ELECTRONIC POSTER - ismrm

14:30 3258. 3D-FSE-Cube of the Foot at 3TMRI: Comparison with 2D-FSE Images.
Mai Hanamiya 1 , Takatoshi Aoki 1 , Yoshiko Yamashita 1 , Yoshiko Hayashida 1 , Toru Sato 2 ,
Shigeru Hibino 3 , Atsushi Nozaki 3 , Yukunori Korogi 1
1 Radiology, University of Occupational and Environmental Health School of Medicine, Kitakyushu, Fukuoka,
Japan; 2 Clinical Radiology Service, University of Occupational and Environmental Health Hospital; 3 GE
Healthcare Japan
Our purpose is to compare 3D-FSE-Cube with 2D-FSE sequence for MR imaging of the ankle at 3.0T MR system. Eight healthy
volunteers were examined with 3D-FSE Cube (6 minutes 50 seconds) and 2D-FSE (axial, sagittal and coronal planes, total imaging
time; 11minutes 24 seconds), and 3D-FSE-Cube images were reformatted into images of same planes as 2D-FSE. Bone, cartilage,
fluid, and tendon SNRs and bone-tendon CNR were significantly higher with the 3D-FSE-Cube. The 3D-FSE-Cube sequence with
parallel imaging at 3.0T MR enables to reduce examination time preserving image quality and evaluate complex anatomy of the ankle
on multiple arbitrary planes.
15:00 3259. 3D-TSE-Imaging of the Ankle - A New Perspective?
Mike Notohamiprodjo 1 , Annie Horng 2 , Bernhard Kuschel 2 , Peter Bär 3 , Maximilian F.
Reiser, Christian Glaser
1 Institute for Clinical Radiology, University Hospitals Munich, Munich, Bavaria, Germany; 2 University
Hospitals Munich, Insitute for Clinical Radiology; 3 Siemens Sector Healthcare
The purpose of this study was to evaluate an optimized 3D-TSE-sequence for ankle-MRI at 3T. Fifteen volunteers and 25 patients
were examined at 3T with a dedicated 8-channel-ankle coil and the isotropic PDfs-weigthed 3D-TSE-sequence SPACE featuring
optimized variable flip angles, elliptical scanning and radial k-space readout for improved contrast and time efficient acquisition. In
comparison to current 2D-TSE-sequences, relevant SNR and CNR were significantly higher. The 3D-reconstruction capabilities
provided better visualization of small structures, ligaments and lesions. Diagnostic confidence was not significantly different in the
3D-TSE-sequence. This technique holds high potential for future ankle-MRI protocols.
Hyperpolarized Carbon-13 & Other Nuclei I
Hall B Monday 14:00-16:00 Computer 7
14:00 3260. A DNP Polarizer Designed for Clinical Use
Andrew M. Leach 1 , John Urbahn 1 , Denise Anderson 1 , Neil Clarke 2 , Timothy Skloss 3 , Jan
Henrik Ardenkjaer-Larsen 2
1 GE Global Research, Niskayuna, NY, United States; 2 GE Healthcare, Amersham, United Kingdom; 3 GE
Healthcare, Waukesha, WI, United States
Provides a description of a novel hyperpolarizer design that incorporates specific characteristics required for clinical application
including: 1) the ability to simultaneously process multiple doses; 2) no cryogen consumption; 3) a sterile product contained within a
disposable fluid path; and 4) an integrated quality control system that rapidly measures six product characteristics to ensure agent
safety and efficacy. The system has been demonstrated as a robust means to generate high volume doses for imaging studies. Device
functionality and process capability will be discussed.
14:30 3261. Potential for Polarization Measurement of Pre-Polarized [1- 13 C] Pyruvate in Vivo
Using Jcc Spectral Pattern
Albert P. Chen 1 , Charles H. Cunningham 2 , James Tropp 3 , Kayvan Keshari 4 , Mark
VanCriekinge 4 , John Kurhanewicz 4 , Ralph E. Hurd 5
1 GE Healthcare, Toronto, ON, Canada; 2 Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON,
Canada; 3 GE Healthcare, Fremont, CA, United States; 4 Radiology, UCSF, San Francisco, CA, United States;
5 GE Healthcare, Menlo Park, CA, United States
The ability to accurately measure or predict the polarization of hyperpolarized 13C metabolic imaging substrates at the time of the MR
experiment is necessary for quantitative kinetics data or metabolite concentrations. In this study, the feasibility of using asymmetry of
the pyruvate C2 resonance (from 1% natural abundance of [1,2- 13 C 2 ] pyruvate) to estimate the polarization of the [1- 13 C] pyruvate in
vivo is demonstrated.
15:00 3262. Non-Fourier Spatial Encoding for Improved Point-Spread-Functions in
Hyperpolarized 13C CSI Acquisitions
Albert P. Chen 1 , Ralph E. Hurd 2 , Charles H. Cunningham 3,4
1 GE Healthcare, Toronto, ON, Canada; 2 GE Healthcare, Menlo Park, CA, United States; 3 Imaging Research,
Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 4 Medical Biophysics, University of Toronto,
Toronto, ON, Canada
Metabolic imaging using pre-polarized substrates labeled with a 13C nucleus has proven to be a promising new tool. Often, chemicalshift
imaging (CSI) acquisitions are used to map the 13C resonances over 2D or 3D volumes so that 13C metabolic data from various
tissues can be compared. Due to the time constraints imposed by the relatively short lifetime of the hyperpolarized state, the spatial
dimensions of these acquisitions are often encoded with small matrix sizes (e.g. 8 x 8 x 16), resulting in a relatively poor point-spread
function (PSF). In this abstract, we have explored the use of non-Fourier spatial encoding to improve the PSF in both in-plane