ELECTRONIC POSTER - ismrm

15:30 4665. Colonic Response to an Experimental Model of Human Diarrhoeal Disease
Elisa Placidi 1 , C. L. Hoad 1 , L. Marciani 2 , R. C. Spiller 2 , P. A. Gowland 1
1 SPMMRC, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom;
2 Nottingham Digestive Diseases Centre Biomedical Research Unit, University of Nottingham, Nottingham,
United Kingdom
MRI was used to investigate the colonic response to two contrasting test meals: a readily absorbable glucose drink (control) and a non
absorbable mannitol drink, which acts as a model of acute diarrhoeal disease. Eight healthy volunteers were imaged on a 1.5 T Philips
Achieva scanner with several sequences up to 8 hours after the drink, to assess changes in the ascending colon in terms of water
content, volume, and image signal intensity. Differences between the two conditions have been quantified. A scoring system based on
subjective assessment of colonic contents has also been developed.
Tuesday 13:30-15:30 Computer 98
13:30 4666. Comparison Study on Differentiating Active from Remissive Crohn’s Disease by
3.0T and 1.0T MRI
Ambreen Sattar 1 , J Zhu 2 , Y Yu 2 , L Hamm 2 , Y Ye 2 , Y Xuan 2 , J Hu 2
1 Radiology, Wayne State University, Detroit, MI, United States; 2 WSU MR RESEARCH, Wayne State
University, detroit, MI, United States
This study analyzes the abiltiy of 3.0 T MRI to better evaluate the activity of active vs remissive Crohn's disease over 1.0 T MRI.3.0 T
magnet is better capable of detecting various signs of active Crohn's diseases such as Stenosis, bowel wall thickening and bowel wall
enhancement. MRI is safer option because it does not uses ionizing radiation and provides better diagnostic outcome in staging disease
which can significantly alter treatment options offered by the physician.
14:00 4667. Performance of Non-Contrast MR Enterography to Localize and Predict Disease
Activity in Crohn's Disease.
Srigouri Yalamanchili 1 , Michael Macari 1 , Rafael Rivera 1 , Danny Kim 1 , Alec Megibow 1 ,
James Babb 1 , Joseph Levy 1 , Kerry Zabriskie 1 , Sooah Kim 2
1 New York University; 2 New York University, New York, NY, United States
Secific findings at MR imaging- mural T2 high signal intensity and contrast enhancement patterns- have been proposed as accurate
markers of disease activity. The purpose of our study is to assess the performance using conventional non-contrast MR imaging
sequences as a tool to localize and predict disease activity in Crohn’s disease in comparison to post-contrast images. Thirty patients
referred for MR enterography were evaluated at 1.5 T using steady state free precession, single shot fast spin echo, fat suppressed T2,
and pre- and post contrast enhanced T1-weighted sequences. Images were reviewed by two radiologists in two separate sessions; the
readers interpreted non-contrast images of MRI during the first session and whole images including post-contrast sequences during the
second session. The readers evaluated the presence or absence of disease in regard to the presence of active inflammation using a sixpoint
grading system (0, No evidence of disease; 1, definite absence of active inflammation; 2, probable absence of active
inflammation; 3, equivocal; 4, probable presence of active inflammation; and 5, definite presence of active inflammation). Reference
standard was constructed by combining surgical, endoscopy, physical, and all available imaging findings. There were 34 bowel
segments with active inflammation on reference standard in 18 subjects (proximal ileum, n=1, distal ileum, n=4; terminal ileum, n=16;
cecum, n=6; ascending colon, n=1; rectosigmoid, n=2). Inter-reader agreement was significantly higher for whole imaging including
post-contrast images relative to non-contrast images (Kappa 0.31 for non-contrast and 0.41 for whole images). Although there is no
significant difference localizing abnormal bowel segment involved with Crohn’s disease using non-contrast images, inter-reader
agreement, sensitivity, and accuracy are significantly higher in the assessment of active disease adding post-contrast images to noncontrast
images for MRI interpretation.
14:30 4668. The Effect of High Fat or High Carbohydrate Meals on the Gastrointestinal Tract:
A MRI Study
Eleanor F. Cox 1 , Michael Mellows 2 , Susan E. Pritchard 1 , Mahamoud Hussein 1 , Caroline
L. Hoad 1 , Carolyn Costigan 3 , Luca Marciani 2 , Robin C. Spiller 2 , Penny A. Gowland 1
1 SPMMRC, Physics & Astronomy, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom;
2 Nottingham Digestive Diseases Centre, NIHR BRU, Nottingham University Hospitals, Nottingham, United
Kingdom; 3 Brain & Body Centre, University of Nottingham, Nottingham, United Kingdom
The effect of a high fat (HF) meal and an equicaloric high carbohydrate (HC) meal on satiety, gastric volumes, small bowel water
content (SBWC) and gallbladder contraction (as a marker of CCK release) was investigated using MRI. The HF meal resulted in
increased fullness and decreased hunger and appetite compared with the HC meal. Gastric emptying was initially faster for the HF
meal. After 90 minutes, SBWC was greater after the HF meal than after the HC meal. This delayed increase may reflect delayed
emptying of fat which stimulates pancreatic secretions.