ELECTRONIC POSTER - ismrm

were observed from the preCG and IC from both the hemispheres. Significantly higher Cho/Cr ratios were also observed from the
preCG, postCG and IC regions indicating that metabolic abnormalities in ALS extend beyond the motor cortex that can be observed
using EPSI.
14:30 4259. Study on Gray and White Matter Changes in ALS with Voxle-Based Morphometry
Using DARTEL
Lin Ma 1 , Zhiye Chen 1
1 Department of Radiology, PLA General Hospital, Beijing, China
Standard VBM (VBM-STANDARD) has demonstrated gray and white matter loss in ALS. In order to evaluate the efficacy of VBM
with DARTEL algorithm (VBM-DARTEL), both VBM-DARTEL and VBM-STANDARD were performed in ALS. High resolution
images were acquired from 30 ALS patients and 30 controls. ALS was subclassified into ALS/MCI and ALS/CN, and ALS/Bulbar
and ALS/Limb. VBM-DARTEL revealed more gray and white matter deficits than VBM-STANDARD. With VBM-DARTEL, gray
matter loss was also detected in ALS/MCI compared with ALS/CN, and gray and white matter deficits in ALS/Limb compared with
ALS/Bulbar. VBM-DARTEL was more accurate than VBM-STANDARD in performing volumetric studies.
15:00 4260. Whole-Brain Proton MRSI in ALS: Changes in the Distribution of Metabolites by
Brain Lobes and Tissue Types
Varan Govind 1 , Khema R. Sharma 2 , Sulaiman Sheriff 1 , Andrew A. Maudsley 1
1 Radiology, University of Miami, Miami, FL, United States; 2 Neurology, University of Miami, Miami, FL,
United States
Whole-brain proton MRSI data acquired at 3T from groups of definite-ALS and control subjects were analyzed by brain hemispheric
lobes and parenchymal constituent tissue-types (white matter and gray matter). The metabolite ratios, NAA/Cr and Cho/NAA, in the
white matter showed significant and widespread alterations throughout the brain of ALS patients. In the gray matter of the ALS group,
significant differences were found in the left frontal- and left parietal lobes for NAA/Cr, and bilateral frontal lobe for Cho/NAA.
15:30 4261. Brain DT MRI Predicts the Long-Term Clinical Evolution in Amyotrophic Lateral
Sclerosis: A 3.4 Year Follow Up Study
Federica Agosta 1 , Elisabetta Pagani 1 , Melissa Petrolini 1 , Maria Pia Sormani 2 , Domenico
Caputo 3 , Michele Perini 4 , Alessandro Prelle 5 , Fabrizio Salvi 6 , Massimo Filippi 1
1 Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific
Institute and University Hospital San Raffaele, Milan, Italy; 2 Unit of Biostatistics, DISSAL, University of
Genoa, Genoa, Italy; 3 Department of Neurology, Scientific Institute Fondazione Don Gnocchi, Milan, Italy;
4 Department of Neurology, Ospedale di Gallarate, Gallarate, Italy; 5 Dino Ferrari Center, Department of
Neuroscience, University of Milan, Milan, Italy; 6 Department of Neurology, Ospedale di Bellaria, University of
Bologna, Bologna, Italy
We investigated whether corticospinal tract (CST) DT-MRI changes contribute to the prediction of long-term clinical evolution in
patients with amyotrophic laterals sclerosis (ALS). Conventional and DT-MRI were obtained in 24 ALS patients, who were followed
prospectively for 3.4 years. Compared with controls, ALS patients showed increased MD and decreased FA of the CST. Shorter
disease duration and lower CST FA were associated with disability worsening. Bulbar-onset and CST FA were independent predictors
of time to death in ALS patients. More severe DT-MRI abnormalities in the CST predicted a poorer clinical outcome after a 3.4 year
follow up in ALS patients.
Tuesday 13:30-15:30 Computer 73
13:30 4262. Altered Functional Connectivity of the Motor Network in Multiple System Atrophy
Feng Feng 1 , Hui You 1 , Han Wang 2 , Fuling Zheng 1 , Chunling Meng 1 , Jue Wang 3 , Yufeng
Zang 3
1 Radiology, Peking Union Medical College Hospital, Beijing, China; 2 Neurology, Peking Union Medical
College Hospital, Beijing, China; 3 State Key Laboratory of Cognitive Neuroscience and Learning, Beijing
Normal University, Beijing, China
MSA is mainly a sporadic neurodegenerative disease. Besides abnormalities of nigrostriatal pathway, the typical pathological findings
were also described in primary motor and supplementary motor cortices. We hypothesize that there is associated disturbance of
functional connectivity of the motor cortex in MSA patients. To test the hypothesis, resting-state functional MRI was used to measure
the coherent spontaneous fluctuations in the blood oxygenation level¨Cdependent signal. Our results showed regional homogeneity
changes in left precentral gyrus, right precuneus, supramarginal gyrus and middle frontal gyrus, indicating functional connectivity
disturbance of motor-related circuits and left-sided predominance of primary motor cortex involvement.