ELECTRONIC POSTER - ismrm

measure is available for motor behavior of manganese exposure in vivo. The aim of this study investigates motor behavior of
manganese exposure compared to normal group using simple motor task. Compared to normal controls, the welder groups showed
widespread activations in the supplementary motor area, cingulate motor areas and bilaterally increased activation in the parietal lobe
and frontal lobe. This observation suggests the change of motor network in response to Mn accumulation. Therefore, motor fMRI is
quite sensitive measure to change of motor network of Mn exposed brain even without T1 high signal at GP and has a great potential
as functional diagnostic tool of damaged motor system in occupational exposure to Mn.
14:30 3530. Hippocampal Functional Networking in Wakefulness and Sleep
Kátia Cristine Andrade 1 , Victor I. Spoormaker 1 , Martin Dresler 1 , Roberto Goya-
Maldonado 1 , Renate Wehrle 2 , Florian Holsboer 1 , Philipp G. Sämann 1 , Michael Czisch 1
1 Max Planck Institute of Psychiatry, Munich, Bavaria, Germany; 2 Institute of Pharmacology and Toxicology,
University of Zurich, Zurich, Switzerland
Simultaneous EEG/fMRI resting state data reveal varying hippocampal functional connectivity during wakefulness and NREM sleep.
Our data suggest a transition from DMN bound hippocampal connectivity during the waking state to neocortical networking during
sleep stage 2. These findings may signify memory consolidation processes hypothesized to occur during sleep.
15:00 3531. Improved BOLD Detection in the Working Memory Network Using a 32 Channel
Phased Array Head Coil
Sheeba Arnold 1 , Susan Whitfield-Gabrieli 2 , Steven Shannon 1 , John Gabrieli 2 , Christina
Triantafyllou 1,3
1 A.A. Martinos Imaging Center, McGovern Institute for Brain Research, MIT, Cambridge, MA, United States;
2 Department of Brain and Cognitive Sciences, MIT, Cambridge, MA, United States; 3 A.A. Martinos Center for
Biomedical Imaging, Department of Radiology, MGH, Charlestown, MA, United States
BOLD activations cannot be located precisely with fMRI at low-resolutions. Improved sensitivity of 32-channel coil with highresolution
has been reported, but is yet to be demonstrated using fMRI at 3T. We used the n-back task to evaluate if this combination
would identify the working memory (WM) network. 12- and 32-channel data at low- and high-resolutions were acquired in 18
subjects. Paired t-test revealed WM activation for high-resolution to be significantly more with 32-channel compared to 12-channel.
When both coils are used at 3T, the increased SNR offered by 32-channel coil produces the greatest benefit for experiments in the
high-resolution regime.
Thursday 13:30-15:30 Computer 26
13:30 3532. Cross-Modal Plasticity for Auditory Processing Is Present in Normal-Hearing
Children for Non-Speech Stimuli
Vincent Jerome Schmithorst 1 , Scott Kerry Holland 1 , Elena Plante 2
1 Radiology, Children's Hospital Medical Center, Cincinnati, OH, United States; 2 Speech, Language, & Hearing
Sciences, University of Arizona, Tucson, AZ, United States
An fMRI investigation of cross-modal plasticity (the recruitment of visual areas for auditory processing tasks) was conducted in
normal-hearing children ages 7-11. Activation patterns from a narrow-band noise task were correlated with two audiological
measures of performance on comprehension of degraded speech: speech-in-noise, and time-compressed sentences at 40%
comprehension. For both audiologic tests, the visual cortex displayed a negative correlation with test performance, with positive
activation present in the worst-performing children. Results indicate that cross-modal plasticity is present even in normal-hearing
children and even for non-speech stimuli and that it negatively correlates with comprehension of degraded speech.
14:00 3533. The Rostral Supplementary Motor Area Supports the Repetition of Visually and
Auditorily Presented Pseudowords
Gesa Hartwigsen 1 , Stephan Ulmer 2 , Annette Baumgaertner 1 , Hartwig Roman Siebner 1,3
1 Department of Neurology, Christian-Albrechts-University Kiel, Kiel, Germany; 2 Institute of Neuroradiology,
University Hospital of Schleswig-Holstein, Kiel, Germany; 3 Danish Research Centre for Magnetic Resonance,
Hvidovre University Hospital, Copenhagen, Denmark
We used functional magnetic resonance imaging to delineate areas involved in modality-independent pseudoword repetition in healthy
right-handed subjects. A conjunction analysis revealed that the rostral supplementary motor area (rSMA) was activated during
pseudoword repetition. Activity in the right rSMA showed increased task-related coupling with activity in the ipsilateral primary
motor cortex (M1) and contralateral ventral premotor cortex (PMv) as revealed by a psychophysiological interaction. We show that
rSMA is involved in modality-independent pseudoword repetition. The increased task-related influence of rSMA on M1 and PMv
during pseudoword repetition suggests a supervisory role of the rSMA on executive motor areas in language production.