ELECTRONIC POSTER - ismrm

15:00 3615. Adaptive Method for Black Blood Cardiac Imaging in End-Systolic Rest Improves
Visualization of the Right Ventricular Wall
Brice Fernandez 1,2 , Julien Oster 2,3 , Maelene Lohezic 1,2 , Damien Mandry 2,4 , Olivier
Pietquin, 2,5 , Pierre-André Vuissoz 2,3 , Jacques Felblinger 2,3
1 Global Applied Science Lab., GE Healthcare, Nancy, France; 2 IADI lab., Nancy-Université, Nancy, France;
3 U947, INSERM, Nancy, France; 4 Departement of Radiology, CHU Nancy, Nancy, France; 5 IMS Research
Group, Supelec, Metz, France
Conventional Double Inversion Recovery Fast Spin Echo (DIR-FSE) sequence provides detailed anatomical information in cardiac
MRI. However, the preparation time required to cancel blood signal is too long to acquire DIR-FSE during the end-systolic rest. To
overcome this constraint, two methods are described. The first one relies on the assumption that the RR intervals are constant whereas
the second method is based on an adaptive RR interval prediction algorithm. These approaches were evaluated on 14 healthy
volunteers; results demonstrated the robustness of the adaptive method with a better delineation of the right ventricle wall than with
the conventional DIR-FSE.
Myocardial Perfusion: Experimental Models & Human Studies
Hall B Monday 14:00-16:00 Computer 32
14:00 3616. A New Quantitative Imaging Biomarker for Identifying Critical Coronary Artery
Stenosis with Myocardial BOLD MRI
Sotirios A. Tsaftaris 1,2 , Xiangzhi Zhou 2 , Debiao Li 2,3 , Rohan Dharmakumar 2
1 Electrical Engineering and Computer Science, Northwestern University, Evanston, IL, United States;
2 Radiology, Northwestern University, Chicago, IL, United States; 3 Biomedical Engineering, Northwestern
University, Evanston, IL, United States
Blood-oxygen-level dependent (BOLD) MRI may be used for detecting myocardial oxygenation changes secondary to coronary artery
stenosis (CAS). Under pharmacological stress, areas of the myocardium supplied by a stenotic coronary artery appear hypointense
relative to healthy regions in BOLD images. The purpose of this work is to present a fundamentally new approach for visualizing and
quantifying regional myocardial BOLD signal changes. This approach, tested in canines, relies on the statistical identification of
myocardial pixels affected by CAS, correlates strongly with true flow measurements, and most importantly, leads to a significant
increase in sensitivity to microvascular flow changes compared to previous approaches.
14:30 3617. Comparison of Systolic and Diastolic Myocardial Perfusion by Dynamic Contrast
Enhanced MRI
Aleksandra Radjenovic 1 , John D. Biglands 1 , Abdulghani Larghat 1 , John P. Ridgway 1 ,
Michael Jerosch-Herold 2 , John P. Greenwood 1 , Sven Plein 1
1 School of Medicine, University of Leeds, Leeds, England, United Kingdom; 2 Brigham and Women’s Hospital,
Harvard Medical School, Boston, MA, United States
Dynamic contrast-enhanced MRI was performed in 17 volunteers to simultaneously assess systolic and diastolic myocardial blood
flow (MBF). At rest transmural MBF estimates were similar in systole and diastole (1.6 ± 0.42 vs 1.7 ± 0.49 ml/g/min, p>0.05).
During adenosine-induced hyperaemia, MBF was significantly lower in systole than diastole (4.3 ± 0.93 vs 5.7 ± 1.7 ml/g/min, p <
0.0001). Subendocardial MBF was higher than subepicaridal MBF, apart from systole at stress where this relation was reversed. In
conclusion, estimates of hyperaemic MBF differ significantly between systole and diastole, following the expected physiological
pattern of preferential diastolic filling.
15:00 3618. Mouse Myocardial First-Pass Perfusion Imaging
Bram F. Coolen 1 , Rik PM Moonen 1 , Leonie EM Paulis 1 , Tessa Geelen 1 , Larry de Graaf 1 ,
Klaas Nicolay 1 , Gustav J. Strijkers 1
1 Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven,
Netherlands
A method that allows myocardial first-pass perfusion measurements in mice is presented. Using a combination of segmented
saturation-prepared FISP acquisition and GRAPPA parallel imaging allows a temporal resolution of one image every three heart beats
with an acquisition time of less than 16 ms. First-pass perfusion images showed the influx of contrast agent into the myocardium with
sufficient temporal resolution to derive semi-quantitative perfusion values. These were found significantly lower in a mouse with
myocardial infarction compared to healthy control mice.
15:30 3619. Theory-Based Single-Point T 1 Mapping for Quantitative Analysis of First-Pass
Cardiac Perfusion MRI: A Validation Study
Elodie Breton 1 , Daniel Kim 1 , Sohae Chung 1 , Leon Axel 1
1 Research Radiology - Center for Biomedical Imaging, New York University Langone Medical Center, New
York, NY, United States
Quantitative analysis of first-pass contrast-enhanced cardiac perfusion MRI requires the signal-time curve be converted to Gd-DTPA
concentration-time curve. A theory-based single-point T 1 measurement method has been proposed and validated in phantoms at 1.5T.
In this study at 3T, the sensitivity to B 1 variations and blood inflow of the single-point T 1 mapping method was first evaluated