Safety evaluation of certain food additives - ipcs inchem

MISCELLANEOUS NITROGEN-CONTAINING SUBSTANCES (addendum) 553
Table 1 (contd)
Conclusion based
on current
estimated intake
Comments
on predicted
metabolism
Step B4
Adequate margin of safety for
the flavouring agent or related substance?
No. CAS No. and structure Step B3d Does intake exceed
the threshold for
human intake?
Flavouring
agent
See note 1 No safety concern
Yes. The NOELe of 12 mg/kg bw per day
for the related substance allyl
isothiocyanate (No. 1560) (National
Toxicology Program, 1982) is 60 000 times
the estimated daily intake of 2-butyl
isothiocyanate when used as a flavouring
agent.
No
Europe: ND
USA: ND
Japan: 12
1890 4426-79-3
2-Butylisothiocyanate
N C S
See note 1 No safety concern
Yes. The NOEL of 30 mg/kg bw per day for
the related substance 3-(methylthio)propyl
isothiocyanate (No. 1564) (Harper et al.,
1961) is 15 million times the estimated daily
intake of 4-(methylthio)butyl isothiocyanate
when used as a flavouring agent.
No
Europe: ND
USA: ND
Japan: 0.1
1892 4430-36-8
S
N C S
4-
(Methylthio)butyl
isothiocyanate
See note 1 No safety concern
Yes. The NOELe of 12 mg/kg bw per day
for the related substance allyl
isothiocyanate (No. 1560) (National
Toxicology Program, 1982) is >5400 times
the estimated daily intake of 4-pentenyl
isothiocyanate when used as a flavouring
agent.
No
Europe: ND
USA: ND
Japan: 132
1893 18060-79-2
4-Pentenyl
isothiocyanate
N C S