ELECTRONIC POSTER - ismrm

Wednesday 13:30-15:30 Computer 84
13:30 4446. Imaging at 7T Reveals New Septated Fine Structure in the Human Corpus
Callosum
Chris Wiggins 1 , Andreas Schaefer 2 , Bibek Dhital 2 , Denis Le Bihan 1 , Robert Turner 2
1 CEA NeuroSpin, Gif-sur-Yvette, France; 2 Max Planck Institute for Human Cognitive and Brain Sciences,
Leipzig, Germany
At 7 T, high resolution structural imaging shows fine details of brain structures in vivo. Examining such images of the adult human
corpus callosum, we have discovered two-dimensional planar structures never previously described with traditional histological
techniques. Analysis of good quality DTI data at 3T supports this observation, showing a second preferred direction of water
diffusion. Interhemispheric axonal connections show detailed laminar ordering at submillimeter scale.
14:00 4447. Magnetic Resonance Imaging of Cranial Nerves at 7 Tesla
Astrid Ellen Grams 1,2 , Oliver Kraff, 1,2 , Stephan Orzada, 1,2 , Stefan Maderwald, 1,2 , Janine
Kalkmann 1 , Mark E. Ladd, 1,2 , Michael Forsting 1 , Elke Ruth Gizewski 1,2
1 Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen,
NRW, Germany; 2 Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Hospital Essen, Essen,
NRW, Germany
In the present study the feasibility of cranial nerve imaging with a 7 Tesla whole body scanner was investigated. For this purpose four
sequences were evaluated. A 3D-TrueFISP sequence allowed the best cranial nerve detection rate in a reasonable scan time. This
sequence seems to be superior at the moment as in the 3D-CISS, the “gold standard” sequence at lower magnetic field strengths, no
parallel imaging could be performed.
14:30 4448. Imaging of the Inner Ear at 7T: Initial Results
Taro Takahara 1 , Hans Hoogduin 1 , Fredy Vissor 1 , Shinji Naganawa 2 , Thomas Kwee 1 ,
Peter Luijten 1
1 Radiology, University Medical Center Utrecht, Utrecht, Netherlands; 2 Radiology, Nagoya Univeristy, Nagoya,
Aichi, Japan
To our knowledge, this is the first time the inner ear was imaged at 7T using a 3D-turbo spin echo sequence. Although not all parts of
the inner ear could be visualized well due to inhomogeneities, our results are promising and may have a positive impact for future
(MR) studies of cochlear implants. Improvement in B1 shimming and dedicated RF pulses are expected to further improve image
quality.
15:00 4449. Anatomical Phenotyping of Cerebellum and Vestibulo-Cochlear Organ in Mice
Using Contrast Enhanced Micro-MRI
Kamila Urszula Szulc 1 , Edward Joseph Houston 1 , Roy V. Sillitoe 2 , Alexandra L. Joyner 3 ,
Daniel H. Turnbull 1,4
1 Skirball Institute, NYU School of Medicine, New York, NY, United States; 2 Neuroscience, Albert Einstein
College of Medicine, New York, NY, United States; 3 Developmental Biology Program, Sloan-Kettering
Institute, New York, NY; 4 Radiology, NYU School of Medicine, New York, NY, United States
In this study we demonstrate a potential of contrast enhanced micro-MRI approach for simultaneous anatomical phenotyping of the
cerebellum and the vestibulo-cochlear organ in wild type mice and Gbx2-CKO mutant mice, which have severe defects in the Cb in
the form of deletion of its central part. Additionally, these mice display abnormalities in the anatomy of flocculus-paraflocculus
complex, a region of the Cb that receives projections from the vestibular organs and is critical for normal vestibular function. It was
therefore of interest to determine whether the Cb defects were accompanied by additional, previously overlooked abnormalities in the
vestibulo-cochlear organ.
Thursday 13:30-15:30 Computer 84
13:30 4450. The Reproducibility of Phase and R 2 * Acquired with Multi Echo Susceptibility
Weighted Imaging
Christian Denk 1 , Alexander Rauscher 1
1 UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada
Due to their high sensitivity to changes in iron content, phase images and maps of R2* relaxation obtained with gradient echo
techniques have been gaining popularity in the imaging of neurodegenerative diseases. However, the reproducibility of these
techniques has not been investigated yet. Therefore, we determined the reproducibility of phase and R2* maps acquired with multi
echo susceptibility weighted imaging and found that the intersession coefficient of variation is much smaller in phase images than in
R2* maps.