ELECTRONIC POSTER - ismrm

Thursday 13:30-15:30 Computer 34
13:30 3660. Monitoring Iron Chelation Effect in Hearts of Thalassaemia Patients with Improved
Sensitivity Using Reduced Transverse Relaxation Rate (RR2)
Jerry S. Cheung 1,2 , Wing-Yan Au 3 , Shau-Yin Ha 4 , Jens H. Jensen 5 , Dan Kim 5 , Abby Y.
Ding 1,2 , Iris Y. Zhou 1,2 , Hua Guo 5 , Truman R. Brown 6 , Winnie C.W. Chu 7 , Darshana D.
Rasalkar 7 , Pek-Lan Khong 8 , Gary M. Brittenham 9 , Ed X. Wu 1,2
1 Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Pokfulam, Hong
Kong SAR, China; 2 Department of Electrical and Electronic Engineering, The University of Hong Kong,
Pokfulam, Hong Kong SAR, China; 3 Department of Medicine, The University of Hong Kong, Pokfulam, Hong
Kong SAR, China; 4 Department of Pediatrics and Adolescent Medicine, The University of Hong Kong,
Pokfulam, Hong Kong SAR, China; 5 Department of Radiology, New York University School of Medicine, New
York, United States; 6 Department of Radiology, Columbia University, New York, United States; 7 Department
of Diagnostic Radiology and Organ Imaging, The Chinese University of Hong Kong, Hong Kong SAR, China;
8 Department of Diagnostic Radiology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China;
9 Department of Pediatrics, Columbia University, New York, United States
Accurate MRI characterization of myocardial iron is needed to improve the diagnosis and management of thalassaemia patients with
transfusional iron overload. This study aimed to demonstrate that a new transverse relaxation index, the reduced R2 (RR2) that is
estimated from non-monoexponential multi-echo CPMG signal decay and sensitive to ferritin iron, could detect the myocardial iron
changes immediately following 1-week iron chelation suspension in thalassaemia patients at 3T.
14:00 3661. Quantitative T1 and T2 Measurements of Tissue Characteristics in Myocardial
Infarction – Pilot Results at 3T
Stefan K. Piechnik 1 , Erica Dall'Armellina 1 , Vanessa M. Ferreira 1 , Lowri E. Cochlin 2 ,
Jürgen E. Schneider 1 , Stefan Neubauer 1 , Matthew D. Robson 1
1 Cardiovascular Medicine, OCMR, Oxford University , Oxford, Oxfordshire, United Kingdom; 2 Dept of
Physiology, Anatomy and Genetics, Oxford University, Oxford, Oxfordshire, United Kingdom
We present preliminary results of T1- and T2-mapping at 3T in sub-acute myocardial infarction to demonstrate the ability of
quantitative CMR in delineating myocardial tissue changes following an ischemic event.
14:30 3662. Free-Breathing, Single Shot Fat-Water Separated Cardiac Imaging with Motion
Corrected Averaging
Peter Kellman 1 , Diego Hernando 2 , Saurabh Shah 3 , Christophe Chefd'hotel 4 , Z-P Liang 2 ,
Andrew E. Arai 1
1 National Institutes of Health, Bethesda, MD, United States; 2 University of Illinois, Urbana, IL, United States;
3 Siemens Medical Solutions, Chicago, IL, United States; 4 Siemens Corporate Research, Princeton, NJ, United
States
A rapid fat/water separated imaging protocol has been developed for free-breathing cardiac applications for cases where patients have
difficulty breath-holding or have significant arrhythmias. The method combines a 2 echo GRE acquisition and parallel imaging, and
may be used with repeated measurements and motion corrected averaging to further improve image quality. The method has been
applied to both pre-contrast and late enhancement imaging.
15:00 3663. Navigator Guided High-Resolution Single-Shot Black-Blood TSE Images Using
ZOOM and Sensitivity Encoding (SENSE) on a 32 Channel RF System
Raja Muthupillai 1 , Amol Pednekar 2 , Claudio Arena 1 , Scott D. Flamm 1 , Benjamin Y.
Cheong 1
1 Diagnostic and Interventional Radiology, St. Luke's Episcopal Hospital, Houston, TX, United States; 2 Philips
Healthcare
We demonstrate that by using a judicious combination of reduced FOV imaging (ZOOM), Sensitivity Encoding (SENSE), and halfscan,
it is feasible to obtain diagnostic quality single-shot (SSH) dual-inversion recovery prepared black blood(BB) turbo spin
echo(TSE) images with minimal image blurring during normal respiration. The results of the study, performed on 8 asymptomatic
subjects, show that SSH T2-TSE images acquired using ZOOM+SENSE under navigator triggering, yield images with quality that is
comparable to conventional multi-shot BB-TSE images acquired over a 14-16 heart beat breathhold.