ELECTRONIC POSTER - ismrm

14:00 3253. High Resolution MRI of the Plantar Plates in Patients with Rheumatoid Arthritis
Heidi J. Siddle 1 , Andrew J. Grainger 2 , Anthony C. Redmond 1 , Philip S. Helliwell 1 ,
Richard J. Wakefield 1 , Richard J. Hodgson 3
1 Section of Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; 2 Department of Radiology,
Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom; 3 Leeds Musculoskeletal Biomedical Research
Unit, University of Leeds, Leeds, United Kingdom
Damage to the plantar plates of the metatarsophalangeal joints has been suggested as a cause of forefoot pain and deformity in patients
with rheumatoid arthritis (RA). This study looked at 68 plantar plates in patients with RA and forefoot pain using high resolution 3T
MRI. Plantar plate pathology was revealed in all patients. However, high signal at the insertion on T2-weighted images (often
interpreted as a tear) is not indicative of a tear in patients with RA.
14:30 3254. Dynamic Contrast Enhanced MRI of Bone Marrow in Rheumatoid Arthritis and
the Response to Treatment.
David A. King 1 , Edward M. Vital 1 , Jane E. Freeston 1 , Philip O'Connor 2 , Robert Evans,
2,3 , Peter Wright, 2,3 , Paul Emery 1 , Richard Hodgson, 1,3
1 University of Leeds, Leeds, Yorkshire, United Kingdom; 2 Chapel Allerton Hospital, Leeds, United Kingdom;
3 Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom
This study uses dynamic contrast enhanced MRI to study the response of bone marrow to therapy. 30 patients with long-standing,
active rheumatoid arthritis were imaged before and at 12 and 24 weeks after starting biologic treatment. 3D SPGR images of the wrist
were acquired every 19 seconds and the relative early enhancement rate of bone marrow calculated from a carpal bone. There was a
statistically significant decrease in the RER at both 12 and 24 weeks after starting treatment. This suggests DCE-MRI of bone marrow
may be useful for assessing the response to treatment in rheumatoid arthritis.
15:00 3255. The Value of Dce-Mri in the Differential Diagnosis of Psoriatic Arthritis and
Erosive Osteoarthritis of the Hand
Christina Schraml 1 , Nina F. Schwenzer 1 , Ina Kötter 2 , Jörg C. Henes 2 , Fritz Schick 3 ,
Claus D. Claussen 1 , Marius Horger 1
1 Department of Diagnostic and Interventional Radiology, University Hospital of Tübingen, Tübingen, BW,
Germany; 2 Department of Internal Medicine II, University Hospital of Tübingen, Tübingen, BW, Germany;
3 Section on Experimental Radiology, University Hospital of Tübignen, Tübingen, BW, Germany
In the present 3T study, DCE-MRI was evaluated in the differential diagnosis of psoriatic arthritis (PsA) and erosive arthritis (EOA)
of the hand in 26 patients. Significantly higher late enhancement was observed in EOA patients 15 minutes after contrast injection.
Results suggest that analysis of synovial membrane inflammation by DCE-MRI could be useful in the differentiation of these two
arthritis types which is often difficult based on clinical and laboratory findings alone. As new treatment approaches are particularly
adapted for each arthritis entity DCE-MRI could provide additional diagnostic information in differentiating PsA from EOA in clinical
routine.
Thursday 13:30-15:30 Computer 6
13:30 3256. Improving Isotropic 3D FSE Methods for Imaging the Knee
Charles Qingchuan Li 1 , Weitian Chen 2 , Jarrett K. Rosenberg 1 , Philip J. Beatty 2 , Anja C.
Brau 2 , Richard X. Kijowski 3 , Brian A. Hargreaves 1 , Reed F. Busse 4 , Garry E. Gold 1
1 Radiology, Stanford University, Stanford, CA, United States; 2 Global Applied Science Laboratory, GE
Healthcare, Menlo Park, CA, United States; 3 Radiology, University of Wisconsin, Madison, WI, United States;
4 Global Applied Science Laboratory, GE Healthcare, Madison, WI, United States
A new isotropic 3D FSE sequence, 3D-FSE-Cube, is currently being developed for multiple structural imaging applications as an
improvement to traditional 2D-FSE methods. This study aimed to optimize 3D-FSE-Cube for musculoskeletal evaluation of the knee
at 3T. 146 scans from 7 healthy volunteers were acquired with systematically varied acquisition parameters and evaluated for SNR,
CNR and image quality in comparison to a single reference standard. Regression analysis suggests that current clinical acquisition
parameters produce close to optimal image quality.
14:00 3257. 3D-Imaging of the Knee with an Optimized 3D-TSE Sequence and a 15 Channel
Knee-Coil at 3T
Mike Notohamiprodjo 1 , Annie Horng 2 , Bernhard Kuschel 2 , Peter Bär 3 , Maximilian F.
Reiser, Christian Glaser
1 Institute for Clinical Radiology, University Hospitals Munich, Munich, Bavaria, Germany; 2 University
Hospitals Munich, Insitute for Clinical Radiology; 3 Siemens Sector Healthcare
The purpose of this study was to evaluate a 3D-TSE-sequence with optimized acquisition strategies for improved tissue-contrast.
Fifteen volunteers and 50 patients were examined at 3T (Magnetom VERIO, Siemens Sector Healtcare) with the PDfs-weighted 3D-
TSE-sequence SPACE. Relevant SNR and CNR, i.e. fluid and Cartilage, of the isotropic 3D-TSE-sequence were significantly higher
than of conventional 2D-TSE-sequences. Depiction of the femoral trochlea and small structures was significantly better. Small lesions
could be better detected with the 3D-TSE-sequence. Diagnostic confidence was not significantly different. This technique hold high
potential for further knee-MRI-protocols with excellent image quality and clinical performance compared to current 2D-protocols.