ELECTRONIC POSTER - ismrm

depending on its linear or centric k-space trajectory. Then, the centric k-space trajectory T 1 mapping pulse sequence was validated in
vivo against a multi-point saturation recovery T 1 measurement method in the left ventricular myocardium and cavity.
Tuesday 13:30-15:30 Computer 32
13:30 3620. Optimization of Spiral Pulse Sequences for First-Pass Myocardial Perfusion
Imaging
Michael Salerno 1 , Christopher M. Kramer 2 , Christopher Sica 3 , Craig H. Meyer 4
1 Department of Medicine, Cardiology, University of Virginia, Charlottesville, VA, United States; 2 Department
of Radiology, University of Virginia, Charlottesville, VA; 3 Biomedical Engineering, Hershey Medical Center,
Hershey, PA; 4 Biomedical Engineering, University of Virginia, Charlottesville, VA
Optimized Spiral Pulse Sequences may have advantages for clinical myocardial perfusion imaging. The goal of this project was to
evaluate how variations in the readout duration per interleaf, number of spiral interleaves, and spatial resolution affect the image
quality and artifacts for first-pass myocardial perfusion imaging using spiral trajectories in human subjects.
14:00 3621. A Fully Quantitative Pixel Based Approach for Measuring Myocardial Blood Flow
in First-Pass Contrast-Enhanced Perfusion MRI: Microspheres Validation in Dogs and
Feasibility Study in Humans
Li-Yueh Hsu 1 , Daniel W. Groves 1 , Anthony H. Aletras 1 , Peter Kellman 1 , Andrew E. Arai 1
1 National Institutes of Health, Bethesda, MD, United States
We developed a fully quantitative method to estimate myocardial blood flow (MBF) in first-pass contrast-enhanced perfusion MR
images at the pixel level. The results were validated in an animal model and show that the MR perfusion estimates correlated with
microspheres over a wide range of absolute MBF. To test feasibility in humans, the method was also applied to clinical perfusion MR
images to estimate pixel-wise MBF at rest and during stress.
14:30 3622. First-Pass Cardiac Perfusion Imaging of the Infarcted Rat Heart
Daniel James Stuckey 1 , Carolyn A. Carr 1 , Stephanie Meader 1 , Damian J. Tyler 1 , Kieran
Clarke 1
1 Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, Oxon, United Kingdom
We developed a first-pass cardiac perfusion imaging method which identified regions of perfusion deficit in the infarcted rat heart.
Seven days after infarction, cine-MRI was combined with first-pass imaging, which acquired one image per heartbeat during Gd-
DTPA bolus. Perfusion deficit at 7 days was larger in rats that went on to develop greater cardiac impairment by 42 days, and
provided a more accuracy early indicator of the extent of myocardial infarction than ejection fraction. First-pass MRI will be useful
for evaluation of rodent models of human disease and experimental therapies, including cytokine and stem-cell mediated angiogenesis
in the infarcted heart.
15:00 3623. Myocardial Perfusion MRI at 3.0T with Sliding-Window Conjugate-Gradient
HYPR for the Detection of Coronary Artery Disease
Heng Ma 1 , Lan Ge 2 , Dong Xu 1 , Qing Tang 1 , Han Li 1 , Yu Zhang 1 , Jiabin Liu 1 , Qi Yang 1 ,
Jing An 3 , Lixin Jin 4 , Renate Jerecic 4 , Xiangying Du 1 , Kuncheng Li 1 , Debiao Li 2
1 Xuanwu Hospital, Capital Medical University, Beijing, China; 2 Radiology, Northwestern University, Chicago,
IL, United States; 3 Siemens Mindit Magnetic Resonance Ltd, Shenzhen, China; 4 Siemens Ltd, Healthcare
Sector, China
SW-CG-HYPR is a promising method to improve the myocardial perfusion MR imaging with reduced acquisition window, increased
spatial coverage, improved spatial resolution and SNR. In this work, 10 patients with suspected CAD were scanned at 3.0T with SW-
CG-HYPR. Our initial results show that myocardial perfusion MRI at 3.0T with SW-CG-HYPR is feasible in a clinical population,
and has high image quality and diagnostic accuracy in patients with suspected CAD.
Wednesday 13:30-15:30 Computer 32
13:30 3624. Myocardial Perfusion Imaging with Variable Density Spiral Trajectories
Michael Salerno 1 , Christopher M. Kramer 2 , Craig H. Meyer 3
1 Department of Medicine, Cardiology, University of Virginia, Charlottesville, VA, United States; 2 Department
of Radiology, University of Virginia, Charlottesville, VA; 3 Biomedical Engineering, University of Virginia,
Charlottesville, VA
Variable density (VD) spiral trajectories are an efficient method for data acquisition and may be advantageous for first pass
myocardial perfusion imaging. By only partially correcting the variable density, k-space is weighted by a smooth function which
reduces Gibbs Ringing. This strategy is employed to further reduce dark-rim artifacts for spiral myocardial perfusion imaging.