ELECTRONIC POSTER - ismrm

lipoatrophy with decreased of the lean mass after switching the treatment, and it was related with IMCL decreased, although no
significant. A probable migration of lipid content from intramyocellular to periphery can explain partially the peripheral fat gain and
loss of peripheral lean mass, although other factors may participate.
15:00 3239. Assessment of Acetylcarnitine in Individuals with Type 1 Diabetes After Exercise in
Eu- And Hyperglycemia Using 1 H MR Spectroscopy in Skeletal Muscle
Andreas Boss 1 , Christoph Stettler 2,3 , Michael Ith 1,4 , Stefan Jenni 2,5 , Chris Boesch 1 ,
Roland Kreis 1
1 Department of Clinical Research, University of Bern, Bern, Switzerland; 2 Division of Endocrinology, Diabetes
and Clinical Nutrition, Inselspital, Bern, University Hospital and University of Bern, Bern, Switzerland;
3 Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland; 4 Institute for Diagnostic,
Interventional and Pediatric Radiology, University Hospital and University of Bern, Bern, Switzerland;
5 International Center for Circulatory Health, Imperial College, London, Switzerland
Differences in the exercise-induced production of acetylcarnitine, a buffer of acetyl-CoA, in eu- vs. hyperglycaemia have been
analyzed by 1H-MR spectroscopy in thigh muscle. Spectra were obtained before and after exercise (120min. at 55 to 60% VO2max,
with indirect calorimetry) in 7 physically active type 1 diabetic males. During both trials, insulinaemia was kept constant and the
contribution of the various substrates was determined. Acetylcarnitine was elevated 1h after exercise (p