ELECTRONIC POSTER - ismrm

15:00 4071. A Comparison of 3D-GRASE and EPI for Vessel-Encoded Arterial Spin Labeling
Thomas William Okell 1,2 , Michael Chappell 1 , Matthias Günther 3,4 , Peter Jezzard 1
1 FMRIB Centre, Clinical Neurology, University of Oxford, Oxford, Oxfordshire, United Kingdom;
2 Department of Medical Physics and Clinical Engineering, Oxford Radcliffe Hospitals NHS Trust, Oxford,
Oxfordshire, United Kingdom; 3 Faculty for Physics and Electrical Engineering, University Bremen, Bremen,
Germany; 4 Fraunhofer MEVIS-Institute for Medical Image Computing, Bremen, Germany
In this study we compare echo planar imaging (EPI) and 3D-GRadient and Spin Echo (3D-GRASE) readouts with a vessel encoded
arterial spin labelling preparation. Comparable vascular territory maps were obtained in both cases. The 3D-GRASE images had
twice the signal-to-noise ratio and reduced signal drop-out but suffered from some blurring in the slice direction despite the use of
parallel acceleration in one dimension. We conclude that 3D-GRASE is a viable option for vascular territory imaging but would be
improved by reduced blurring which could be achieved by using parallel acceleration in two dimensions, for example.
ASL: Applications & Reproducibility
Hall B Monday 14:00-16:00 Computer 61
14:00 4072. Cerebral Autoregulation Impairment Measured at the Brain Tissue Level with
Arterial Spin Labeling MRI in Patients with a Symptomatic Carotid Artery Stenosis
Reinoud Pieter Harmen Bokkers 1 , Matthias J.P. van Osch 2 , H Bart van der Worp 3 , Gert
J. de Borst 4 , Willem P Th M Mali 1 , Jeroen Hendrikse 1
1 Department of Radiology, UMCU, Utrecht, Netherlands; 2 Department of Radiology, LUMC, Leiden,
Netherlands; 3 Department of Neurology, UMCU, Utrecht, Netherlands; 4 Department of Vascular Surgery,
UMCU, Utrecht, Netherlands
Patients with a stenosis of the internal carotid artery have a high risk of ischemic stroke. In these patients, impairment of the
vasodilatory capacity of the cerebral vasculature is an important measure of the degree of hemodynamic compromise. The aim of our
study was to measure the cerebral autoregulatory status of the brain tissue supplied by the individual brain feeding arteries using
arterial spin labeling MRI and to compare this to healthy controls. Our results show, that ASL is able to visualize and quantify the
vasodilatory capacity in the flow territories of the major cerebral arteries at brain tissue level.
14:30 4073. High Flavonoid Cocoa Changes Regional Cerebral Blood Flow
Laura M. Parkes 1,2 , Jonathan A. Goodwin 2 , Andrew Irwin 2 , Roeland van Kerckhoven 3 ,
Richard Draijer 3
1 Imaging Sciences, University of Manchester, Manchester, United Kingdom; 2 MARIARC, University of
Liverpool, Liverpool, United Kingdom; 3 Unilever Research & Development, Vlaardingen, Netherlands
The aim was to investigate the effect of high-flavonoid cocoa on CBF in a group of 15 subjects using arterial spin labeling, and
determine any link between CBF and cognitive performance. We used a randomized cross-over design with 2 treatments: Cocoa soydrink
and a placebo drink, each taken for two weeks with CBF and cognitive performance measured at the end of each period.
Consumption of high-flavonoid cocoa increased CBF in the temporal lobe and hippocampal regions involved in long-term memory
function and decreased CBF to regions involved in working memory, in agreement with cognitive results.
15:00 4074. Resting Cerebral Blood Flow as a Biomarker of HIV in the Brain
Jewell Thomas 1 , Huiling Peng 1 , Tammie Benzinger 2 , Avi Snyder 1 , David Clifford 1 , Beau
Ances 1
1 Neurology, Washington University in St. Louis, St. Louis, MO, United States; 2 Radiology, Washington
University in St. Louis, St. Louis, MO, United States
HIV causes hypoperfusion within cortical and subcortical brain structures. We used arterial spin labeling (ASL) to measure resting
cerebral blood flow (rCBF) within HIV+ participants (both naïve and on stable highly active antiretroviral therapy (HAART)) and
HIV- controls. HIV- controls had a significantly higher rCBF (61.7 ± 1.7 mL/100gm/min) compared to HIV+ participants (48.4 ± 1.9
mL/100gm/min). rCBF was significantly diminished in HIV+ naïve patients (44.8 ± 1.9 mL/100gm/min) compared to HIV+ subjects
on stable HAART (52.6 ± 2.0 mL/100gm/min). Our results suggest that rCBF may provide a sensitive biomarker for efficacy of
HAART in the brain of HIV+ participants.
15:30 4075. Hemodynamic Characterization of Dementias Via Pseudo Continuous ASL
Simone Chaudhary 1,2 , Rafal Janik 1 , Amy Scouten 1 , Adrienne Dorr 1 , Wayne Lee 3 , Graeme
Schwindt 1 , Sandra Black 1 , John Sled 3 , Bojana Stefanovic 1
1 Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; 2 Medical Biophysics, University of Toronto,
Toronto, Ontario, Canada; 3 Hospital for Sick Children, Toronto, Ontario, Canada
A number of neurodegenerative diseases are characterized by compromised cerebral hemodynamics. Cerebral blood flow (CBF) and
arterial transit time have been mapped in healthy elderly, MCI, and AD via pulsed continuous ASL at varying inversion times. Two
compartment theory was employed in the analysis. MCI showed a trend toward decreased CBF relative to healthy volunteers, whereas
AD was associated with a pronounced, statistically significant hypoperfusion. Arterial transit time decreases suggested compensatory
vasodilation in a subset of subjects.