ELECTRONIC POSTER - ismrm

14:30 4359. Large-Scale ADC Histogram Analysis of the Brain Aging: Normal Versus
Abnormal (667 Subjects, 2 Days-93.8 Years)
Memi Watanabe 1 , Noreen Ward 1 , Al Ozonoff 2 , Steven Kussman 1 , Koji Tanabe 1 , Kaan
Erbay 1 , Naoko Saito 1 , Hernan Jara 1,3 , Osamu Sakai 1
1 Department of Radiology, Boston Medical Center, Boston University School of Medicine, Boston, MA, United
States; 2 Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States;
3 Department of Biomedical Engineering, Boston University, Boston, MA, United States
Purpose: To study age dependencies of ADC histogram and impact of brain abnormalities on ADC in a large and wide age ranged
population. Methods: Brain data of 667 subjects (2 days-93.8 years) were obtained by DW-SE-sshEPI and ADC histograms of the
whole brain were generated. The subjects were divided into normal and abnormal groups by MR findings and clinical histories.
Results: The abnormal group showed higher ADC peak values compared with the normal. Conclusion: The aging patterns of ADC
peak values of normal and abnormal brain groups have been demonstrated in a large and wide age ranged population.
15:00 4360. Cortical Thickness Is Linked to Executive Functioning in Adulthood and Aging.
Agnieszka Z. Burzynska 1 , Irene E. Nagel 1 , Claudia Preuschhof 1 , Sebastian Gluth 1 , Lars
Bäckmann 1,2 , Shu-Chen Li 1 , Ulman Lindenberger 1 , Hauke R. Heekeren 1,3
1 Max Planck Institute for Human Development, Berlin, Germany; 2 Aging Research Center, Karolinska
Institutet, Stockholm, Sweden; 3 Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig,
Germany
We investigated the cortical structural underpinnings of executive functioning in 129 healthy adults (73 younger, 20-32 years; 56
older, 60-71 years). We measured executive functions by Wisconsin Card Sorting Test (WCST) and cortical thickness by applying
surface-based segmentation (Freesurfer). The structural underpinnings of WCST largely overlapped with previously defined WCST
functional patterns and the structure-performance relationship was stronger in later than in earlier adulthood. Our data suggest that the
extent of structural preservation in old age differentiates between high and low performers, underscoring the need of taking
performance level into account when studying changes in brain structure across adulthood.
15:30 4361. Assessing the Corticospinal Tract with Multimodal Quantitative MRI
Pierre-Yves Herve 1 , Eleanor F. Cox 2 , Ashley Loftipour 2 , Olivier Mougin 2 , Sam Wharton 2 ,
Richard W. Bowtell 2 , Tomas Paus 1 , Penny A. Gowland 2
1 Brain & Body Centre, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2 SPMMRC,
Physics & Astronomy, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom
The study of human white matter fibre pathways was first performed on post-mortem material, notably via dissection or with the
Weigert staining method for myelinated fibres (Dejerine, 1895). More recently, diffusion weighted imaging emerged as a non-invasive
alternative for both the tracing and the measurement of quantitative parameters of fibre pathways. Here we use multimodal
quantitative imaging to assess differences between white matter structures.
Tuesday 13:30-15:30 Computer 79
13:30 4362. Mineralization of the Globus Pallidus as a Function of Age: Are There Major
Differences Between Caucasians and Chinese?
jiangtao liu 1 , E Mark Haccke 2 , Kuncheng li 1 , Manju liu 2 , Ana M. Daugherty 3 , Ambreen
Sattar 4 , bo wu 2
1 Radiology, Xuanwu hospital, Beijing, China; 2 MRI Institute for Biomedical research, Wayne State University,
Detroit, MI, United States; 3 Behavioral and Cognitive Neuroscience, Wayne State University, Detroit, MI,
United States; 4 Diagnostic Radiology, Wayne State University, Detroit, MI, United States
SWI images for 37 age and gender matched healthy paired subjects (Chinese versus Caucasians) were retrospectively reviewed. the
GP was measured in two adjacent slices. Two cutoffs were used and the percentage cutoff pixels between two groups was compared.
Mineralization increases with age in the GP whether measured with phase or magnitude. For the right globus pallidus, healthy Chinese
subjects have a higher percentage of mineralization at any age group while for the left side it tends to grow after age 40. SWI offers
the potential to examine differences in disease that might correlate with mineralization.
14:00 4363. Measuring T2 at Ultra High Field: Effects of Age and Sex
Eleanor F. Cox 1 , Susan E. Pritchard 1 , Peter J. Wright 1 , Tomas Paus 2 , Penny A.
Gowland 1
1 SPMMRC, Physics & Astronomy, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom;
2 Brain & Body Centre, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom
This study has examined the effects of age (40-75 years) and sex on the T2 of the human brain at 7.0 T. The results show that there is
considerable variation in T2s across grey and white matter regions, and a trend for women to have longer WM T2s than men. The
white matter T2s of men changed with age but the T2s of women did not.