ELECTRONIC POSTER - ismrm

15:30 4245. Automated Segmentation of Cortical and Subcortical Gray Matter Structures for
Evaluation of Alzheimer's Disease and Fronto-Temporal Dementia
Emil Malucelli 1 , David Neil Manners 1 , Claudia Testa 2 , Caterina Tonon 2 , Giovanni
Rizzo 2 , Roberto Poda 3 , Federico Oppi 3 , Michelangelo Stanzani Maserati 3 , Luisa
Sambati 3 , Bruno Barbiroli 2 , Roberto Gallassi 3 , Raffaele Lodi 2
1 Department of Internal Medicine, Aging and Nephrology , University of Bologna, Bologna, Italy; 2 Department
of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy; 3 Department of
Neurological Sciences, University of Bologna, Bologna, Italy
Objectives: To assess the ability of combined MR cortical structure volumetry and DTI to automatically detect regional brain changes
in patients with Alzheimer disease (AD) and Frontotemporal dementia (FTD). Methods: 9 AD patients, 7 FTD patients and 7 controls
were studied by 3D volumetric and DW MR imaging. An automated registration/segmentation pipeline defined cortical and
subcortical regions of interest, yielding structure volumes and mean diffusivity. Results. Diffuse volume reductions and MD increases
were found in both patient groups compared to controls. Conclusions: the protocol described has the potential to identify in vivo
surrogate markers for brain pathologic changes in neurodegeneration.
Tuesday 13:30-15:30 Computer 72
13:30 4246. DTI Measurements of Neurodegeneration in Early Alzheimer’s Disease: A Corpus
Callosum Study
Julio Acosta-Cabronero 1,2 , Guy B. Williams 1 , George Pengas 2 , Peter J. Nestor 2
1 Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge,
Cambridgeshire, United Kingdom; 2 Neurology Unit, Department of Clinical Neurosciences, University of
Cambridge, Cambridge, Cambridgeshire, United Kingdom
The splenium and genu of the corpus callosum (CC), which contain millions of inter-hemispheric fibres, were found to be abnormal in
early AD. In this study, we analysed the behaviour of several DTI measures in the subregions of the midline CC and assessed their
relationship with global cognitive data. We found that in both splenium and genu, axial and mean diffusion were better predictors of
the disease, whereas radial diffusion and particularly, fractional anisotropy exhibited strong correlations with cognitive performance in
the splenium only. The results suggest that the neurodegenerative processes affecting the splenium are different than in the genu.
14:00 4247. Functional Connectivity and Psychometrics as Early Biomarkers for Alzheimer's
Disease
Partick Rich 1 , Huiling Peng 2 , Jewell Thomas 2 , Joseph Mettenburg 3 , Tammie Benzinger 3 ,
John Morris 2 , David Balota 4 , Beau Ances 5
1 Psychology, Grinnell College, Grinnell, IO, United States; 2 Neurology, Washington University in St. Louis, St.
Louis, MO, United States; 3 Radiology, Washington University in St. Louis, St. Louis, MO, United States;
4 Psychology, Washington University in St. Louis, St. Louis, United States; 5 Neurology, Washingotn University
in St. Louis, St. Louis, MO, United States
This project investigated early biomarkers of Alzheimer’s disease (AD). In particular, we studied the relationship between
psychometrics (the Stroop task) and blood oxygen level dependent resting state functional connectivity magnetic resonance imaging
(BOLD-fcMRI). We observed significant differences in BOLD-fcMRI correlations between subjects with high and low COV subjects
within the default mode network (DMN). Our results suggest that psychometric changes are associated with alterations in the DMN
with both being early markers for individuals at risk for AD.
14:30 4248. Structural and White Matter Changes in Patients with Dementia: Comparative
FDG-PET and MRI Studies
Elena Gerasimovitch Steffensen 1 , Vineet Prakash 2 , Simon Fristed Eskildsen 3 , Karsten
Vestergård 4 , Victor Vishwanath Iyer 2 , Elna-Marie Larsson 5
1 Department of Radiology, Aalborg Hospital/Århus University Hospital, Aalborg, Denmark; 2 Department of
Nuclear Medicine, Aalborg Hospital/Århus University Hospital, Aalborg, Denmark; 3 Department of Health
Science and Technology, Aalborg University, Aalborg, Denmark; 4 Department of Neurology, Aalborg
Hospital/Århus University Hospital, Aalborg, Denmark; 5 Department of Radiology, Uppsala University
Hospital, Uppsala, Sweden
Introduction: Volumetry and evaluation of WM damage is used to characterization of dementia. Purpose: To investigate whether
cortical/hippocampal volumetry; measurement of mI- and NAA-concentration or FA and ADC is preferable in classification of
dementia. Method: 3T protocol: 3D T1-weighted imaging; 1H-spectroscopy and DTI in 34 patients. 18FDG-PET: 9 FTD patients; 9-
AD, 2- normal PET. Results: Thinner cortex and higher ratio of mI/NAA was seen in posterior cingulate cortex (PCC) for AD
(p