ELECTRONIC POSTER - ismrm

Thursday 13:30-15:30 Computer 85
13:30 4466. fMRI in Systemic Lupus Erythematosus and Antiphospholipid Syndrome
Aziz M. Ulug 1 , An Vo 1 , Elisabeth Kozora 2,3 , Glendalee Ramon 4 , Joann Vega 4 , Robert D.
Zimmerman 5 , Doruk Erkan 4 , Michael D. Lockshin 4
1 The Feinstein Institute for Medical Research, Manhasset, NY, United States; 2 National Jewish Heath, Denver,
CO, United States; 3 University of Colorado Medical Center, Denver, CO, United States; 4 Hospital for Special
Surgery, New York, United States; 5 Weill Medical College of Cornell University, New York, United States
Fourteen SLE patients, five APL patients and four normal controls were studied using fMRI and DTI. We found significant DTI and
fMRI differences among three groups. In both patient groups, word generation task shows abnormal activation patterns in the frontal
areas suggestive of recruitment of these areas during these tasks. In the hippocampal area, there is a significant difference between
APL and SLE group during N-back, word generation and rhyming tasks. In addition to regional differences, there is also whole brain
diffusion changes between the patient groups and controls.
14:00 4467. Retinotopy Extension in Primary Visual Cortex Associated with Perimetry
Improvement in a Case of Hemianopia After Visual Restoration Therapy
Yi-Ching Lynn Ho 1,2 , Amandine Cheze 2 , Esben Thade Petersen 2,3 , Albert Gjedde 1,4 , Kong-
Yong Goh 5 , Yih-Yian Sitoh 2 , Xavier Golay 2,6
1 CFIN, University of Aarhus, Aarhus, Denmark; 2 Neuroradiology, National Neuroscience Institute, Singapore,
Singapore; 3 Clinical Imaging Research Centre, NUS, Singapore; 4 University of Copenhagen, Denmark; 5 Eye
Institute, Tan Tock Seng Hospital, Singapore; 6 Institute of Neurology, UCL, London, United Kingdom
So far, no clear physiological correlates have been given for the apparent visual field improvements of patients with post-chiasmal
lesions after treatment, such as Visual Restoration Therapy (VRT). Using fMRI retinotopic mapping, we assessed a patient with
complete homonymous hemianopia before and after VRT. The patient demonstrated residual neurovascular function and limited
retinotopic organization around the lesion before therapy. Post therapy, the retinotopic representation around the lesion was modestly
extended along with perimetry improvements, which may, to our knowledge, be the first report on primary visual cortex retinotopy
recovery via ad hoc treatment of a patient with visual field loss.
14:30 4468. fMRI Study of Sound-Color Synesthesia
Jianli Wang 1 , Melissa Robinson-Long 2 , Khristy Thompson 3 , Paul J. Eslinger 2,4 ,
Catherine Lemley 5
1 Radiology, Penn State University College of Medcine, Hershey, PA, United States; 2 Neurology, Penn State
University College of Medcine, Hershey, PA, United States; 3 Biology, Elizabethtown College, Elizabethtown,
PA, United States; 4 Neural and Behavioral Sciences, Penn State University College of Medicine, Hershey, PA,
United States; 5 Psychology, Elizabethtown College, Elizabethtown, PA, United States
Synesthesia is a condition that stimulation of one sensory modality will automatically trigger another un-stimulated perception
modality. Here we reported the first fMRI study on sound-color synesthesia. The result shows that color center, angular gyrus and
superior parietal cortex are involved in some sound-color photisms. Background noise control is critical in the study of sound-color
synesthesia using fMRI. Our observation suggests that there may be different levels or subcategories of sound-color synesthesia and
attention distraction may be an effective method for defining subcategories of this synesthesia.
15:00 4469. fMRI in Patients with Lumbar Disc Disease: A Paradigm to Study Patients Over
Time
Harish A. Sharma 1 , Raj Gupta 2 , William Olivero 3
1 Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL, United States; 2 University of
Illinois College of Medicine; 3 Neurosurgery, Carle Foundation Hospital
Using fMRI to study pain has revealed new information about how the brain responds to painful stimuli and what regions of the brain
are activated during pain. Unfortunately, many of the paradigms that are used in fMRI studies either fail to replicate the subject’s pain
or painful stimuli is used in volunteers without pain. Moreover, longitudinal fMRI studies that follow patients who develop chronic
pain from the acute phase of pain have not been performed.We developed an fMRI paradigm that reliably mimics a clinical pain
syndrome in patients who have low back pain and leg pain from acute lumbar radiculopathy and lumbar degenerative disc disease.