ELECTRONIC POSTER - ismrm

14:00 4451. Vessel Contrast in Susceptibility Weigthed Imaging (SWI) Under Inhalated
Anesthesia with Different Oxygen Pressure
Marina Benito 1 , Alexia Rodríguez-Ruano 2 , Cristina Chavarrias 1 , Paula Montesinos 1 ,
Manuel Desco 1
1 Unidad de Medicina y Cirugía Experimental, Hospital General Universitario Gregorio Marañón, Madrid,
Spain; 2 Unidad de Medicina y Cirugía Experimental , Hospital General Universitario Gregorio Marañón,
Madrid, Spain
SWI allows to delineate the cerebral veins in high quality, however during the MRI exam animals are anaesthetized. Anesthetics
make vary the venous contrast depending on the deepness of anesthesia, but when using inhalated anesthesia the venous response on
SWI also depends on the partial pressure of oxygen (pO2) in the supplied gas. This study investigates how the pressure of oxygen in
the supplied gas affects the venous contrast in SWI in order to study the microvasculature of the rat brain.
14:30 4452. Detection of Cerebral Microbleeds with Dual Echo T2*-Weighted MR Imaging at
7.0 Tesla
Mandy Conijn 1 , Mirjam Geerlings, Peter Luijten, Jaco Zwanenburg, Jeroen Hendrikse
1 Radiology, University Medical Center Utrecht, Utrecht, Netherlands
The interest in microbleeds is increasing, however, prevalence estimates differ substantially between studies, due to differences in
image protocols and field strengths. This study assessed the visualization of cerebral microbleeds with dual-echo T2*-weighted
imaging at 7T MRI in ten patients with vascular disease. The first echo images showed a large contrast between microbleeds and the
surrounding tissue. On the second echo images microbleeds were larger in size, but some were not visible due to overlap with
structures with a high susceptibility. Dual-echo T2*-weighted imaging combines the advantages of the first and second echo time for
the visualization of microbleeds at 7T.
15:00 4453. High Spatiotemporal Resolution Whole Brain Susceptibility Weighted Imaging
Using Parallel Imaging
Song Lai 1 , John Lackey 1
1 Radiology, Thomas Jefferson University, Philadelphia, PA, United States
Parallel imaging was explored for speeding up data acquisition of susceptibility-weighted imaging (SWI). Combination of SENSE
with segmented EPI lead to sub-minute data acquisition with whole brain coverage and 1mmx1mmx1mm isotropic voxels, making
SWI a completely clinically applicable technique for many applications.
fMRI in Brain Disorders
Hall B Monday 14:00-16:00 Computer 85
14:00 4454. Compensatory Mechanisms During Motor Sequence Learning in Parkinson’s
Disease. a FMRI Study.
Maite Aznarez-Sanado 1 , Maria Asuncion Fernandez-Seara 1 , Federico Villagra 1 , Francis
R. Loayza 1 , Jaione Irigoyen 1 , Gonzalo Arrondo 1 , Elena Erro 2 , Maria Asuncion Pastor 1
1 Neuroscience, Center for Applied Medical Research. University of Navarra, Pamplona, Navarra, Spain;
2 Servicio de Neurología, Hospital de Navarra, Pamplona, Navarra
We aimed to study using fMRI differences in neural patterns during motor sequence learning and automatic performance in
Parkinson’s disease (PD) patients. The comparison of the early learning phase in the PD group with the control group revealed
increased activity in cortical and cerebellar areas and right putamen in the PD group. The most affected hand recruited contralateral
basal ganglia more significantly than the non affected hand in the PD group.
14:30 4455. Differential Brain Activation Pattern for a Simple Motor Task in Parkinsonism: An
FMRI Study
Mohit Saxena 1 , Senthil S. Kumaran 2 , Sumit Singh 1 , Madhuri Behari 1
1 Department of Neurology, All India Institute of Medical Sciences, New Delhi, India; 2 Department of N.M.R.,
All India Institute of Medical Sciences, New Delhi, Delhi, India
Parkinsonism including Parkinson’s disease, multiple system atrophy and progressive supranuclear palsy, is characterized by motor
dysfunction. In this fMRI study, we observed differential activation pattern among the above three categories. Also, motor dysfunction
improved with the intake of dopaminergic drugs.