ELECTRONIC POSTER - ismrm

15:00 4589. Assessment of Liver Oxygenation with BOLD MRI at 3T. Feasibility Study
Peter Beddy 1 , Richard Black 1 , Lorenzo Mannelli 2 , Ilsa Joubert 1 , Andrew Priest 1 , David J.
Lomas 1
1 Radiology, University of Cambridge and Addenbrookes Hospital, Cambridge, Cambridgeshire, United
Kingdom; 2 Radiology, University of Cambridge and Addenbrookes Hospital, Cambridge, Cambridgeshire,
United Kingdom
BOLD MRI is a potential non-invasive method for assessing tissue oxygenation in a wide range of tissues. This work develops a
method for oxygen challenge based BOLD imaging of the liver at 3T in a group of volunteers and demonstrates that acceptable results
and low variability can be achieved using both breath-hold and respiratory triggered multi-echo gradient echo acquisitions.
Wednesday 13:30-15:30 Computer 93
13:30 4590. Alteration in the Conjugation Pattern of Bile Acids in Human Bile During
Cholestasis: A 1 H MRS Study
Tedros Bezabeh 1 , Omkar B. Ijare 1 , Nils Albiin 2 , Annika Bergquist 3 , Urban Arnelo 4 ,
Matthias Löhr 3 , Johannes R. Hov 5 , Ian CP Smith 1
1 National Research Council Institute for Biodiagnostics, Winnipeg, Manitoba, Canada; 2 Radiology, Karolinska
Institutet, Stockholm, Sweden; 3 Gastroenterology and Hepatology, Karolinska Institutet, Stockholm, Sweden;
4 Surgery, Karolinska Institutet, Stockholm, Sweden; 5 Medicine, Oslo University Hospital Rikshospitalet, Oslo,
Norway
Conjugation of bile acids with amino acids glycine and taurine is an important phenomenon in bile formation. In healthy humans, the
ratio of glycine- to taurine-conjugated bile acids is generally 3:1, and this ratio is altered in cholestatic conditions. We analyzed bile
samples from patients with various cholestatic diseases and found that the median of the above ratio was 2.23:1. This alteration could
be attributed to the elevation in the levels of taurine-conjugates or reduction in the levels of glycine-conjugates. Such alterations can
be easily detected by 1 H MRS and the technique could be valuable in the diagnosis of diseases related to bile acid synthetic defects.
14:00 4591. Are Dynamic First-Pass Enhancement Properties of Gadoxetic Acid (Gd-EOB-
DTPA) Comparable to Gadopentetate Dimeglumine (Gd-DTPA) in Hepatocellular
Carcinoma (HCC)?
Mi-Suk Park 1 , Myeong-Jin Kim 2 , Ki Whang Kim 1
1 Department of Diagnostic Radiology, Yonsei University Health System Severance Hospital, Seoul, Korea,
Republic of; 2 Severance hospital
In this abstract, we compared dynamic first-pass enhancement properties of gadoxetic acid with that of gadopentetate dimeglumine in
the patients with HCC. Gadoxetic acid-enhanced MRI showed more rapid wash-out of HCC, stronger enhancement of hepatic
parenchyma, and weaker enhancement of vessels than the standard Gd-chelate enhanced MRI.
14:30 4592. Diffusion-Weighted Imaging: Diagnostic Value in the Assessment of Intrahepatic
Metastases of Hepatocellular Carcinoma
Jeong-Sik Yu 1 , Jae-Joon Chung, Joo Hee Kim, Ki Whang Kim
1 Radiology, Gangnam Severance Hospital, Seoul, Korea, Republic of
For the hepatocellular carcinomas, the presence of small satellite lesions is an important determinant of a patient¡¯s prognosis and
therapeutic planning. Through the results of our study DWI is superior to dynamic MRI in the detection and characterization of
subcentimeter lesions and can be added to strengthen the accuracy in the MRI assessment of intrahepatic metastases of HCCs. DWI
could overcome the inherent drawbacks of dynamic MRI for the hypervascular pseudolesions or obscured tumoral vascularities by the
perfusional changes in the background parenchyma serve as a complementary tool for patients examined by dynamic MRI.
15:00 4593. Gd-EOB-DTPA Combined with Gd-DTPA: Hepatobiliary Contrast with Familiar
Hepatic Dynamic Contrast Enhancement
Jesse L. Wei 1,2 , Kimiknu Mentore 1 , Martin P. Smith 1,2 , Neil M. Rofsky 1,2
1 Radiology, Beth Israel Deaconess Medical Center, Boston, MA, United States; 2 Harvard Medical School,
Boston, MA, United States
Administration of Gd-EOB-DTPA using the recommended dose for hepatobiliary imaging results in an unfamiliar "washed out"
appearance of the liver on dynamic contrast enhanced (DCE) imaging. This likely results from increased background hepatic
enhancement due to early hepatobiliary uptake. Injection of a combination of Gd-EOB-DTPA in conjunction with an extracellular
contrast agent provides the 20-minute delayed hepatobiliary phase, while preserving the familiar vascular contrast and lesion
conspicuity compared to background liver on DCE images.