ELECTRONIC POSTER - ismrm

15:00 3471. Laminar-Specific Output- To Input-Layer Connections Between Cortical Areas V1
and MT Observed with High-Resolution Resting-State FMRI
Jonathan Rizzo Polimeni 1 , Bruce Fischl 1,2 , Douglas N. Greve 1 , Lawrence L. Wald 1,3
1 Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School,
Massachusetts General Hospital, Charlestown, MA, United States; 2 Computer Science and AI Lab (CSAIL),
Massachusetts Institute of Technology, Cambridge, MA, United States; 3 Harvard-MIT Division of Health
Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States
In this study, we demonstrate a laminar-specific BOLD response using resting state measurements of functional connectivity within
visual cortex by exploiting the known anatomical connectivity pattern between output Layer II/III in cortical area V1 and input Layer
IV in area MT observed by invasive studies. This laminar correlation signature was absent from cross-hemispheric laminar
correlations measured between left and right V1. These V1-to-MT laminar-specific resting state correlations demonstrate the ability of
high-resolution rs-fMRI to probe laminar-specific connections and to infer the directionality of the connectivity, and provide evidence
that the BOLD signal is controlled, to some degree, on the laminar level.
fMRI Quantitation/Calibration
Hall B Monday 14:00-16:00 Computer 23
14:00 3472. Combined Interactions of Respiratory and Cardiac Signals Measured by High-
Temporal Resolution FMRI
Pierre LeVan 1 , Thimo Grotz 1 , Benjamin Zahneisen 1 , Maxim Zaitsev 1 , Juergen Hennig 1
1 Medical Physics, University Hospital Freiburg, Freiburg, Germany
This study investigates the effect of respiratory and cardiac artifacts in the fMRI signal using very high-temporal resolution
acquisitions (TR=80ms). It is shown that high-order harmonics of the respiratory (up to order 5) and cardiac (up to order 10) signals
account for widespread, statistically significant effects in the fMRI signal (p