Safety evaluation of certain food additives - ipcs inchem

FURAN-SUBSTITUTED ALIPHATIC HYDROCARBONS 513
Table 4. Studies of genotoxicity with furan-substituted aliphatic hydrocarbons, alcohols, aldehydes, ketones, carboxylic acids
and related esters, sulfides, disulfides and ethers used as flavouring agents
No. Flavouring agent End-point Test system Concentration/ dose Results References
In vitro
Negative b Shinohara et al. (1986)
0.165, 0.330, 0.495 or
0.660 μmol/plate (13.5,
27.1, 40.6 or 54.2 μg/platea )
1487 2-Methylfuran Reverse mutation Salmonella typhimurium
TA98 and TA100
Zeiger et al. (1992)
Up to 10 000 μg/plate Negativeb,c, d
1487 2-Methylfuran Reverse mutation S. typhimurium TA98,
TA100, TA102 and
TA1535
Zeiger et al. (1992)
Up to 10 000 μg/plate Equivocalb, c,d
1487 2-Methylfuran Reverse mutation S. typhimurium TA97 and
TA104
Negativeb Aeschbacher et al.
(1989)
11 nmol/plate to 1.1 mmol/
plate (0.9–90 310 μg/plate) a
1487 2-Methylfuran Reverse mutation S. typhimurium TA98,
TA100 and TA102
Shinohara et al. (1986)
0.16, 16 or 1600 μg/disc Negative/
positiveb,e 1487 2-Methylfuran DNA damage Bacillus subtilis H17 (rec+)
and M45 (rec)
Positive b,f Stich et al. (1981)
1487 2-Methylfuran Chromosomal aberration CHO cells 0–150 mmol/l
(0–12 315 μg/ml) a
Negative b Shinohara et al. (1986)
0.165, 0.330, 0.495 or
0.660 μmol/plate (13.5,
27.1, 40.6 or 54.2 μg/plate) g
1488 2,5-Dimethylfuran Reverse mutation S. typhimurium TA98 and
TA100