ELECTRONIC POSTER - ismrm

hyperpolarized for use as a metabolic probe, providing the potential to measure changes in carbohydrate metabolism that occur with
human disease.
14:30 3286.
19 F-MRI Using Hyperpolarized Substrates and Field Cycling
Thomas Trantzschel 1 , Ute Bommerich 2 , Joachim Bargon 3 , Johannes Bernarding 1
1 Dept. of Biometrics and Medical Informatics, Otto-von-Guericke-University, Magdeburg, Germany; 2 Leibniz
Institute for Neurobiology, Magdeburg, Germany; 3 Institute of Physical and Theoretical Chemistry, University
of Bonn, Bonn, Germany
The lack of natural background signal in body tissues qualifies fluorinated substrates as excellent reporter molecules for MRI and
MRS investigations. As a further advantage many pharmaceuticals contain 19 F allowing for detection of pharmacokinetics and
metabolism as well as to investigate anatomical and physiological features, e.g. lung volume. However, due to the restricted in vivo
substrate concentration the 19 F-signals often remain weak. To overcome these restrictions we enhanced the 19 F signal via
ParaHydrogen Induced Polarization. Additionally, we increased the efficiency of the spin polarization transfer to this nucleus by
applying a field cycling procedure which improves the SNR in 19 F-MRI.
15:00 3287. Parallel MRI Acceleration of Dynamic and High Resolution Hyperpolarized 13 C
MRI
Lanette Friesen Waldner 1,2 , Jian X. Wang 3 , Albert Chen 4 , Alexei Oriadov 1 , Matthew
Fox 1,5 , Brian Rutt, 1,6 , Timothy Scholl 5 , Giles Santyr 1,7 , Charles McKenzie, 12
1 Imaging Research Laboratories, Robarts Research Institute, London, ON, Canada; 2 Medical Biophysics, The
University of Western Ontario, London, ON, Canada; 3 Global Applied Science Laboratory, GE Healthcare,
London, ON, Canada; 4 GE Healthcare, Toronto, ON, Canada; 5 Physics and Astronomy, The University of
Western Ontario, London, ON, Canada; 6 Diagnostic Radiology and Richard M Lucas Center for Imaging,
Stanford University, Stanford, CA, United States; 7 Medical Imaging, The University of Western Ontario,
London, ON, Canada
Imaging with hyperpolarized agents requires extremely fast imaging techniques as the hyperpolarized state only lasts for tens of
seconds. Parallel MRI reduces image encoding time, allowing hyperpolarized images to be acquired faster, or at higher spatial
resolution than would otherwise be possible. Using a custom eight-element 13 C array to acquire images of a rat following injection of
hyperpolarized 13 C enriched pyruvic acid, we demonstrate accelerated imaging, using self calibrated PMRI to achieve high spatial and
temporal resolutions. These results represent the first hyperpolarized 13 C PMRI experiments conducted with a receive array with more
than 4 elements.
Thursday 13:30-15:30 Computer 8
13:30 3288. The Metabolic Effects of Pyruvate Infusion During Hyperpolarized Magnetic
Resonance Experiments
Helen Jennifer Atherton 1 , Michael S. Dodd 1 , Emma E. Carter 1 , Marie A. Schroeder 1 ,
Simon Nagel 2 , Nicola R. Sibson 3 , Kieran Clarke 1 , George K. Radda 1 , Damian J. Tyler 1
1 Physiology, Anatomy and Genetics, University of Oxford, Oxford, Oxfordshire, United Kingdom; 2 Nuffield
Department of Clinical Medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom; 3 CRUK-MRC
Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford, Oxfordshire, United
Kingdom
Hyperpolarized 13C-magnetic resonance spectroscopy (MRS) represents a powerful technique for studying metabolism in vivo. To
assess pyruvate metabolism in rats, 1ml 80mM [1-13C]pyruvate is injected. This study investigated the metabolic effects of injecting
supraphysiological pyruvate concentrations and found that circulating pyruvate concentration peaked 1min post infusion at ~250µM,
equivalent to levels reached naturally within the body e.g. during exercise. The plasma concentration of glucose, insulin,
triacylglycerides and NEFAs did not alter significantly up to 30min post infusion, however lactate and beta-hydroxybutyrate levels
increased significantly 30min post infusion (p