ELECTRONIC POSTER - ismrm

15:00 4461. Altered Prefrontal-Amygdala Structural Connectivity in Adolescents Prenatally
Exposed to Cocaine
Priya Santhanam 1 , Zhihao Li 1 , Longchuan Li 1 , Claire Coles 2 , Mary Ellen Lynch 2 ,
Xiaoping Hu 1
1 Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, GA,
United States; 2 Department of Psychiatry and Behavioral Sciences, Emory University
As prenatal cocaine exposure (PCE) is known to affect emotional regulation, and since we have previously shown a functional
disconnect in the PCE group between regions responsible for such regulation (VMPFC: ventral medial prefrontal cortex and bilateral
amygdala), the present study examined the effect of PCE on structural connectivity between the VMPFC and amygdala. Using
probabilistic tractography to identify tracts, results showed significantly lower tract volume and FA along the tracts connecting the
VMPFC and left amygdala in the PCE group versus controls. This reduced structural integrity may affect functional connectivity and
thus emotional regulation in individuals with PCE.
Wednesday 13:30-15:30 Computer 85
13:30 4462. Evidence for a Decreased Activity of the Resting State Motor Network in Patients
with ALS
Massimo Filippi 1 , Martina Absinta 1 , Federica Agosta 1 , Maria A: Rocca 1 , Paola
Valsasina 1 , Stefania Sala 1 , Nilo Riva 2 , Alessandro Prelle 3 , Domenico Caputo 4 , Michele
Perini 5 , Raffaella Fazio 2 , Giancarlo Comi 2
1 Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific
Institute and University Hospital San Raffaele, Milan, Italy; 2 Department of Neurology, Scientific Institute and
University Hospital San Raffaele, Milan, Italy; 3 Dino Ferrari Center, Department of Neuroscience, University of
Milan, Milan, Italy; 4 Department of Neurology, Scientific Institute Fondazione Don Gnocchi, Milan, Italy;
5 Department of Neurology, Ospedale di Gallarate, Gallarate, Italy
Functional connectivity within the sensorimotor networks during rest were explored in 19 amyotrophic lateral sclerosis (ALS)
patients. Relationship between resting state (RS) fMRI and corticospinal tract (CST) damage was assessed. ICA analysis revealed two
networks related to the sensorimotor system. ALS patients had voxels of decreased RS connectivity in the left primary sensorimotor
cortex (SMC). Compared with controls, ALS patients also showed decreased average percentage RS signal change in several
sensorimotor regions. Decreased RS activity in the SMC correlated with CST damage. Dysfunction of RS sensorimotor connectivity
in ALS is likely to be a response to a selective CST damage.
14:00 4463. Comparison of Cortical Stimulation and FMRI for Language and Motor
Localization in Pediatric Patients
Andrew Poliakov 1 , Dennis Shaw 2 , Hillary Shurtleff 3 , Molly Warner 3 , Russell Saneto 4 ,
John Kuratani 4 , Edward Novotny, Jeff Ojemann 5
1 Radiology , Seattle Children's Hospital, Seattle, WA, United States; 2 Radiology, Seattle Children's Hospital,
Seattle, WA, United States; 3 Neurology, Seattle Children's Hospital, Seattle, WA, United States;
4 Clinical&Translational Science, Seattle Children's Hospital, Seattle, WA, United States; 5 Neurological
Surgery, Seattle Children's Hospital, Seattle, WA, United States
We review our experience comparing fMRI to ESM for surgical planning in pediatric patients with intractable epilepsy.
14:30 4464. Clinical FMRI Memory Evaluation in Pediatric Patients
Andrew Poliakov 1 , Hillary Shurtleff 2 , Molly Warner 2 , Dennis Shaw 3 , Sumit Pruthi 1 ,
Samuel Browd 4 , Edward Novotny 4 , Jeff Ojemann 4
1 Radiology , Seattle Children's Hospital, Seattle, WA, United States; 2 Neurology, Seattle Children's Hospital,
Seattle, WA, United States; 3 Radiology, Seattle Children's Hospital, Seattle, WA, United States; 4 Integrative
Brain Research, Seattle Children's Hospital, Seattle, WA, United States
We developed a evaluated and fMRI paradigm for visual-spatial memory testing in pediatric patients
15:00 4465. Altered Brain Activity of Defautl Mode Network in Patients with Liver Cirrhosis
Tun Wei Hsu 1,2 , Wei Che Lin 1,3 , Ching Po Lin 1
1 Institute of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan;
2 Department of Diagnostic Radiology, Taipei Veterans General Hospital, Taipei, Taiwan; 3 Department of
Diagnostic Radiology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan
Hepatic encephalopathy (HE) is one of the major complications of liver cirrhosis and a complex neurophysiological syndrome. It will
be acts of confusion, personality changes, conscious changes and ups and downs of the neurological manifestations. Our purpose of
this study is to investigate abnormalities of default mode networks in patients with liver cirrhosis.