, 135) and (35, 135, 85) ms, was obtained from density-matrix simulations. An in vivo test of this difference editing was conducted on the occipital cortex of a healthy adult brain. From spectral fitting of sub- and difference-spectra by LCModel, the serine to N-acetylaspartate concentration ratio was estimated as 0.05. 14:00 3333. Regional Difference in Glycine Concentrations in Human Brain as Measured by 1H- MRS at 7T in Vivo Changho Choi 1 , Ivan Dimitrov 1,2 , Deborah Douglas 1 , Aditya Patel 1 1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2 Philips Medical Systems, Cleveland, OH, United States Measurement of glycine (Gly) in the human brain by 1H-MRS at 7T is reported. A point-resolved spectroscopy (PRESS) sequence with subecho times optimized for differentiation between Gly and myo-inositol was applied for measuring the metabolites in the prefrontal and left frontal cortices of a healthy adult brain, which are gray and white matter dominant, respectively. The Gly-tocreatine concentration ratios were observed to be approximately 2-fold higher in prefrontal than in left frontal. This result suggests that Gly may be present predominantly in gray matter compared to white matter. 14:30 3334. J Refocused Coherence Transfer Spectroscopic Imaging at 7T Jullie W. Pan 1 , Nikolai Avdievich 1 , Hoby P. Hetherington 1 1 Yale University School of Medicine, New Haven, CT, United States The detection of amino acids at ultra high field is enhanced due to improved spectral resolution in comparison to 3T. However, due to J-modulation and T2 losses short spin echo acquisitions are typically used at 7T. Unfortunately, broad macromolecule resonances, visible at short TE, can make accurate detection of the metabolites difficult. J refocused coherence transfer spectroscopy is known to suppress J-modulation of coupled spin systems, thereby allowing longer echo times and suppressing macromolecule contamination. We describe simulation and implementation of a J-refocused transfer sequence for spectroscopic imaging of glutamate and glutamine in the human brain at 7T. 15:00 3335. Correction of Cerebral Metabolite Concentrations for Brain Tissue in Proton Spectroscopic Imaging Kuan-Ting Wu 1 , Chen-Shuan Huang 1 , Stefan Posse 2,3 , Shang-Yueh Tsai 1 1 Department of Electrical Engineering, Chang Gung University, Tao Yuan, Taiwan; 2 Department of Neurology, University of New Mexico School of Medicine, Alberquerque, NM, United States; 3 Department of Electrical & Computer Engineering, University of New Mexico , Alberquerque, NM, United States A processing procedure is proposed to do the tissue type correction for metabolite concentrations on spectroscopic imaging. Tissue segmentation is first done on 3D high resolution T1 images (MPRAGE). Image registration provided by SPM8 software is then applied to generate GM, WM and CSF probability maps at corresponding slice of spectroscopic imaging for the correction of metabolite concentrations. Our results showed that concentration correction can be done well on two segmentation methods and integration of SPM into tissue type correction is useful for future application of MRSI at different locations and slice orientations.
Thursday 13:30-15:30 Computer 11 13:30 3336. Absolute Metabolite Quantification in Human Brain Using Short Echo-Time CSI and a Phased-Array Headcoil. Petra Pouwels 1 , Marjan Steenweg 2 , Frederik Barkhof 3 , Marjo van der Knaap 2 1 Physics & Medical Technology, VU University Medical Center, Amsterdam, Netherlands; 2 Child Neurology, VU University Medical Center, Amsterdam, Netherlands; 3 Radiology, VU University Medical Center, Amsterdam, Netherlands Absolute metabolite concentrations in human brain were obtained from short echo-time CSI (TR/TE 3000/30 ms, 6 averages, 19 minutes) using a phased-array headcoil. A voxel-wise calibration was based on a combination of transmitter amplitude and water reference scans obtained with both body- and headcoil (
Page 1 and 2: ELECTRONIC POSTER Cartilage Hall B
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depending on its linear or centric
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3Tesla using a 32 channel cardiac c
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States; 5 Chemistry & Chemical Engi
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similar set of fully sampled data.
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demonstrated 35% improvement in blo
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and 13 patients, including peak and
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facilitate in the robust and reprod
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accurate quantification. The -goal
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and then auto-transplanted back to
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sampling patterns which are tailore
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with potential for improving diagno
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Receive Arrays Hall B Monday 14:00-
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heart between 20 and 40°C. As a re
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challenges for its simultaneous com
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experimental results showed the bes
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Arterial Spin Labeling: Methods Hal
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using both methods but the differen
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estimates. Differences in delays an
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angioplasty balloon in the aorta. T
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Cell Tracking II Hall B Monday 14:0
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are not sensitive to early abnormal
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were observed from the preCG and IC
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Vergata"; 6 Cognition and Cognitive
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secular-T2 peaks revealed significa
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Multiple Sclerosis I Hall B Monday
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independent predictors of disabilit
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Developing Brain I Hall B Monday 14
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suggests myelination or a reduction
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improvements in motor deficit over
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T2 and between lesion volume and AD
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significantly in rats exposed to EC
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Breast MR Hall B Monday 14:00-16:00
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therapies. MRI characteristics of t
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information is a novel approach. Th
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Metabolism Liver & Other II Hall B
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Body Diffusion Hall B Monday 14:00-
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prevention. In this study we have e
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present initial results in terms of
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14:30 4794. Bax-Deficiency Reduces
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of Cardiology, Munich University Ho
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appropriately describes the uptake
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tumour. A significant reduction in
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14:30 4838. Detection and Improveme
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15:00 4846. The Assessment of Early
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Our results indicate that the propo
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egularizing terms that may affect t
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times due to the need of additional
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proposed homotopic L0 minimization
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1 Imaging Division, UMC utrecht, Ut
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frequency k-space data are processe
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cylinders trajectory and have imple
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still requires scan durations not a
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perform the AC of the SPECT data. T
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egularization parameter is adapted
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IDEAL knee MRI data is proposed. Va
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14:30 5129. Design of Iron Sensitiv
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