ELECTRONIC POSTER - ismrm

examine this possible effect, we excluded subjects with white matter lesions from our study cohort and performed TBSS. Our results
were consistent with what literature reports.
14:00 4475. Probabilistic Fiber Tracking from the Pre-SMA and SMA Proper: Implications for
Language and Motor White Matter Networks
Kyung K. Peck 1 , Seyedeh Jenabi 2 , Robert Young, Lucas Parra 2 , Andrei Holodny
1 Medical Physics and Radiology, Memorial Sloan-Kettering Cancer Center, New York, United States; 2 City
University of New York
In this study, we seek to expand on this study by using diffusion tensor imaging to compare the pattern of white matter fibers
originating from two different fMRI guided seed regions; the pre-SMA and the SMA-proper defined by fMRI language and motor
paradigm respectively. We hypothesized that pre-SMA seed derived from the language paradigm will connect more readily to the
frontal areas known to be associated with language function including Broca’s Area
14:30 4476. Correlation of Quantitative Sensori-Motor Tractography with Clinical Grade of
Cerebral Palsy
Richa Trivedi 1 , Shruti Agarwal 2 , Vipul Shah 3 , Puneet Goyal 4 , Vimal K. Paliwal 5 , Ram KS
Rathore 6 , Rakesh Kumar Gupta 7
1 NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences, Delhi, India; 2 Mathematics and
Statistics, Indian Institute of Technology, Kanpur, Uttar Pradesh, India; 3 3Pediatric Orthopedic Surgery unit,
Bhargava Nursing Home, Lucknow, Uttar Pradesh, India; 4 Anesthesiology, Sanjay Gandhi Post Graduate
Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 5 Neurology, Sanjay Gandhi Post Graduate
Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 6 Mathematics and Statistics, Indian Institute of
Technology, , Kanpur, Uttar Pradesh, India; 7 Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical
Sciences, Lucknow, Uttar Pradesh, India
Diffusion tensor tractography using FACT algorithm was performed on 39 children with different grades of cerebral palsy (CP)
defined using the Gross Motor Function Classification System (GMFCS) to look for probable correlation between tract-specific DTI
metrics in sensorymotor pathways and clinical grades. A significant inverse correlation was observed between fractional anisotropy
(FA) in both sensory and motor pathways and clinical grades. In this study we extend our understanding of the pathophysiology of CP
by showing that DTI measures in both motor and sensory pathways reflects the degree of motor deficits.
15:00 4477. Study of Neuropsychiatric Systemic Lupus Erythematosus with DTI and FAIR
Xiaozhen Li 1 , Zhengguang Chen 2
1 Radiology, Peking Union Medical College Hospital, Beijing, China; 2 Radiology, First Hospital of Tsinghua,
Beijing, China
Conventional neuroimaging cannot help us either to differentiate between chronic and acute brain lesions or to improve in our
understanding of systemic lupus erythematosus (SLE) pathogenesis because of the high probability of a Neuropsychiatric SLE
(NPSLE) event. The fMRI including DTI, which demonstrates the tissue water mobility in brain tissue, and flow-sensitive alternating
inversion recovery (FAIR), which reveals the relative cerebral blood flow, may help to further assess the possible abnormality in
neuronal and neural vascular reactivity in NPSLE. In this study we found in combination of ADC, FA, rCBF have high sensitivity in
detecting earlier pathologic changes in NPSLE.
Wednesday 13:30-15:30 Computer 86
13:30 4478. Diffusion Tensor Imaging Permits Detection of Disjunct MD and FA Changes in the
Basal Ganglia in Patients with Susac’s Syndrome
Michael Deppe 1 , Ilka Kleffner 1 , Siawoosh Mohammadi 1 , Wolfram Schwindt 2 , Katja
Deppe 3 , Simon S. Keller 1 , E. Bernd Ringelstein 1
1 Neurology, University of Münster, Münster, Germany; 2 Radiology, University of Münster, Münster;
3 Neurology, Franz Hospital Dülmen
By employing a highly effective spatial normalization technique for diffusion weighted images we found evidence that DTI is
sensitive in detecting damage to white matter that is of normal appearance in Susac's Syndrome using conventional MRI methods.
Grey matter (GM) alterations in Susac's syndrome are also detectable by DTI as circumscribed FA and MD increases in the basal
ganglia that are also not observed using conventional MRI. The alterations in basal ganglia MD and FA are differentially localized to
the pallidum and putamen, respectably.