Safety evaluation of certain food additives - ipcs inchem

122 PHYTOSTEROLS, PHYTOSTANOLS AND THEIR ESTERS
campestanol and 0.0441 ± 0.0041% for -sitostanol (Ostlund et al., 2002). The
Committee noted that the method of determination (differential determination of
substance not excreted with faeces versus determination of oral to intravenous
tracer ratios) and the form of administration may partly explain the differences in the
bioavailability compared with older studies reviewed by the Scientific Committee on
Food (2002).
Intestinal absorption of phytosterols is drastically increased in a rare autosomal
recessive disease called sitosterolaemia (or phytosterolaemia). Patients
have 50- to 100-fold elevated plasma levels of phytosterols, comprising more than
10% of circulating sterols, compared with